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The mechanism of action of aconite and botulinum toxin for interstitial cystitis pain

Research Project

Project/Area Number 23592362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionUniversity of Yamanashi

Principal Investigator

TSUCHIDA Takayuki  山梨大学, 医学部附属病院, 講師 (30217327)

Co-Investigator(Kenkyū-buntansha) TAKEDA Masayuki  山梨大学, 医学工学総合研究部, 教授 (80197318)
MIYAMOTO Tatsuya  山梨大学, 医学部附属病院, 医員 (80456459)
KOBAYASHI Hideki  山梨大学, 医学工学総合研究部, 助教 (50402053)
NAKAGOMI Hiroshi  山梨大学, 医学部附属病院, 助教 (80418714)
YOSHIYAMA Mitsuharu  山梨大学, 医学工学総合研究部, 教授 (20422694)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords間質性膀胱炎 / 漢方治療 / ボツリヌストキシン / 附子(トリカブト) / トリカブト / ボツリヌス毒素 / 神経障害性疼痛 / 慢性疼痛症候群 / 漢方 / 附子 / ペインコントロール / 国際情報交流 / 多国籍
Research Abstract

The present study aimed to test whether the analgesic properties of Kampo medicine may provide long-term pain relief and satisfaction with a single hydrodistention for these patients.The 3-year efficacy of the treatment was evaluated using the visual analogue scale questionnaire, the real-time visual analogue scale, and the quality of life questionnaireThe present study demonstrates that Kampo medicine is a safe and effective analgesic for interstitial cystitis patients and results in a significant improvement in their quality of life.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011 Other

All Journal Article (1 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] ボツリヌス毒素(BTX)を用いた排尿障害の治療2011

    • Author(s)
      土田孝之
    • Journal Title

      神経・筋疾患に関するボツリヌス療法研究会会誌

      Volume: 1 Pages: 7-10

    • Related Report
      2011 Research-status Report
  • [Presentation] 間質性膀胱炎の頻尿と膀胱痛の長期改善、安定化に対してのOAB治療薬mirabegronと漢方の併用療法2013

    • Author(s)
      東慧、土田孝之、大竹裕子、井上千尋、吉良聡、山岸敬、宮本達也、羽根田破、神家満学、小林英樹、武田正之
    • Organizer
      第20回日本排尿機能学会
    • Place of Presentation
      静岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of the beta3-adrenoceptor agonist mirabegron in patients with stress urinary incontinence2013

    • Author(s)
      小林英樹、羽根田破、大竹裕子、工藤祥司、土田孝之、芳山充晴、荒木勇雄
    • Organizer
      The 43th Annual Meeting of International Continence Society
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Final Research Report
  • [Presentation] Beta3-adenoceptor agonist, Mirabegron : A Novel Medical Therapy for Lower Urinary Tract Systems in Patients with Interstitial Cystitis2013

    • Author(s)
      土田孝之、井上千尋、大竹裕子、羽根田破、小林英樹、宮本達也、武田正之
    • Organizer
      The 43th Annual Meeting of International Continence Society
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Final Research Report
  • [Presentation] 間質性膀胱炎症例の膀胱充満時痛・頻尿に対するミラベグロンの有用性の検討2013

    • Author(s)
      大竹裕子、土田孝之、羽根田破、小林英樹、井上千尋、宮本達也、吉良聡、武田正之
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 間質性膀胱炎症例の膀胱充満時痛・頻尿に対するミラベグロンの有用性の検討2013

    • Author(s)
      東 慧
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      さっぽろ芸術文化の館(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 間質性膀胱炎の頻尿と膀胱痛の長期改善、安定化に対してのOAB治療薬mirabegronと漢方の併用療法2013

    • Author(s)
      東 慧
    • Organizer
      第20回日本排尿機能学会
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Beta3-adrenoceptor agonist, Mirabegron: A Novel Medical Therapy for Lower Urinary Tract Symptoms in Patients with Interstitial Cystitis2013

    • Author(s)
      土田孝之
    • Organizer
      The 43th Annual Meeting of International Continence Society
    • Place of Presentation
      インターナショナルコンベンションセンター(バルセロナ,スペイン)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 難治性頻尿に対してのベタニスの使用経験2012

    • Author(s)
      大竹裕子、土田孝之
    • Organizer
      第19回日本排尿機能学会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2012 Research-status Report
  • [Presentation] 間質性膀胱炎/慢性骨盤痛症候群50例に対して、疼痛コントロールを可能にした漢方を中心にした治療2012

    • Author(s)
      土田孝之
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Research-status Report
  • [Presentation] VNUT plays an important role in vesicular storage and subsequent exocytosis of ATP from bladder epithelium upon mechanical stretch stimulation2011

    • Author(s)
      中込宙史
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] VNUT PLAYS AN IMPORTANT ROLE IN VESICULAR STORAGE AND SUBSEQUENT EXOCYTOSIS OF ATP FROM BLADDER EPITHELIUM UPON MECHANICAL STRETCH STIMULATION2011

    • Author(s)
      中込宙史
    • Organizer
      41st ANNUAL MEETING OF THE INTERNATIONAL CONTINENCE SOCIETY (ICS)
    • Place of Presentation
      Scotish Exhibition&conference Center(Glasgow,UK)
    • Related Report
      2011 Research-status Report
  • [Remarks] なし

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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