Basic and clinical aspects of LUTS induced by cold stress
Project/Area Number |
23592364
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TANABE Tomoaki 信州大学, 医学部附属病院, 助教 (30293525)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 冷えストレス / 国際前立腺症状スコア / 過活動膀胱症状スコア / アドレナリン受容体 / 膀胱粘膜 / セロトニン受容体 / 大建中湯 / 過活動膀胱症状質問票 / セロトニン |
Research Abstract |
Lower urinary tract symptoms(LUTS) induced by cold stress has not been sufficiently studied. Autonomic nervous system receptors mRNA were analyzed in bladder mucosa of patients with LUTS/benign prostatic obstruction. There was an increased expression of alpha 1d-AR, beta 3 AR, serotonin 2b, 3a, 7 mRNA in the bladder mucosa. Serotonin mechanism may take a role in LUTS induced by cold stress. 50 people who visited a public health management seminar were studied. The participants were devided into two groups-cold sensitive and non-sensitive- according to self-described sensitivity to cold stress. Daily exercise and lifestyle modification was effective for LUTS in cold sensitive people. Daikenchuto, a pharmaceutical-grade traditional Japanese medicine, were administered to the refratory LUTS patients with constipation or cold sensitivity. Daikenchuto improved LUTS suggesting as a consequence of improvement of constipation or cold sensitivity.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Alpha1-adrenergic receptors mediate bladder overactivity induced by cold stress in rats with bladder outlet obstruction2014
Author(s)
Yamagishi, T., Ishizuka, O., Imamura, T., Yokoyama, H., Ogawa, T., Kurizaki, Y., Nishizawa, O., Andersson, K.-E.
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Journal Title
Neurourol. Urodyn
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] The relationship between toe temperature and lower urinary tract symptoms2012
Author(s)
Inoue, H., Ishizuka, O., Imamura, T., Yamagishi, T., Noguchi, W., Yokoyama, H., Kurizaki, Y., Nishizawa, O.
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Journal Title
LUTS
Volume: 4
Pages: 144-149
Related Report
Peer Reviewed
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[Journal Article] The relationship between toe temperature and lower urinary tract symptoms.2012
Author(s)
Inoue, H., Ishizuka, O., Imamura, T., Yamagishi, T., Noguchi, W., Yokoyama, H., Kurizaki, Y., Nishizawa, O
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Journal Title
LUTS
Volume: 4
Pages: 144-149
Related Report
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[Presentation] Alpha1D-adrenergic plays important role for cold stress-induced detrusor overactivity in rats with bladder outlet obstruction2013
Author(s)
Yamagishi, T., Ishizuka, O., Imamura, T., Noguchi, W., Yokoyama, H., Kurizaki, Y., Nishizawa, O.
Organizer
108^<th> of the Annual meeting of the American urological association
Place of Presentation
San Diego
Year and Date
2013-05-04
Related Report
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[Presentation] Effects of herbal medicine Daikenchuto on patients of refractory overactive bladder or lower urinary tract symptoms with constipation or hypersensitivity to cold2013
Author(s)
Minagawa, T., Noguchi,W., Ogawa, T., Imamura, T., Kato, H., Ishizuka, O., Nishizawa, O.
Organizer
43^<rd> of the Annual meeting of the International continence society
Place of Presentation
Barcelona
Related Report
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[Presentation] 下部尿路症状と下肢温度との関係についての検討2012
Author(s)
山岸貴裕,石塚修,今村哲也,井上博夫,野口渉,横山仁,栗崎功己,小川輝之,石川雅邦,市野みどり,西澤理
Organizer
第19回日本排尿機能学会
Place of Presentation
名古屋
Year and Date
2012-08-30
Related Report
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