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Investigation for gene regulating factors in articular cartilage degeneration

Research Project

Project/Area Number 23592218
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

OKAZAKI KEN  九州大学, 大学病院, 講師 (10398092)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords関節炎 / 軟骨 / 遺伝子発現 / 転写因子 / 軟骨代謝 / 軟骨分化 / 破骨細胞 / 骨破壊 / 軟骨変性 / 変形性関節症 / 関節リウマチ
Research Abstract

We found that a transcriptional factor, C/EBP plays crucial roles in gene regulation which affect cartilage degeneration in osteoarthritis or rheumatoid arthritis. C/EBP stimulates gene expressions of MMP1, MMP-3, MMP-13, which denature the cartilage matrix. C/EBP also stimulate RANKL expression to promote osteoclast formation that consequently promote bone destruction in rheumatoid arthritis. Furthermore, C/EBP repress the expression of type II collagen which is a major matrix molecule of cartilage.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (8 results) (of which Invited: 1 results)

  • [Journal Article] CCAAT/enhancer binding proteinβregulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes2014

    • Author(s)
      Ushijima T, Okazaki K, Tsushima H, Iwamoto Y
    • Journal Title

      J Biol Chem

      Volume: 289(5) Pages: 2852-63

    • Related Report
      2013 Final Research Report
  • [Journal Article] CCAAT/enhancer binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes2014

    • Author(s)
      Ushijima T, Okazaki K, Tsushima H, Iwamoto Y
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 5 Pages: 2852-2863

    • DOI

      10.1074/jbc.m113.492843

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T1ρis superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis : Radiological-pathological correlation after total knee arthroplasty2013

    • Author(s)
      Takayama Y, Hatakenaka M, Tsushima H, Okazaki K, Yoshiura T, Yonezawa M, Nishikawa K, Iwamoto Y, Honda H
    • Journal Title

      Eur J Radiol

      Volume: 82(4) Issue: 4 Pages: e192-e198

    • DOI

      10.1016/j.ejrad.2012.11.031

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 変形性膝関節症の病態生理と診断2013

    • Author(s)
      岡崎賢
    • Journal Title

      整形外科看護

      Volume: 18(8) Pages: 722-731

    • Related Report
      2013 Final Research Report
  • [Journal Article] CCAAT/enhancer binding proteinβregulates expression of matrix metalloproteinase-3 in arthritis2012

    • Author(s)
      Tsushima H, Okazaki K, Hayashida M, Ushijima T, Iwamoto Y
    • Journal Title

      Ann Rheum Dis

      Volume: 71 Pages: 99-107

    • NAID

      120005324439

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of cartilage degradation in arthritis using T1ρ magnetic resonance imaging mapping2012

    • Author(s)
      Tsushima H, Okazaki K, Takayama Y, Hatakenaka M, Honda H, Izawa T, Nakashima Y, Yamada H, Iwamoto Y
    • Journal Title

      Rheumatology international

      Volume: 32 Issue: 9 Pages: 2867-2875

    • DOI

      10.1007/s00296-011-2140-3

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 関節リウマチ・変形性関節症の軟骨変性における遺伝子発現の制御2012

    • Author(s)
      岡崎賢, 岩本幸英
    • Journal Title

      福岡医学雑誌

      Volume: 103(9) Pages: 175-180

    • NAID

      40019478942

    • Related Report
      2013 Final Research Report
  • [Journal Article] CCAAT/enhancer binding protein β regulates expression of matrix metalloproteinase-3 in arthritis2012

    • Author(s)
      Tsushima H, Okazaki K, Hayashida M, Ushijima T, Iwamoto Y
    • Journal Title

      Annals of Rheumatic Diseases

      Volume: 71 Issue: 1 Pages: 99-107

    • DOI

      10.1136/annrheumdis-2011-200061

    • NAID

      120005324439

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 軟骨分化におけるCCAAT/enhancer-binding proteinβの関わり2014

    • Author(s)
      岡崎賢、牛島貴宏、津嶋秀俊、林田光正、岩本幸英
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟骨分化におけるCCAAT/enhancer-binding protein βの関わり2014

    • Author(s)
      岡崎 賢、牛島貴宏、津嶋秀俊、林田光正、岩本幸英
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 軟骨分化においてCCAAT/enhancer-binding protein βはindian hedgehogの発現を調節する2014

    • Author(s)
      牛島貴宏、岡崎 賢、津嶋秀俊、岩本幸英
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] CCAAT/enchancer-binding protein beta promotes osteoclast differentiation through RANKL expression from synovial fibroblast like cells in rheumatoid arthritis2013

    • Author(s)
      Tsushima H, Okazaki K, Ushijima T, Iwamoto Y
    • Organizer
      2013 annal meeting of orthopaedic research society
    • Place of Presentation
      San Antonio, TX, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] CCAAT/enhancer-binding protein beta regulates phenotypic conversion from proliferative to hypertrophic chondrocytes during endochondral ossification2013

    • Author(s)
      Ushijima T, Okazaki K, Tsushima H, Iwamoto Y
    • Organizer
      2013 annual meeting of orthopaedic research society
    • Place of Presentation
      San Antonio, TX, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 関節炎における転写制御と軟骨破壊2011

    • Author(s)
      岡崎賢、津嶋秀俊、牛島貴宏、岩本幸英
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene regulation of cartilage degeneration in osteoarthritis2011

    • Author(s)
      Okazaki K, Tsushima H, Hayashida M, Ushijima T, Iwamoto Y
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 関節炎における転写制御と軟骨破壊2011

    • Author(s)
      岡崎 賢、津嶋秀俊、牛島貴宏、岩本幸英
    • Organizer
      第26回日本整形外科学会基礎学術集会(招待講演)
    • Place of Presentation
      前橋市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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