A study to examine the renal protective effect and the remote effect of ischemic preconditioning for renal ischemia/reperfusion injury
| Project/Area Number |
23592380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Horo-omi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10214446)
TAKAHASHI Masayuki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (50325255)
FUKUMORI Tomoharu 徳島大学, 病院, 講師 (10314874)
NAKATSUJI Hiroyoshi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 非常勤講師 (50437638)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腎虚血再灌流障害 / ischemic preconditioning / remoteorgen ischemic / 腹腔境下腎部分切除 / 心筋保護作用 / remotergan ischemic / 腹腔境下腎部分切除術 / remoteorgan ischemic |
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| Research Abstract |
We made a rat model of renal ischemia/reperfusion and examined the effectiveness of ischemic preconditioning for preventing renal ischemia/reperfusion injury. We also sought to reveal the underlying mechanism of ischemic preconditioning.
We found that ischemic preconditioning could efficiently reduce the damage for uriniferous tubules by renal ischemia/reperfusion. We focused on Preconditioning inducible factor-A (PICA) as a factor that is related to the damage of uriniferous tubules after renal ischemia/reperfusion according to the results of comprehensive gene expression analyses with DNA microarray. We found that the expression of this gene was conspicuously elevated at mRNA and protein level in HK2 cells when the cells were exposed to the hypoxic condition. As this gene was shown to regulate the molecules that are related to endoplasmic reticulum stress, we are in progress for analyzing the relationship of this gene and endoplasmic reticulum stress.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Substitution of anti-androgens and tegafur-uracil combination therapy for castration-resistant prostate cancer:Result of a multi-center randomized phase II study2013
Author(s)
MASAYUKI TAKAHASHI, TAKAHASHI,RUMI KAWABATA,AKIRA KAWANO,TOSHIHIDE MURAKAMI,YASUSHI SUTOU,TOHRU INAI,SEIJI AKAZAWA,TAKUMI HAMAO,HIDEKI HAYASHI,TOKMOYA FUKAWA,MASAHIKO TAKEMURA,YASUYO YAMAMOTO,KUNIHISA YAMAGUCHI,HIROFUMI IZAKI,TOMOHARU FUKUMORI and HIROOMI KANAYAMA
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Journal Title
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume: 43
Issue: 3
Pages: 713-720
DOI
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Peer Reviewed
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[Presentation] DDX31 regulates p53 tumor suppressor activity through its interaction with NPM1 in renal cell carcinomas2013
Author(s)
Tomoya Fukawa,Taisuke Matsuo, Masahiko Takemura,Yasuyo Yamamoto,Kunihisa Yamaguchi,Hisaya Takahashi,hirofumi Izaki,Masayuki Takahashi,Tomoharu Fukumori,Toyomasa Katagiri,Hiro-omi Kanayama
Place of Presentation
Convention Center(SANDIEGO,USA)
Year and Date
2013-05-04
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[Presentation] 膀胱癌におけるPlakophjilin-2とPlakophilin-3の関与2013
Author(s)
高橋久弥,高橋正幸,小森政嗣,香川純一郎,仙崎智一,布川朋也,武村政彦,山本恭代,山口邦久,中逵弘能,井崎博文,福森知治,金山博臣
Organizer
日本泌尿器科学会総会
Place of Presentation
ロイトン札幌・札幌市教育文化会館・札幌プリンスホテル国際館パミール(北海道)
Year and Date
2013-04-25
Related Report
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[Presentation] Enhancement of osteoclastogenic activity in osteolytic prostate cancer cells by physical contact with osteoblasts2011
Author(s)
S Avilmed,Uehara H, Nakatsiji H, Fukawa T, Takemura M, Yamamoto Y, Yamaguchi K, Kishimot T, Izaki H, Takahashi M, Fukumori T, Kanayama H
Organizer
AUA
Place of Presentation
Convention Center (Washington DC,USA)
Year and Date
2011-05-14
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Author(s)
アビルメド・シーレンヤンバ,中逵弘能,津田恵,布川朋也,武村政彦,山本恭代,山口邦久,岸本大輝,井崎博文,高橋正幸,福森知治,金山博臣
Organizer
日本泌尿器科学会総会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2011-04-21
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Author(s)
中逵弘能,シーレンヤンバアビルメド,津田恵,布川朋也,武村政彦,山本恭代,山口邦久,岸本大輝,井崎博文,高橋正幸,福森知治,金山博臣
Organizer
日本泌尿器科学会総会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2011-04-21
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[Presentation] MicroRNAs are reproducibly deregulated in prostate carcinoma and are potential regulators of signal transduction pathways like PI3-kinase or MAP-kinase pathways2011
Author(s)
S Avirmed,Uehara H,Nakatsiji H,Fukawa T,Takemura M,Yamamoto Y,Yamaguchi K Kishimot T,Izaki H,Takahashi M,Fukumori T,Kanayama H
Organizer
EAU
Place of Presentation
Centre Vienna (Vienna,Austria)
Year and Date
2011-03-18
Related Report
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