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Development of oncolytic virotherapy using live attenuated poliovirus for human bone and soft tissue sarcomas.

Research Project

Project/Area Number 23592183
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

MATSUMINE Akihiko  三重大学, 医学(系)研究科(研究院), 准教授 (00335118)

Co-Investigator(Kenkyū-buntansha) ASANUMA Kunihiro  三重大学, 大学院医学系研究科, 助教 (20378285)
MATSUBARA Takao  三重大学, 医学系研究科, 講師 (30422827)
NAKAMURA Tomoki  三重大学, 医学部附属病院, 助教 (50467362)
TOYODA Hidemi  三重大学, 大学院医学系研究科, 助教 (60525327)
KOMADA Yoshihiro  三重大学, 大学院医学系研究科, 教授 (80186791)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords弱毒化ポリオウイルス / 悪性骨軟部腫瘍 / 細胞融解療法 / CD155 / ポリオウイルス / ポリオ生ワクチン / 肉腫 / 細胞死 / アポトーシス / ポリオウイルスレセプター
Research Abstract

The poliovirus receptor CD155, is essential for poliovirus to induce cell-death in neural cells. Recently, CD155 has been shown to be selectively expressed on certain types of tumor cells originating from the neural crest. We first examined CD155 expression in sarcoma cell lines, and found the expression of CD155 in all of 10 sarcoma cell lines. Furthermore, we found that live-attenuated polio viruses (LAPV) induced apoptosis. In nude mice transplanted with HT1080, administration of live attenuated poliovirus caused growth suppression of the tumors. Next, the CD155 expression levels in 43 surgically resected soft tissue tumors were evaluated. The local recurrence free survival rate for patients with a high CD155 expression level was significantly poorer compared with that of patients with low CD155 expression levels.
These results suggest that oncolytic therapy using a LAPV may represent a new option for the treatment of sarcomas.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (147 results)

All 2014 2013 2012 2011

All Journal Article (50 results) (of which Peer Reviewed: 50 results) Presentation (92 results) Book (5 results)

  • [Journal Article] Role of High-sensitivity C-reactive Protein in the Differentiation of Benign and Malignant Soft Tissue Tumors2014

    • Author(s)
      Nakamura T, Matsumine A, Iino T, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Journal Title

      Anticancer Res

      Volume: 34 Pages: 933-936

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Role+of+High-sensitivity+C-reactive+Protein+in+the+Differentiation+of+Benign+and+Malignant+Soft+Tissue+Tumors

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation for the treatment of recurrent bone and soft-tissue sarcomas in non-surgical candidates.2014

    • Author(s)
      Yamakado K, Matsumine A, Nakamura T, Nakatsuka A, Takaki H, Matsubara T, Asanuma K, Sudo A, Sugimura Y, Sakuma H.
    • Journal Title

      Int J Clin Oncol

      Volume: 印刷中 Issue: 5 Pages: 955-962

    • DOI

      10.1007/s10147-013-0640-8

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of Kyocera Modular Limb Salvage system after resection of bone sarcoma of the distal part of the femur : the Japanese Musculoskeletal Oncology Group study2013

    • Author(s)
      Nakamura T, Matsumine A, Uchida A, Kawai A, Nishida Y, Kunisada T, Araki N, Sugiura H, Tomita M, Yokouchi M, Ueda T, Sudo A
    • Journal Title

      Int Orthop

      Volume: 38 Issue: 4 Pages: 825-830

    • DOI

      10.1007/s00264-013-2151-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma.2013

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A.
    • Journal Title

      J Surg Oncol

      Volume: 108(7) Issue: 7 Pages: 481-485

    • DOI

      10.1002/jso.23424

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deep-vein thrombosis after resection of musculoskeletal tumours of the lower limb.2013

    • Author(s)
      Yamaguchi T, Matsumine A, Niimi R, Nakamura T, Matsubara T, Asanuma K,Hasegawa M, Sudo A.
    • Journal Title

      Bone Joint J

      Volume: 95(9) Issue: 9 Pages: 1280-1284

    • DOI

      10.1302/0301-620x.95b9.30905

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ewing's sarcoma with an uncommon clinical course : A case report2013

    • Author(s)
      Niimi R, Matsumine A, Nakamura T, Morimoto R, Murata T, Suzuki T, Nakashima Y, Nojima T, Uchida A, Sudo A
    • Journal Title

      Oncol Lett

      Volume: 6 Issue: 1 Pages: 9-12

    • DOI

      10.3892/ol.2013.1320

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CD155 mRNA expression in soft tissue sarcomas2013

    • Author(s)
      Atsumi S, Matsumine A, Toyoda H, Niimi R, Iino T, Sudo A
    • Journal Title

      Oncol Lett

      Volume: 5(6) Issue: 6 Pages: 1771-1776

    • DOI

      10.3892/ol.2013.1280

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors2013

    • Author(s)
      Niimi R, Matsumine A, Iino T, Nakazora S, Nakamura T, Uchida A, Sudo A
    • Journal Title

      BMC Cancer

      Volume: 26 Issue: 1

    • DOI

      10.1186/1471-2407-13-309

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of radiofrequency ablation and metastasectomy in elderly patients with lung metastases from musculoskeletal sarcomas2013

    • Author(s)
      Nakamura T, Matsumine A, Yamakado K, Takao M, Uchida A, Sudo A
    • Journal Title

      J Cancer Res Ther

      Volume: 9(2)(PMID:23771362, PubMed - indexed for MEDLINE) Issue: 2 Pages: 219-23

    • DOI

      10.4103/0973-1482.113358

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Can a less radical surgery using photodynamic therapy with acridine orange be equal to a wide-margin resection?2013

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Nakamura T, Sudo A.
    • Journal Title

      Clin Orthop Relat Res

      Volume: 471(3) Issue: 3 Pages: 792-802

    • DOI

      10.1007/s11999-012-2616-9

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone.2013

    • Author(s)
      Asanuma K, Wakabayashi H, Okamoto T, Asanuma Y, Akita N, Yoshikawa T, Hayashi T, Matsumine A, Uchida A, Sudo A.
    • Journal Title

      Breast Cancer

      Volume: 20(3) Issue: 3 Pages: 241-246

    • DOI

      10.1007/s12282-012-0334-5

    • NAID

      10031202704

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ewing's sarcoma with an uncommon clinical course: A case report.2013

    • Author(s)
      Niimi R, Matsumine A, Nakamura T, Morimoto R, Murata T, Suzuki T, Nakashima Y,
    • Journal Title

      Oncol Let

      Volume: 6(1) Pages: 9-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors.2013

    • Author(s)
      Niimi R, Matsumine A, Iino T, Nakazora S, Nakamura T, Uchida A, Sudo A.
    • Journal Title

      BMC Cancer

      Volume: 26;13(1) Pages: 309-309

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CD155 mRNA expression in soft tissue sarcomas.2013

    • Author(s)
      Atsumi S, Matsumine A, Toyoda H, Niimi R, Iino T, Sudo A.
    • Journal Title

      Oncol Lett

      Volume: 5(6) Pages: 1771-1776

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel p53 splicing site mutation in Li-Fraumeni-like syndrome with osteosarcoma.2013

    • Author(s)
      Sakurai N, Iwamoto S, Miura Y, Nakamura T, Matsumine A, Nishioka J, Nakatani K, Komada Y.
    • Journal Title

      Pediatr Int

      Volume: 55(1) Issue: 1 Pages: 107-111

    • DOI

      10.1111/j.1442-200x.2012.03641.x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: a phase II trial in Japan.2013

    • Author(s)
      Kudawara I
    • Journal Title

      J Chemother.

      Volume: 25 Issue: 1 Pages: 41-8

    • DOI

      10.1179/1973947812y.0000000055

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨軟部腫瘍手術でFondaparinuxを使用した13例の検討2013

    • Author(s)
      淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、長谷川正裕、須藤啓広
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 56(2) Pages: 497-498

    • NAID

      10031174953

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 橈骨遠位骨巨細胞腫による骨変形で生じた長母指伸筋腱断裂の1例2013

    • Author(s)
      塚本 正、辻井雅也、植村 剛、松峯昭彦、須藤啓広、森本政司
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 56(3) Pages: 601-602

    • NAID

      10031188808

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コンパートメント症候群様症状で発症した悪性リンパ腫の1例2013

    • Author(s)
      伊東直也、松峯昭彦、竹上徳彦、辻井雅也、須藤啓広
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 56(5) Pages: 1159-1160

    • NAID

      130004144044

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【転移性肺腫瘍の外科治療】 骨・軟部悪性腫瘍肺転移例に対する治療2013

    • Author(s)
      天白宏典、高尾仁二、島本 亮、村嶋秀市、山門亨一郎、中村知樹、松峯昭彦、新保秀人
    • Journal Title

      胸部外科

      Volume: 66(4) Pages: 311-314

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of pretreatment serum C-reactive protein level in soft tissue sarcoma2012

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Journal Title

      Cancer

      Volume: 118(4) Issue: 4 Pages: 1055-61

    • DOI

      10.1002/cncr.26353

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity2012

    • Author(s)
      Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y.
    • Journal Title

      Curr Pharm Des

      Volume: 18 Issue: 10 Pages: 1414-1420

    • DOI

      10.2174/138161212799504812

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prosthetic limb salvage surgery for bone and soft tissue tumors around the knee.2012

    • Author(s)
      Niimi R, Matsumine A, Hamaguchi T, Nakamura T, Uchida A, Sudo A.
    • Journal Title

      Oncol Rep.

      Volume: 28(6) Issue: 6 Pages: 1984-90

    • DOI

      10.3892/or.2012.2021

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus.2012

    • Author(s)
      Atsumi S, Matsumine A, Toyoda H, Niimi R, Iino T, Nakamura T, Matsubara T, Asanuma K, Komada Y, Uchida A, Sudo A.
    • Journal Title

      Int J Oncol.

      Volume: 41(3) Issue: 3 Pages: 893-902

    • DOI

      10.3892/ijo.2012.1514

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel hyperthermia treatment for bone metastases using magnetic materials2011

    • Author(s)
      Matsumine A, Takegami K, Asanuma K, Matsubara T, Nakamura T, Uchida A, Sudo A
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Issue: 2 Pages: 101-108

    • DOI

      10.1007/s10147-011-0217-3

    • NAID

      10029366305

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of the KYOCERA Physio Hinge Total Knee System Type III after the resection of a bone and soft tissue tumor of the distal part of the femur2011

    • Author(s)
      Matsumine A, Ueda T, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Hiraga H, Sudo A, Uchida A
    • Journal Title

      J Surg Oncol

      Volume: 103 Issue: 3 Pages: 257

    • DOI

      10.1002/jso.21823

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The adverse effect of an unplanned surgical excision of foot soft tissue sarcoma2011

    • Author(s)
      Nishimura A, Matsumine A, Asanuma K, Matsubara T, Nakamura T, Uchida A, Kato K, Sudo A
    • Journal Title

      World J Surg Oncol

      Volume: 9 Issue: 1 Pages: 160-160

    • DOI

      10.1186/1477-7819-9-160

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transfection of NF- κ B decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma2011

    • Author(s)
      Nishimura A, Akeda K, Matsubara T, Kusuzaki K, Matsumine A, Masuda K, Gemba T, Uchida A, Sudo A
    • Journal Title

      Cancer Gene Ther

      Volume: 18(4) Issue: 4 Pages: 250-259

    • DOI

      10.1038/cgt.2010.75

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent ankle equinus deformity due to intramuscular hemangioma of the gastrocnemius : case report2011

    • Author(s)
      Nakamura T, Matsumine A, Nishiyama M, Uchida A, Sudo A
    • Journal Title

      Foot Ankle Int

      Volume: 32 Pages: 905-907

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Recurrent+ankle+equinus+deformity+due+to+intramuscular+hemangioma+of+the+gastrocnemius%3A+case+report

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of the tumor volume doubling time on sarcoma patients with lung metastases2011

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Journal Title

      Clin Exp Metastasis

      Volume: 28 Issue: 8 Pages: 819-825

    • DOI

      10.1007/s10585-011-9413-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The symptom-to-diagnosis delay in soft tissue sarcoma influence the overall survival and the development of distant metastasis2011

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Journal Title

      J Surg Oncol

      Volume: 104(7) Issue: 7 Pages: 771-5

    • DOI

      10.1002/jso.22006

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extraslkeletal subcutaneous osateosarcoma of the upper arm : A case report2011

    • Author(s)
      Nakamura T, Matsumine A, Nishimura K, Yokoyama H, Murata T, Uchida A, Sudo A
    • Journal Title

      Oncology Letters

      Volume: 2 Issue: 1 Pages: 75-77

    • DOI

      10.3892/ol.2010.204

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective analysis of metastatic sarcoma patients2011

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Niimi R, Uchida A, Sudo A
    • Journal Title

      Oncology Letters

      Volume: 2 Issue: 2 Pages: 315-318

    • DOI

      10.3892/ol.2011.238

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011

    • Author(s)
      Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 4163-4168

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Acridine+orange+inhibits+pulmonary+metastasis+of+mouse+osteosarcoma

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNF inhibitor suppresses bone metastasis in a breast cancer cell line2011

    • Author(s)
      Hamaguchi T, Wakabayashi H, Matsumine A, Sudo A, Uchida A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407 Issue: 3 Pages: 525-530

    • DOI

      10.1016/j.bbrc.2011.03.051

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma.2011

    • Author(s)
      Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A.
    • Journal Title

      Anticancer Res.

      Volume: 31(12) Pages: 4163-8

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The adverse effect of an unplanned surgical excision of foot soft tissue sarcoma.2011

    • Author(s)
      Nishimura A, Matsumine A, Asanuma K, Matsubara T, Nakamura T, Uchida A, Kato K, Sudo A.
    • Journal Title

      World J Surg Oncol.

      Volume: 9 Pages: 160-160

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrent ankle equinus deformity due to intramuscular hemangioma of the gastrocnemius: case report.2011

    • Author(s)
      Nakamura T, Matsumine A, Nishiyama M, Uchida A, Sudo A.
    • Journal Title

      Foot Ankle Int.

      Volume: 32(9) Pages: 905-7

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of the tumor volume doubling time on sarcoma patients with lung metastases.2011

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A.
    • Journal Title

      Clin Exp Metastasis.

      Volume: 28(8) Pages: 819-25

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] TNF inhibitor suppresses bone metastasis in a breast cancer cell line.2011

    • Author(s)
      Hamaguchi T, Wakabayashi H, Matsumine A, Sudo A, Uchida A.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 407(3) Pages: 525-30

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel hyperthermia treatment for bone metastases using magnetic materials.2011

    • Author(s)
      Matsumine A, Takegami K, Asanuma K, Matsubara T, Nakamura T, Uchida A, Sudo A.
    • Journal Title

      Int J Clin Oncol.

      Volume: 16(2) Pages: 101-8

    • NAID

      10029366305

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 環椎溶骨性変化に斜頸を合併したspinal osseous epidural AVFの1例.2011

    • Author(s)
      奥野一真, 松原孝夫, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広.
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 147-148

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 当院における高齢者骨肉腫の予後規定因子の検討.2011

    • Author(s)
      淺沼邦洋, 松峯昭彦, 松原孝夫, 中村知樹, 内田淳正, 須藤啓広
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 81-82

    • NAID

      10029071256

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 下肢骨軟部腫瘍術後の深部静脈血栓症の発生率.2011

    • Author(s)
      山口敏郎, 松峯昭彦, 長谷川正裕, 中村知樹, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 79-80

    • NAID

      10029071248

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨肉腫・ユーイング肉腫に対するアクリジンオレンジ光線および放射線力学的療法の治療成績.2011

    • Author(s)
      松原孝夫, 楠崎克之, 中村知樹, 松峯昭彦, 内田淳正, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 73-74

    • NAID

      10029071238

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肺転移に対しGemcitabineが有効であった骨肉腫の1例.2011

    • Author(s)
      松原孝夫, 楠崎克之, 中村知樹, 松峯昭彦, 内田淳正, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 59-60

    • NAID

      10029071197

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 軟部肉腫における不適切切除後の広範切除症例に対するMRIの有効性2011

    • Author(s)
      中村知樹, 松峯昭彦, 松原孝夫, 浅沼邦洋, 須藤啓広 .
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(1) Pages: 39-40

    • NAID

      10029071134

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨外性粘液型軟骨肉腫の治療成績.2011

    • Author(s)
      中村知樹, 松峯昭彦, 松原孝夫, 淺沼邦洋, 楠崎克之, 須藤啓広
    • Journal Title

      整形外科

      Volume: 62(6) Pages: 513-516

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 軟部腫瘍と鑑別を要した痛風結節の4例.2011

    • Author(s)
      奥野一真, 中村知樹, 松原孝夫, 浅沼邦洋, 松峯昭彦, 須藤啓広.
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(4) Pages: 761-762

    • NAID

      10029661651

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性骨軟部腫瘍における腫瘍細胞外pHと予後の検討.2011

    • Author(s)
      松原孝夫, 楠崎克之, 中村知樹, 浅沼邦洋, 松峯昭彦, 須藤啓広.
    • Journal Title

      中部日本整形外科災害外科学会雑誌

      Volume: 54(4) Pages: 745-746

    • NAID

      10029661608

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Acridine Orange Therapy as a New Less-invasive Surgery for Recurrent or Aggressive Giant Cell Tumor of Bone2014

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Asanuma K, Nakamura T, Sudo A
    • Organizer
      American Academy of Orthopaedic Surgeons
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Soluble N-cadherin as a Biomarker for Malignant Bone and Soft Tissue Tumors2014

    • Author(s)
      Matsumine A, Niimi R, Iino T, Nakamura T, Matsubara T, Asanuma K, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Soluble cd155 As A Biomarker For Malignant Bone And Soft Tissue Tumors2014

    • Author(s)
      Goto M, Matsumine A, Nakamura T, Matsubara T, Asanuma K, Oi T, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Carbonic Anhydrase iX has the Potential to Predict Preoperative chemotherapy effect2014

    • Author(s)
      Okuno K, Matsubara T, Matsumine A, Asanuma K, Nakamura T, Goto M, Oi T, Sudo A
    • Organizer
      On human Osteosarcoma Patients. Orthopaedic Research Society
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Cucurbitacin i (jsi-124) induces Apoptosis in human Osteosarcoma cells2014

    • Author(s)
      Oi T, Asanuma K, Nakamura T, Matsubara T, Matsumine A, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor Microenvironmental Factors and Acridine Orange intensity can Predict clinical Outcome in Soft Tissue Sarcoma Patients2014

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Asanuma K, Nakamura T, Okuno K, Goto M, Oi T, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The expression of Tissue Factor mRNA in bone and soft tissue sarcoma patients2013

    • Author(s)
      Asanuma K, Matsumine A, Matsubara T, Nakamura T, Ooi T, Asanuma Y, Sudo A
    • Organizer
      European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical outcomes in the oldest old patients (85 years or old) with musuculoskeletal sarcomas2013

    • Author(s)
      Ooi T, Matsumine A, Goto M, Nakamura T, Matsubara T, Asanuma K, Sudo A
    • Organizer
      European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Final Research Report
  • [Presentation] Acridine Orange Therapy as a New Less-invasive Limb Salvage Surgery for Rhabdomyosarcomas and Synovial Sarcomas2013

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Asanuma K, Nakamura T, Sudo A
    • Organizer
      American Academy of Orthopaedic Surgeons
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] C-reactive Protein Level May be a Marker of Tumor Aggressiveness in Soft Tissue Sarcoma Patients2013

    • Author(s)
      Nakamura T, Matsumine A, Matsubara T, Asanuma K, Sudo A
    • Organizer
      American Academy of Orthopaedic Surgeons
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Thrombomodulin and Tissue Factor mRNA Expression in 62 Soft Tissue Sarcoma Patients2013

    • Author(s)
      Asanuma K, Matsumine A, Matsubara T, Nakamura T, Yoshikawa T, Sudo A
    • Organizer
      American Academy of Orthopaedic Surgeons
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of Tumor Metastatic Factor Using Coagulation Activity Model in Mice2013

    • Author(s)
      Asanuma K, Matsumine A, Asanuma Y, Akita N, Yoshikawa T, Matsubara T, Nakamura T, Okamoto T, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] New hyperthermic treatment with magnetic materials for metastatic bone tumor.2013

    • Author(s)
      Matsumine A, Matsubara T, Asanuma K, Nakamura T, Takegami K, Sudo A.
    • Organizer
      26th European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Annual Research Report
  • [Presentation] The expression of Tissue Factor mRNA in bone and soft tissue sarcoma patients.2013

    • Author(s)
      Asanuma K, Matsumine A, Matsubara T, Nakamura T, Ooi T, Asanuma Y, Sudo A.
    • Organizer
      26th European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Annual Research Report
  • [Presentation] Less Radical Resection for Tissue Sarcomas Combined with Chemotherapy and Acridine Orange Photodynamic Therapy Produced Excellent Local Control.2013

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Asanuma K, Nakamura T, Uchida A, Sudo A.
    • Organizer
      26th European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical outcomes in the oldest old patients (85 years or old) with musuculoskeletal sarcomas.2013

    • Author(s)
      Ooi T, Matsumine A, Goto M, Nakamura T, Matsubara T, Asanuma K, Sudo A.
    • Organizer
      26th European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Annual Research Report
  • [Presentation] Granular cell tumors of soft tissue :A report of five cases.2013

    • Author(s)
      Goto M, Matsumine A, Asanuma K, Matsubara T, Nakamura T, Ooi T, Sudo A.
    • Organizer
      26th European Musculo-Skeletal Oncolory Society
    • Place of Presentation
      Gothenburg, Swedwn
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical outcomes of revision surgery for failed tumor prostheses.2013

    • Author(s)
      Matsumine A, Asanuma K, Matsubara T, Nakamura T, Ooi T, Goto M, Sudo A.
    • Organizer
      International Society of Limb Salvage 17th General Meeting
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical outcome of the KLS total Knee system after resection of bone sarcomas of the distal part of the femur: Japanese musculoskeletal oncology group (JMOG) study.2013

    • Author(s)
      Nakamura T, Matsumine A, Uchida A, Kawai A, Nishida Y, Kunisada T, Araki N, Sugiura H, Ueda T, Sudo A.
    • Organizer
      International Society of Limb Salvage 17th General Meeting
    • Place of Presentation
      Bologna, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨軟部肉腫に他悪性腫瘍を合併した多重癌の検討2013

    • Author(s)
      浅沼邦洋、松峯昭彦、松原孝夫、中村知樹、大井徹、須藤啓広
    • Organizer
      第120回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 化学療法感受性腫瘍に対するアクリジンオレンジ療法の検討2013

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、浅沼邦洋、中村知樹、須藤啓広
    • Organizer
      第120回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腫瘍切除後に自家処理骨を用いて再建を行った大腿骨骨幹部Ewing肉腫の治療成績2013

    • Author(s)
      中村知樹、Abudu Adesegun、松峯昭彦、松原孝夫、浅沼邦洋、須藤啓広
    • Organizer
      第120回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上腕骨近位原発性骨悪性腫瘍に対する治療成績2013

    • Author(s)
      大井 徹、中村知樹、松原孝夫、浅沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第120回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肋骨原発悪性骨腫瘍の治療成績2013

    • Author(s)
      後藤幹伸、松峯昭彦、中村知樹、松原孝夫、浅沼邦洋、須藤啓広
    • Organizer
      第120回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンパートメント症候群様症状で発症した悪性リンパ腫の1例2013

    • Author(s)
      伊東直也、松峯昭彦、竹上德彦、辻井雅也、須藤啓広
    • Organizer
      第120回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] アクリジンオレンジ治療法2013

    • Author(s)
      楠崎克之、松原孝夫、松峯昭彦、須藤啓広
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨腫瘍に対する磁性体温熱療法2013

    • Author(s)
      松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、後藤幹伸、大井 徹、須藤啓広
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高悪性軟部腫瘍に対するアクリジンオレンジ療法の検討2013

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、淺沼邦洋、中村知樹、内田淳正、須藤啓広
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域在住高齢者に対するロコモ25とロコモティブシンドロームとの関係2013

    • Author(s)
      西村明展、松峯昭彦、長谷川正裕、若林弘樹、明田浩司、淺沼邦洋、辻井雅也、里中東彦、松原孝夫、加藤公、須藤啓広
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊椎椎体骨折の追跡調査―既存骨折に対する新規骨折の発生様式―2013

    • Author(s)
      加藤俊宏、明田浩司、西村明展、松峯昭彦、長谷川正裕、若林弘樹、辻井雅也、淺沼邦洋、松原孝夫、中村知樹、須藤啓広
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腫瘍用人工関節再置換の手技的問題点-感染症例に対する治療を中心に-2013

    • Author(s)
      松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、大井 徹、後藤幹伸、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん治療における整形外科医の重要性-Tumor Boardでの検討症例から-2013

    • Author(s)
      松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、大井 徹、後藤幹伸、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膝蓋骨-膝蓋腱-脛骨近位の術中加温/放射線処理により膝伸展機構を再建した膝前面軟部肉腫の3例2013

    • Author(s)
      松峯昭彦、辻井雅也、植村 剛、松原孝夫、淺沼邦洋、中村知樹、大井 徹、後藤幹伸、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨・軟部腫瘍手術でDVT予防の抗凝固療法は必要か2013

    • Author(s)
      淺沼邦洋、松峯昭彦、山口敏郎、長谷川正裕、松原孝夫、中村知樹、宮本 憲、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟部肉腫に対するアクリジンオレンジ療法および術前化学療法兼用療法の治療成績2013

    • Author(s)
      松原孝夫、楠崎克之、松峯昭彦、淺沼邦洋、中村知樹、内田淳正、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多発肺転移に対してラジオ波焼灼術を行い長期生存が得られている軟骨肉腫の1例2013

    • Author(s)
      中村知樹、松峯昭彦、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟部肉腫における血清CRPの臨床的意義2013

    • Author(s)
      中村知樹、松峯昭彦、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超高齢発症の悪性骨・軟部腫瘍の治療成績2013

    • Author(s)
      大井 徹、松峯昭彦、後藤幹伸、中村知樹、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血清可溶型CD155量は、悪性骨・軟部腫瘍患者の予後予測に有用である2013

    • Author(s)
      後藤幹伸、松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、大井 徹、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 転移性骨・軟部腫瘍に対するCT透視下凍結療法の初期経験2013

    • Author(s)
      中塚豊真、山門享一郎、高木治行、浦城淳二、山中隆嗣、藤森将志、長谷川貴章、佐久間肇、松峯昭彦、須藤啓広
    • Organizer
      第46回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 右胸壁に生じた放射線皮膚潰瘍に対して対側の内胸動脈穿通枝皮弁で加療した1例2013

    • Author(s)
      横山弘和、辻井雅也、國分直樹、大角秀彦、松峯昭彦、須藤啓広
    • Organizer
      日本マイクロサージャリー学会40周年記念学術集会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線処理脛骨の近位骨端線離開に対して逆行性血管柄付き大腿骨内顆骨弁を施行した1例2013

    • Author(s)
      萩 智仁、辻井雅也、里中東彦、植村 剛、國分直樹、横山弘和、松峯昭彦、須藤啓広
    • Organizer
      日本マイクロサージャリー学会40周年記念学術集会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟部腫瘍における血中fibrinogen値の検討2013

    • Author(s)
      淺沼邦洋、中村知樹、松峯昭彦、松原孝夫、大井 徹、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 長管骨難治性骨巨細胞腫の治療成績2013

    • Author(s)
      松原孝夫、松峯昭彦、淺沼邦洋、中村知樹、奥野一真、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肺転移に対してラジオ波焼灼術を行った高齢者(65歳以上)骨軟部肉腫の治療成績2013

    • Author(s)
      中村知樹、松峯昭彦、山門享一郎、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超高齢発症の四肢悪性軟部腫瘍の治療成績2013

    • Author(s)
      大井 徹、松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肋骨を合併切除した胸壁発生軟部肉腫5例の治療成績2013

    • Author(s)
      後藤幹伸、松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨外病変を伴った大腿骨近位悪性骨腫瘍における腫瘍用人工関節置換術後の患肢機能の検討2013

    • Author(s)
      奥野一真、松原孝夫、中村知樹、淺沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上腕皮下に発生した骨外性骨肉腫の1例2013

    • Author(s)
      浅野貴裕、中村知樹、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨腫瘍と鑑別を要した特発性大腿骨頭壊死症の一例2013

    • Author(s)
      宮村 岳、長谷川正裕、吉田格之進、若林弘樹、松峯昭彦、須藤啓広
    • Organizer
      第121回中部日本整形外科災害外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 薬物ライブラリを用いた骨肉腫に対する新規治療薬の探索2013

    • Author(s)
      大井 徹、淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、飯野隆大、後藤幹伸、須藤啓広
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肉腫細胞においてCD155は細胞外に分泌されており、悪性骨・軟部腫瘍患者の有用なバイオマーカーとなりうる2013

    • Author(s)
      後藤幹伸、松峯昭彦、飯野隆大、大井 徹、中村知樹、松原孝夫、淺沼邦洋、須藤啓広
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性骨・軟部腫瘍における血清中EXT1タンパクの意義2013

    • Author(s)
      飯野隆大、松峯昭彦、後藤幹伸、淺沼邦洋、松原孝夫、中村知樹、須藤啓広
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性軟部腫瘍に対するパゾパニブの治療効果2013

    • Author(s)
      松峯昭彦
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Soluble N-cadherin as a Biomarker for Malignant Bone and Soft Tissue Tumor2012

    • Author(s)
      Matsumine A, Niimi R, Iino T, Nakazora S, Nakamura T, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Organizer
      17) 9TH ASIS PACIFIC MUSCULOSKELETAL TUMOR SOCIETY MEETING 2012 Connectine Tissue Oncology Society
    • Place of Presentation
      Czech Republic, Prague
    • Related Report
      2013 Final Research Report
  • [Presentation] The Expression of Thrombomodulin Messenger RNA in 62 Soft Tissue Sarcoma Patients2012

    • Author(s)
      Asanuma K, Matsumine A, Matsubara T, Nakamura T, Uchida A, Sudo A
    • Organizer
      9TH ASIS PACIFIC MUSCULOSKELETAL TUMOR SOCIETY MEETING 2012 Connectine Tissue Oncology Society
    • Place of Presentation
      Czech Republic, Prague
    • Related Report
      2013 Final Research Report
  • [Presentation] A Minimally Invasive Surgery for Bone Metastases Using the Combination of Photodynamic Therapy and Hyperthermia Treatment2012

    • Author(s)
      Matsubara T, Kusuzaki K, Matsumine A, Asanuma K, Nakamura T, Uchida A, Sudo A
    • Organizer
      9TH ASIS PACIFIC MUSCULOSKELETAL TUMOR SOCIETY MEETING 2012 Connectine Tissue Oncology Society
    • Place of Presentation
      Czech Republic, Prague
    • Related Report
      2013 Final Research Report
  • [Presentation] Tissue Factor Mrna Expression in 68 Soft Tissue Sarcoma Patients2012

    • Author(s)
      Asanuma K, Matsumine A, Matsubara T, Atsumi S, Matsui Y, Nakamura T, Uchida A, Sudo A
    • Organizer
      Combined 33rd SICOT & 17th PAOA Orthopaedic World Conference
    • Place of Presentation
      Dubai, United Arab Emirates
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of tumor metastatic factor using low coagulation activity model in mice2012

    • Author(s)
      Asanuma K, Matsumine A, Asanuma Y, Akita N, Yoshikawa T, Yoshida K, Matsubara T, Nakamura T, Okamoto T, Hayashi T, Uchida A, Sudo A
    • Organizer
      13) Orthopaedic Research Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma2012

    • Author(s)
      Atsumi S, Matsumine A, Nakamura T, Niini R, Matsubara T, Asanuma K, Uchida A, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma2012

    • Author(s)
      Satanaka H, Akeda K, Kusuzaki K, Tujii M, Iino T, Uemura T, Nakamura T, Matsubara T, Asanuma K, Matsumine A, Sudo A
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Oncolytic virotherapy for human bone and soft tissue sarcomas using live-attenuated poliovirus2012

    • Author(s)
      Matsumine A
    • Organizer
      9TH ASIS PACIFIC MUSCULOSKELETAL TUMOR SOCIETY MEETING 2012
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2012 Research-status Report
  • [Presentation] 弱毒ポリオ生ワクチンによる骨・軟部肉腫に対する抗腫瘍効果の機序の検討2012

    • Author(s)
      渥美 覚、松峯昭彦、新美 塁、中村知樹、松原孝夫、淺沼邦洋、豊田秀実、駒田美弘、内田淳正、須藤啓広
    • Organizer
      第45回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 弱毒ポリオ生ワクチンを用いた悪性骨軟部腫瘍に対する腫瘍融解療法2012

    • Author(s)
      松峯昭彦、渥美覚、新美塁、中村知樹、松原孝夫、淺沼邦洋、飯野隆大、豊田秀実、駒田美弘、内田淳正、須藤啓広
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Related Report
      2012 Research-status Report
  • [Presentation] 弱毒ポリオ生ワクチンを用いた悪性・骨軟部腫瘍に対する腫瘍融解療法2012

    • Author(s)
      松峯昭彦、渥美覚、新美塁、中村知樹、松原孝夫、淺沼邦洋、飯野隆大、豊田秀実、駒田美弘、内田淳正、須藤啓広
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma.2012

    • Author(s)
      S. Atsumi, A. Matsumine, Y. Asanuma, N. Akita, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, T. Okamoto, T. Hayashi, A. Uchida, A. Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of tumor metastatic using low coagulation activity model in mice.2012

    • Author(s)
      K. Asanuma, A. Matsumine, Y. Asanuma, N. Akita, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, T. Okamoto, Tatsuya Hayashi, A. Uchida, A. Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma.2012

    • Author(s)
      H. Satanaka, K. Akeda, K. Kusuzaki, M. Tujii, T. Iino, T. Uemura, T. Nakamura, T. Matsubara, K. Asanuma, A. Matsumine, A. Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] Infliximab suppresses the lung metastasis in osteosarcoma cell line.2012

    • Author(s)
      H. Kato, H. Wakabayashi, A. Matsumine, A. Sudo.
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      California
    • Related Report
      2011 Research-status Report
  • [Presentation] The inhibition of lung metastasis by inactivation of coagulation activity may lead to dissemination of tumor cells.2011

    • Author(s)
      K. Asanuma, A. Matsumine, Y. Asanuma, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, A. Uchida, A. Sudo.
    • Organizer
      EUROPEAN ORTHOPAEDIC RESEACH SOCIETY
    • Place of Presentation
      Austria
    • Related Report
      2011 Research-status Report
  • [Presentation] 軟部肉腫における診断の遅延が臨床経過に及ぼす影響.2011

    • Author(s)
      中村知樹、松峯昭彦、松原孝夫、淺沼邦洋、渥美覚、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 低悪性度軟骨肉腫の治療成績.2011

    • Author(s)
      渥美覚、松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 下肢骨・軟部腫瘍術後の深部静脈血栓症の発生率と危険因子について.2011

    • Author(s)
      山口敏郎、松峯昭彦、施徳全、新美塁、中村知樹、松原孝夫、淺沼邦洋、長谷川正裕、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] アクリジンオレンジを用いた分子イメージングの低侵襲外科手術への応用.2011

    • Author(s)
      楠崎克之、松原孝夫、里中東彦、中村知樹、松峯昭彦、須藤啓広、内田淳正.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 京セラ腫瘍用人工膝関節:PHK IIIの治療成績に関する追加調査報告 ―骨軟部肉腫治療研究会(JMOG)による多施設共同研究―2011

    • Author(s)
      松峯昭彦、上田孝文、杉田孝、矢澤康男、井須和男、平賀博明、川井章、阿部哲士、薬師寺俊剛、淺沼邦洋、松原孝夫、中村知樹、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] 悪性骨・軟部腫瘍切除後の骨欠損に対する術中処理自家骨移植法の治療成績.2011

    • Author(s)
      松原孝夫、松峯昭彦、楠崎克之、中村知樹、淺沼邦洋、渥美覚、内田淳正、須藤啓広.
    • Organizer
      第44回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] マグネタイト含有リン酸カルシウム骨ペーストを用いた難治性骨腫瘍に対する温熱療法.2011

    • Author(s)
      松峯昭彦、淺沼邦洋、松原孝夫、中村知樹、渥美覚、内田淳正、須藤啓広.
    • Organizer
      日本ハイパーサミーア学会 第28回大会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 体外交流電磁場発生装置を用いた転移性骨腫瘍に対する電磁性体温熱療法.2011

    • Author(s)
      松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、内田淳正、須藤啓広.
    • Organizer
      日本ハイパーサミーア学会 第28回大会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] Ewing肉腫における新規腫瘍マーカーの探索:ADAMTS4発現の診断的意義の解析.2011

    • Author(s)
      美濃部こころ、松峯昭彦、小埜良一、飯野隆大、林泰秀、北村俊雄、内田淳正、須藤啓広、野板哲哉.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 血液凝固抑制マウスを用いた肺転移関連因子の解析2011

    • Author(s)
      淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、吉川智朗、淺沼由美子、内田淳正、林辰弥、秋田展幸、岡本貴之、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] Dupuytren拘縮に対するアクリジンオレンジ光線力学的療法の殺細胞効果.2011

    • Author(s)
      里中東彦、辻井雅也、飯田竜、堀和一郎、植村剛、長谷川正裕、飯野隆大、松峯昭彦、楠崎克之、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 軟骨細胞分化にはN-カドヘリンの切断が必須である.2011

    • Author(s)
      中空繁登、松峯昭彦、飯野隆大、若林徹、長谷川正裕、内田淳正、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 高齢者の要介護認定に対する変形性膝関節症と骨粗鬆症の影響―旧宮川村検診より―2011

    • Author(s)
      西村明展、松峯昭彦、長谷川正裕、若林弘樹、明田浩司、淺沼邦洋、辻井雅也、里中東彦、松原孝夫、中村知樹、山田知美、加藤公、内田淳正、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 弱毒ポリオ生ワクチンによる悪性骨・軟部腫瘍の新しい腫瘍融解療法.2011

    • Author(s)
      渥美覚、松峯昭彦、新美塁、中村知樹、松原孝夫、淺沼邦洋、豊田秀美、駒田美弘、内田淳正、須藤啓広.
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report
  • [Presentation] 下腿遠位部悪性骨腫瘍に対する処理骨を用いた患肢温存の治療成績.2011

    • Author(s)
      松井佑梨世、中村知樹、松原孝夫、淺沼邦洋、松峯昭彦、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 大腿骨近位部の悪性骨軟部腫瘍に対する腫瘍用人工関節の治療成績.2011

    • Author(s)
      淺沼邦洋、松峯昭彦、松原孝夫、中村知樹、内田淳正、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 抗菌薬充填ハイドロキシアパタイトと有茎皮弁による脛骨慢性骨髄炎の治療.2011

    • Author(s)
      辻井雅也、里中東彦、植村剛、松岡宏明、松峯昭彦、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 血腫と診断された腫瘤の臨床および画像所見的特徴.2011

    • Author(s)
      渥美覚、松峯昭彦、中村知樹、松原孝夫、淺沼邦洋、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 膝蓋靱帯・アキレス腱周囲に発生した悪性軟部腫瘍手術における術中自家腱処理法.2011

    • Author(s)
      松原孝夫、松峯昭彦、淺沼邦洋、中村知樹、渥美覚、須藤啓広.
    • Organizer
      第117回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      宇部市
    • Related Report
      2011 Research-status Report
  • [Presentation] 血管柄付き骨移植術を用いた上肢再建の経験.2011

    • Author(s)
      辻井雅也、平田仁、里中東彦、植村剛、吉川智朗、海野宏至、石黒茂夫、飯田竜、中村知樹、松峯昭彦、須藤啓広.
    • Organizer
      第38回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      新潟市
    • Related Report
      2011 Research-status Report
  • [Presentation] 示指動静脈奇形に対して爪を含めたhemipulp flapにて再建した1例.2011

    • Author(s)
      海野宏至、辻井雅也、森田哲正、植村剛、里中東彦、松峯昭彦、須藤啓広.
    • Organizer
      第38回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      新潟市
    • Related Report
      2011 Research-status Report
  • [Presentation] 軸椎に発生した原発性平滑筋肉腫の1例.2011

    • Author(s)
      山田淳一、明田浩司、松峯昭彦、須藤啓広、榊原紀彦、笠井裕一、藤井渉、福島達樹.
    • Organizer
      第76回東海脊椎脊髄病研究会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Book] 先端医療シリーズ44、臨床医のための最新整形外科、軟部肉腫に対するアクリジンオレンジ療法2013

    • Author(s)
      松峯昭彦、松原孝夫、楠崎克之
    • Total Pages
      570
    • Publisher
      先端医療技術研究所
    • Related Report
      2013 Final Research Report
  • [Book] がん骨転移のバイオロジーとマネージメント、Part iiがん骨転移のマネージメント、疫学~骨関連事象、予後など~2012

    • Author(s)
      湏藤啓広、松峯昭彦
    • Total Pages
      400
    • Publisher
      医薬ジャーナル
    • Related Report
      2013 Final Research Report
  • [Book] Chapter VI : New concept of limb salvage surgery in musculoskeletal sarcomas with acridine orange therapy2012

    • Author(s)
      Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y
    • Total Pages
      179
    • Publisher
      Nova Science Publishers
    • Related Report
      2013 Final Research Report
  • [Book] 整形外科臨床パサージュ6、軟部腫瘍プラクティカルガイド、軟部腫瘍における生検の実際2011

    • Author(s)
      松峯昭彦
    • Total Pages
      240
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] 薬局増刊号、病気と薬パーフェクトBOOK,骨肉腫2011

    • Author(s)
      松原孝夫、松峯昭彦、須藤啓広
    • Total Pages
      1928
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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