| Project/Area Number |
23591996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
OTSUKA Yuichiro 東邦大学, 医学部, 講師 (70287499)
KUBOTA Yoshihisa 東邦大学, 医学部, 助教 (70385699)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | SEREX / serum antibody / malignant tumor / RalA / Sui1 / ELISA / 肝細胞癌 / 血清抗体 / 腫瘍マーカー / ＳＥＲＥＸ / ＲａｌＡ / Ｓｕｉ1 / ＥＬＩＳＡ / SuiI |
|---|
| Outline of Final Research Achievements |
Purpose of this study was (i) establish ELISA system to detect serum anti-c-SEREX antibodies, RalA, Sui1, p62 and (ii) evaluate positive rate of serum anti-SEREX antibodies in patients with hepatocellular carcinoma. Using a cut-off value of mean +3SD of serum anti-SEREX antibody level of healthy controls, positive rate of patients were evaluated. The positive rates were 17% for RalA, 6% for Sui1 and 9% for p62. No clinicopathological factors were associated with presence of anti-SEREX antibodies. Immunoreactivities of resected tissues were not associated with presence of autoantibodies.
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