Ischemia/Reperfusion-induced Myocardial Damage: Role of Carbon Dioxide
| Project/Area Number |
23592023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Akita University |
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Principal Investigator |
YAMAMOTO Hiroshi 秋田大学, 医学(系)研究科(研究院), 准教授 (10270795)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Fumio 秋田大学, 大学院医学系研究科, 教授 (00127474)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 心筋虚血再灌流 / 二酸化炭素 / ナトリウム/水素交換 / ナトリウム/カルシウム交換 / 心筋保護 / 開心術 / 心筋虚血 / 虚血再灌流 / 塩素イオン / 重炭酸イオン / 心筋虚血再灌流傷害 / 好気的代謝 / 二酸化炭素産生 / イオン移動 / CO2産生 |
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| Research Abstract |
We investigated the acid-base characteristic alterations of blood cardioplegia (BCP) during aortic cross-clamping in hearts arrested with BCP and during in vitro simulated ischemia. In 40 patients undergoing cardiac surgery following an aortic cross clamp, hearts were infused with a hypothermic BCP intermittently and lastly with a normothermic BCP prior to aortic cross clamp release. We measured pH, pCO2, [HCO3-], and [Cl-] of the coronary sinus effluent in the final BCP. BCP was assessed under in-vitro gassing at with 95% N2 + 5% CO2 (n = 6), 50% N2 + 50% CO2 (n = 3), or 100% CO2 (n = 6). The coronary sinus effluent, compared with the pre-infused BCP, exhibited significantly lower pH and greater pCO2 with no change in the [HCO3-] level. In vitro, the 100% CO2 gassing groups exhibited a significant increase in [HCO3-] under high pCO2-induced acidification. Under anoxia and CO2 retention during aortic cross-clamping, BCP can be a bicarbonate donor to the myocardium.
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Report
(4 results)
Research Products
(11 results)
