| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
The purpose of this research is the development of the "nitroazole-modified glucose type radiosensitizers" which gave the radiosensitizing active group to glucose used as the substrate of a glycolytic system paying attention to the hypoxic cancer cell being dependent on a glycolytic system. As contents of the research, the design and synthesis of acetylglucose-modified 2-nitroimidazole TX-2244 and its five derivatives were done, and analysis of radiosensitizing activity and its enhancing mechanism was conducted using tumor cells and a tumor-implanted chicken egg model. It was shown clearly that TX-2244 demonstrates high radiosensitizing activity as an obtained result through the prevention of intracellular uptake of glucose, the decrease of the level of intracellular NADH(s), and increase of DNA damage by radiation.
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