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Application of data mining technology to diagnostic imaging support of dementia using FDG-PET.

Research Project

Project/Area Number 23591818
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

ISHIZU Koichi  京都大学, 医学(系)研究科(研究院), 准教授 (50314224)

Co-Investigator(Kenkyū-buntansha) 杉本 直三  京都大学 (20196752)
山田 亮  京都大学 (50301106)
池田 昭夫  京都大学 (90212761)
中本 裕士  京都大学 (20360844)
大石 直也  京都大学 (40526878)
Co-Investigator(Renkei-kenkyūsha) 酒井 晃二  京都大学 (20379027)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsFDG-PET / 早期認知症 / 多変量解析 / データマイニング / 診断支援 / 予測分析 / SVM / k-index法 / 認知症 / 画像診断支援 / クラス判別 / alzheimer / MCI / multivariate analysis / classifier / decision making / k-index method
Research Abstract

The purpose of the present work was preliminary construction of diagnosis support system of dementia using FDG-PET image. FDG-PET images of Japanese 23 healthy volunteers and 58 MCI patients were used. 116 ROIs were automatically placed on each FDG image and region to whole brain uptake ratio was used for 2-class clasification. Support Vector Machine and k-index method, the reserch leader original, were used for the classification and area under the curve of ROC analysis was 71.1% and 74.3% respectively. It was seemed to be good results with pictures only consider the low accuracy of clinical diagnosis between MCI and normal. The inverse correlation was observed in FDG uptake in the cerebral cortex and the patient's body weight in the brain FDG-PET images of cancer a number of patients.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2013 2012 Other

All Presentation (4 results)

  • [Presentation] 腫瘍全身FDG-PETデータを用いた脳機能マッピングの試み2013

    • Author(s)
      石津浩一、東達也、大石直也、山内浩
    • Organizer
      第53回日本核医学会学術総会福岡国際会議場
    • Year and Date
      2013-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい判別アルゴリズムk-index法の紹介と医療データを用いた判別性能検証2012

    • Author(s)
      石津浩一、大石直也
    • Organizer
      第31回日本医用画像工学会大会JA北海道厚生連札幌厚生病院
    • Year and Date
      2012-08-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しいクラス判別アルゴリズムであるk-index法の紹介と核医学画像診断支援への応用2012

    • Author(s)
      石津浩一
    • Organizer
      第45回日本核医学会近畿地方会
    • Year and Date
      2012-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 腫瘍全身FDG-PETデータを用いた脳マッピングの試み

    • Author(s)
      石津浩一、大石直也
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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