| Project/Area Number |
23592364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Tomoaki 信州大学, 医学部附属病院, 助教 (30293525)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 冷えストレス / 国際前立腺症状スコア / 過活動膀胱症状スコア / アドレナリン受容体 / 膀胱粘膜 / セロトニン受容体 / 大建中湯 / 過活動膀胱症状質問票 / セロトニン |
|---|
| Research Abstract |
Lower urinary tract symptoms(LUTS) induced by cold stress has not been sufficiently studied. Autonomic nervous system receptors mRNA were analyzed in bladder mucosa of patients with LUTS/benign prostatic obstruction. There was an increased expression of alpha 1d-AR, beta 3 AR, serotonin 2b, 3a, 7 mRNA in the bladder mucosa. Serotonin mechanism may take a role in LUTS induced by cold stress. 50 people who visited a public health management seminar were studied. The participants were devided into two groups-cold sensitive and non-sensitive- according to self-described sensitivity to cold stress. Daily exercise and lifestyle modification was effective for LUTS in cold sensitive people. Daikenchuto, a pharmaceutical-grade traditional Japanese medicine, were administered to the refratory LUTS patients with constipation or cold sensitivity. Daikenchuto improved LUTS suggesting as a consequence of improvement of constipation or cold sensitivity.
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