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Animal implant research on small suturing device which eliminates knot tying

Research Project

Project/Area Number 23592029
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

ONO Minoru  東京大学, 医学部附属病院, 教授 (40270871)

Co-Investigator(Kenkyū-buntansha) SAKUMA Ichiro  東京大学, 大学院工学系研究科, 教授 (50178597)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords低侵襲手術 / 冠状動脈バイパス術 / 内視鏡手術 / ロボット手術 / 血管吻合 / 吻合デバイス
Research Abstract

We developed a new suturing device which enables to perform coronary artery bypass surgery under endoscopic and/or robotic assistance. First, we confirmed sufficient stretch-resistant forces and acceptable biological safety of this device. Then, we created chronic models of rabbit carotid artery bypass using jugular vein and swine off-pump coronary artery bypass using bilateral internal thoracic arteries, comparing regular suture and this new device. Graft patency and grade of inflammatory cell infiltration were similar between two groups. Thereby, it was shown that this new suturing device is safe and effective. Evaluation of efficacy of this suturing device in endoscopic and/or robotic condition is warranted.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (18 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Development of a suturing device for anastomosis for small caliber arteries.2014

    • Author(s)
      Itoda Y, Panthee N, Tanaka T, Ando T, Sakuma I, Ono M
    • Journal Title

      Journal of Artificial Organs

      Volume: 17 Issue: 1 Pages: 88-94

    • DOI

      10.1007/s10047-013-0749-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] インテリジェント手術支援ロボット-その要素技術と周辺機器の開発-2014

    • Author(s)
      小野稔、小林英津子、安藤岳洋、許俊鋭、佐久間一郎
    • Journal Title

      医工学治療

      Volume: 26 Pages: 40-46

    • Related Report
      2013 Final Research Report
  • [Journal Article] インテリジェント手術支援ロボット-その要素技術と周辺機器の開発-2014

    • Author(s)
      小野 稔、小林英津子、安藤岳洋、許 俊鋭、佐久間一郎
    • Journal Title

      医工学治療

      Volume: 26 Pages: 40-46

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of a new device for distal coronary anastomosis–pig model -2013

    • Author(s)
      Itoda Y, Panthee N, Tanaka T, Ando T, Sakuma I, Ono M.
    • Journal Title

      Proceedings of IEEE-EMBC

      Volume: 3166

    • Related Report
      2013 Final Research Report
  • [Journal Article] 新しい冠動脈吻合用デバイスの研究~ブタ冠動脈バイパス手術での前臨床試験~2013

    • Author(s)
      井戸田佳史、Nirmal Panthee、安藤岳洋、佐久間一郎、小野稔
    • Journal Title

      日本コンピュータ外科学会雑誌

      Volume: 15 Pages: 160-161

    • NAID

      10031194153

    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい冠動脈末梢側吻合デバイスの研究-慢性期動物モデルでの報告-2014

    • Author(s)
      井戸田佳史、Panthee Nirmal、安藤岳洋、佐久間一郎、小野稔
    • Organizer
      第44回日本心臓血管外科学会学術総会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] A new suture for distal coronary artery anastomosis which eliminates knot-tying2014

    • Author(s)
      Minoru Ono, Yoshifumi Itoda, Nirmal Panthee, Takehiro Ando, and Ichiro Sakuma
    • Organizer
      2014 Annual Meeting of International Society for Minimally Invasive Cardiothoracic Surgery
    • Place of Presentation
      米国、ボストン
    • Related Report
      2013 Annual Research Report
  • [Presentation] A new suture device for distal coronary artery bypass surgery2013

    • Author(s)
      Ono M, Itoda Y, Panthee N, Ando T, Sakuma I.
    • Organizer
      2013 Annual Meeting of International Society for Minimally Invasive Cardiothoracic Surgery
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい冠動脈吻合用デバイスの研究-ブタ冠動脈バイパス手術での前臨床試験-2013

    • Author(s)
      井戸田佳史、Panthee Nirmal、安藤岳洋、佐久間一郎、小野稔
    • Organizer
      第22回日本コンピュータ外科学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Use of A New Suture Device For Distal Coronary Anastomosis -Swine Coronary Artery Bypass Model2013

    • Author(s)
      Itoda Y, Panthee N, Ando T, Sakuma I, Ono M.
    • Organizer
      Joint International Congress of 51^<st> Annual Meeting of Japanese Society of Artificial Organs and 5^<th> Congress of International Federation for Artificial Organs
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい冠動脈末梢側吻合デバイスの研究-ブタ冠動脈を用いた実験モデルでの報告2013

    • Author(s)
      井戸田佳史、Nirmal Panthee、安藤岳洋、佐久間一郎、小野稔
    • Organizer
      第66回日本胸部外科学会定期学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 内視鏡手術で利用可能な新しい冠動脈末梢吻合用デバイスの研究2013

    • Author(s)
      井戸田佳史、Panthee Nirmal、安藤岳洋、佐久間一郎、小野稔
    • Organizer
      第26回日本内視鏡外科学会総会パネルディスカッション
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] USE OF NEW DEVICE FOR DISTAL CORONARY ANASTOMOSIS-RABBIT CAROTID ARTERY MODEL2013

    • Author(s)
      Itoda Y, Panthee N, Ando T, Sakuma I, Ono M
    • Organizer
      21st Annual Meeting of the Asian Society for Thoracic and Cardiovascular Surgery
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低侵襲インテリジェント手術支援用ロボット技術の開発2013

    • Author(s)
      小野 稔、佐久間一郎、小林英津子、安藤岳洋、中島 淳、許 俊鋭
    • Organizer
      日本医工学治療学会第29回学術大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Invited
  • [Presentation] A new suture device for distal coronary artery bypass surgery2013

    • Author(s)
      Ono M, Itoda Y, Panthee N, Ando T, Sakuma I
    • Organizer
      2013 Annual Meeting of International Society for Minimally Invasive Cardiothoracic Surgery
    • Place of Presentation
      チェコ共和国、プラハ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新しい冠動脈抹消側吻合デバイスの研究-ブタ冠動脈を用いた実験モデルでの報告2013

    • Author(s)
      井戸田佳史、Nirmal Panthee、安藤岳洋、佐久間一郎、小野 稔
    • Organizer
      日本胸部外科学会定期学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] Use of A New Suture Device For Distal Coronary Anastomosis -Swine Coronary Artery Bypass Model-2013

    • Author(s)
      Yoshifumi Itoda, Nirmal Panthee, Takehiro Ando, Ichiro Sakuma, Minoru Ono
    • Organizer
      Japanese Society for Artificial Organs/International Federation for Artificial Organs Joint Congress 2013
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 内視鏡手術で利用可能な新しい冠動脈末梢吻合用デバイスの研究2013

    • Author(s)
      井戸田佳史、Panthee Nirmal、安藤岳洋、佐久間一郎、小野 稔
    • Organizer
      第26回日本内視鏡外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Use of a new device for distal coronary anastomosis2013

    • Author(s)
      Itoda Y, Panthee N, Ando T, Sakuma I, and Ono M
    • Organizer
      21st Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] 低侵襲手術支援用ロボット技術の開発2012

    • Author(s)
      佐久間一郎、小林英津子、安藤岳洋、鄭 常賢、小野 稔、許 俊鋭、中島 淳
    • Organizer
      第25回日本内視鏡外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 新しい冠動脈半自動吻合デバイスの研究-ウサギ頸動脈モデルにおける中間報告-2012

    • Author(s)
      井戸田佳史、Panthee Nirmal、安藤岳洋、佐久間一郎、小野 稔
    • Organizer
      第50回日本人工臓器学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 新しい冠動脈半自動吻合デバイスの研究2012

    • Author(s)
      小野 稔、井戸田佳史、Nirmal Panthee、安藤岳洋、佐久間一郎
    • Organizer
      第21回コンピュータ外科学会大会
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report
  • [Presentation] Use of a new device for distal coronary anastomosis–pig model–

    • Author(s)
      Itoda Y, Panthee N, Ando T, Sakuma I, Ono M.
    • Organizer
      35^<th> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 結紮を不要とする縫合糸デバイスの留め具の新しい形状2014

    • Inventor(s)
      小野 稔
    • Industrial Property Rights Holder
      小野 稔
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-03-20
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 組織結紮デバイス2013

    • Inventor(s)
      小野 稔
    • Industrial Property Rights Holder
      小野 稔
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-28
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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