Bone Marrow Mononuclear Cell transplantation as a therapeutic option for pulmonary arterial hypertension and its role of BM-MNCs
| Project/Area Number |
23592040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Tetsuya 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80240886)
SUGANO Mikio 徳島大学, 大学病院, 医員 (70563807)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肺高血圧 / 骨髄単核球移植 / マウスモデル |
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| Research Abstract |
We investigated the effects and possible mechanism of bone marrow mononuclear cell (BM-MNC) transplantation on pulmonary arterial hypertension induced by monocrotaline. The monocrotaline-injected mice improved significantly 4 weeks after BM-MNC transplantation compared with mice at 8 weeks after monocrotaline injection. BM-MNCs were incorporated into the lung at 30 minutes after transplantation, and significant vascular endothelial growth factor (VEGF) upregulation and almost no change of its receptor expression were observed in the lung tissue 1 week after transplantation. Moreover the improvement of pulmonary arterial hypertension was inhibited by simultaneous administration of VEGF receptor-2 inhibitor with BMMNC transplantation.
BMMNC transplantation improves monocrotaline-induced pulmonary arterial hypertension by favorable pulmonary artery remodeling through VEGF upregulation and its receptor system.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model.2013
Author(s)
Kurobe H, Hirata Y, Matsuoka Y, Sugasawa N, Higashida M, Nakayama T, Maxfield MW, Yoshida Y, Shimabukuro M, Kitagawa T, Sata M.
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Journal Title
J Surg Res
Volume: 185
Issue: 1
Pages: 455-462
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling2013
Author(s)
Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield M, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S.
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Journal Title
Cardiovasc Res
Volume: 99
Issue: 4
Pages: 705-715
DOI
Related Report
Peer Reviewed
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[Presentation] Macrophage-Specific Hypoxia-Inducible Factor (HIF)-1α-Deficient Mice Suppress the Vascular Remodeling and Regulate M2 Macrophage Polarization2013
Author(s)
Taisuke Nakayama, Hirotsugu Kurobe, Noriko Sugasawa, Hajime Kinoshita, Yasushi Yoshida, Yoichiro Hirata, Mie Sakata, Mark Webster Maxfield, Michio Shimabukuro, Yousuke Takahama, Masataka Sata, Toshiaki Tamaki, Tetsuya Kitagawa, Shuhei Tomita
Organizer
American Heart Association AHA 2013
Place of Presentation
Dallas Convention Center(アメリカ テキサス州ダラス市)
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