Evaluation of Glutamate and GABA in the Anterior Cingulate Gyrus of Chronic Pain Patients with MR Spectroscopy
| Project/Area Number |
23592284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
FUKUI sei 滋賀医科大学, 医学部, 講師 (80303783)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | MR spectroscopy / 前帯状回 / NAA / GABA / Glutamate / 慢性痛 / VBM / 局所脳神経機能 / MRスペクトロスコピー / Nアセチルアスパラギン酸 / 慢性腰痛 / Voxel-based morphometry / MR Spectroscopy |
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| Research Abstract |
The main objective of this study is to determine how chronic pain can induce changes in nerve activity in the ACC using proton MRS. The N-acetylaspartate (NAA), glutamate(Glu), and GABA levels in the regions were determined from the spectral peaks, using 3-tesla MR device equipped with an MRS analytical device. The NAA, Glu, and GABA levels were then compared between the patient and control groups.
The NAA and GABA levels in the ACC were significantly decreased in the chronic pain patient group compared to those in the control group. It was suggested that decreased inhibitory neurotransmission efficiency in the anterior cingulate gyrus is involved in the pathology of chronic pain.
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Report
(4 results)
Research Products
(31 results)
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[Book] 脳２１2014
Author(s)
岩下成人、野坂修一、福井 聖
Total Pages
6
Publisher
金芳堂
Related Report
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