Peptide-cocktail vaccination for hepatocellular carcinoma
| Project/Area Number |
23592000
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUNO Kiyotaka 近畿大学, 医学部, 教授 (30169239)
TAKEYAMA Yoshifumi 近畿大学, 医学部, 教授 (70263374)
NAKAI Takuya 近畿大学, 医学部, 准教授 (60227725)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝癌ワクチン治療 / 免疫治療 / アメリカ / ヨーロッパ |
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| Research Abstract |
We performed the peptide-cocktail vaccination for hepatocellular carcinoma. The vaccine mixes an adjuvant with WDRPUH, FOXM1, MELK, HJURP-derived and HLA-A24-restricted epitope peptides. The vaccine was tried on five liver cancer patients till the present. One patient had reduction of the tumor. The other patient had SD. Although adverse events were skin induration and gastrointestinal bleeding, both were two or less grades.
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Report
(4 results)
Research Products
(1 results)
