Mechanism of pain generation in the rat model of brachial plexus avulsion and the effect of anti-nerve growth factor receptor (p75 neurotrophin receptor) administration
| Project/Area Number |
23592158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTORI Seiji 千葉大学, 医学研究院, 講師 (40361430)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 腕神経叢損傷 / 疼痛 / 機序 / p75NTR阻害 / microglia / astrocyte / satellite cell |
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| Research Abstract |
In the rat model of brachial plexus avulsion (BPA), pain-related behavior and the extent of glial activation was evaluated. The effect of local and general administration of anti-nerve growth factor receptor (p75 neurotrophin receptor [p75NTR]) antibodies was also evaluated in the BPA model. As a result, rats in the BPA group displayed significant mechanical hyperalgesia in the dermatome innervated by uninjured nerves both ipsilaterally and contra laterally. GFAP-immunoreactive astrocytes and Iba1-immunoreactive microglia were significantly activated on the ipsilateral side in the BPA group. And in the both rats group in which anti-p75NTR was locally or generally, mechanical hyperalgesia was significantly improved. Levels of GFAP-immunoreactive astrocytes and Iba1-immunoreactive microglia in the anti-p75NTR group were significantly reduced.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] The Effect of Anti-NGF Receptor (p75 Neurotrophin Receptor) Antibodies on Nociceptive Behavior and Activation of Spinal Microglia in the Rat Brachial Plexus Avulsion Model2013
Author(s)
3. Matsuura Y, Iwakura N, Ohtori S, Suzuki T, Kuniyoshi K, Murakami K, Hiwatari R, Hashimoto K, Okamoto S, Shibayama M, Kobayashi T, Ogawa Y, Sukegawa K, Takahashi K
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Journal Title
Related Report
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