Studies on photo dynamic diagnosis and photo dynamic treatment for cancer peritoneal metastases.

Research Project

Project/Area Number	23591956
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	University of Fukui
Principal Investigator	KATAYAMA Kanji 福井大学, 医学部附属病院, 教授 (30204431)
Co-Investigator(Kenkyū-buntansha)	MURAKAMI Makoto 福井大学, 医学部, 助教 (00334821) MIYOSHI Norio 福井大学, 医学部, 助教 (40209961)
Project Period (FY)	2011-04-28 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	光線力学的治療 / 腹膜転移 / ALA / PDT / LED / 脂肪乳剤 / 5-ALA / HIPEC / peritoneal metastasis
Outline of Final Research Achievements	We administered 5-ALA intaperitonally a mouse peritoneal dissemination model, and emitted fluorescence of the tumor. We emitted tumor could detect the metastatic site. We tried photo dynamics therapy also. We found cell death by radiation wavelength 630nm with cultured cell. To irradiate whole peritoneum we injected fat emulsion into peritoneum, and light reflect diffusely and performed PDT. The growth suppression of cancer cell was seen by light radiation with the fat emulsion addition culture media. Treatment effect will improve if we regulate the size of the oil droplet of the fat emulsion and transducing plural LED light source with optical fiber in a peritoneal cavity.