Prediction, prevention and treatment of preeclampsia by measuring and controlling angiogenic factors

• Project/Area Number: 23592396
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: KOGA Kaori 東京大学, 医学部附属病院, 講師 (10396723)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 血管新生因子 / 妊娠 / 妊娠高血圧症候群 / 早産 / 絨毛細胞

Research Abstract

Angiogenic modulator, such as sFlt1 produced by poorly invaded placenta, is known to be involved in the pathogenesis of preeclampsia. This study demonstrated that 1) thrombin, a major factor produced during the clot formation, induced sFlt1 production in trophoblasts, and 2) measuring serum sFlt1 and placental growth factor (PlGF) can predict the onset of preeclampsia.

Research Products

• [Journal Article] Galectin-7 serum levels are altered prior to the onset of pre-eclampsia (2014)
  • Author(s): Menkhorst E, Koga K, Van Sinderen M, Dimitriadis E
  • Journal Title: Placenta Volume: 35(4) Pages: 281-5
• [Journal Article] Individualized management of umbilical endometriosis: a report of seven cases (2014)
  • Author(s): Saito A, Koga K, Osuga Y, Harada M, Takemura Y, Yoshimura K, Yano T, Kozuma S
  • Journal Title: J Obstet Gynaecol Res Volume: 40 Issue: 1 Pages: 40-5
  • DOI: 10.1111/jog.12118
  • Peer Reviewed
• [Journal Article] Toll-like Receptors at the Maternal-Fetal Interface in Normal Pregnancy and Pregnancy Complications (2014)
  • Author(s): Koga K1, Izumi G, Mor G, Fujii T, Osuga Y
  • Journal Title: Am J Reprod Immunol. Volume: in press Issue: 2 Pages: 192-205
  • DOI: 10.1111/aji.12258
  • Peer Reviewed
• [Journal Article] Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinase-1 in human uterine smooth muscle cells. (2013)
  • Author(s): Zhao Y1, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Fujii T, Kozuma S.
  • Journal Title: Am J Reprod Immunol. Volume: 69 Issue: 3 Pages: 240-7
  • DOI: 10.1111/aji.12061
  • Peer Reviewed
• [Journal Article] Laparoscopic ovarian-sparing surgery for a young woman with an exophytic ovarian fibroma (2013)
  • Author(s): Hasegawa A1, Koga K, Asada K, Wada-Hiraike O, Osuga Y, Kozuma S.
  • Journal Title: J Obstet Gynaecol Res. Volume: 39 Issue: 12 Pages: 1610-3
  • DOI: 10.1111/jog.12107
  • Peer Reviewed
• [Journal Article] Factors that predict poor clinical course among patients hospitalized with pelvic inflammatory disease (2013)
  • Author(s): Terao M, Koga K, Fujimoto A, Wada-Hiraike O, Osuga Y, Yano T, Kozuma S
  • Journal Title: J Obstet Gynaecol Res Volume: (Epub ahead of print) Issue: 2 Pages: 495-500
  • DOI: 10.1111/jog.12189
  • Peer Reviewed
• [Journal Article] Cyclic Stretch Augments Production of Neutrophil Chemokines and Matrix Metalloproteinases-1 (MMP-1) from Human Decidual Cells, and the Production was Reduced by Progesterone. (2013)
  • Author(s): Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Inoue S, Fujii T, Kozuma S
  • Journal Title: Am J Reprod Immunol Volume: 69 Issue: 5 Pages: 454-462
  • DOI: 10.1111/aji.12092
  • Peer Reviewed
• [Journal Article] Recurrence of endometrioma after laparoscopic excision and its prevention by medical management. (2013)
  • Author(s): Koga K, Osuga Y, Takemura Y, Takamura M, Taketani Y.
  • Journal Title: Front Biosci Volume: 5 Pages: 676-83
  • Peer Reviewed
• [Journal Article] Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia (2012)
  • Author(s): Zhao Y, Koga K, Osuga Y, Nagai M, Izumi G, Takamura M, Harada M, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Fertil Steril Volume: 98(4) Pages: 917-21
• [Journal Article] Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia. (2012)
  • Author(s): Zhao Y, Koga K, Osuga Y, Nagai M, Izumi G, Takamura M, Harada M, Hirota Y, Yoshino O, Taketani Y
  • Journal Title: Fertil Steril Volume: 98 Issue: 4 Pages: 917-21
  • DOI: 10.1016/j.fertnstert.2012.06.038
  • Peer Reviewed
• [Journal Article] High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia (2011)
  • Author(s): Wang B, Koga K, Osuga Y, Hirata T, Saito A, Yoshino O, Hirota Y, Harada M, Takemura Y, Fujii T, Taketani Y
  • Journal Title: Am J Reprod Immunol Volume: 66(2) Pages: 143-8
• [Journal Article] Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts (2011)
  • Author(s): Wang B, Koga K, Osuga Y, Cardenas I, Izumi G, Takamura M, Hirata T, Yoshino O, Hirota Y, Harada M, Mor G, Taketani Y
  • Journal Title: Endocrinology Volume: 152 Issue: 12 Pages: 4984-92
  • DOI: 10.1210/en.2011-0278
  • Peer Reviewed
• [Journal Article] High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia. (2011)
  • Author(s): Wang B, Koga K, Osuga Y, Hirata T, Saito A, Yoshino O, Hirota Y, Harada M, Takemura Y, Fujii T, Taketani Y.
  • Journal Title: Am J Reprod Immunol Volume: 66 Issue: 2 Pages: 143-148
  • DOI: 10.1111/j.1600-0897.2010.00975.x
  • Peer Reviewed
• [Journal Article] Toll-like Receptors at the Maternal-Fetal Interface in Normal Pregnancy and Pregnancy Complications
  • Author(s): Koga K, Izumi G, Mor G, Fujii T, Osuga Y
  • Journal Title: Am J Reprod Immunol Volume: (in press)
• [Presentation] Angiogenic factors in Preeclampsia (2013)
  • Author(s): Kaori Koga
  • Organizer: Annual congress of International society for reproductive immunology
  • Place of Presentation: USA
  • Year and Date: 2013-05-01
• [Presentation] Prediction of PE study in Japan (2013)
  • Author(s): Kaori Koga
  • Organizer: 2nd Preeclampsia Early Adopters Meeting
  • Place of Presentation: Austria
  • Year and Date: 2013-04-01
• [Presentation] Angiogenic Factors in Preeclampsia (2013)
  • Author(s): Kaori Koga
  • Organizer: Annual congress of International society for reproductive immunology
  • Place of Presentation: Boston, USA
  • Invited
• [Presentation] Angiogenic factors in preeclampsia (2013)
  • Author(s): Kaori Koga, Yutaka Osuga and Shiro Kozuma
  • Organizer: American society of reproductive immunology
  • Place of Presentation: Boston, U.S.A
  • Invited
• [Presentation] トロンビンは絨毛外栄養膜細胞の可溶型Fms様チロシンキナーゼ1の産生を増加させる (2011)
  • Author(s): 永井美和子、甲賀かをり, ら
  • Organizer: 日本妊娠高血圧学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2011-12-01
• [Presentation] 妊娠高血圧症候群と血管新生抑制因子 (2011)
  • Author(s): 甲賀かをり
  • Organizer: 第19回日本胎盤学会学術集会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-09-01
• [Presentation] 成因としての血管新生因子 (2011)
  • Author(s): 甲賀かをり
  • Organizer: 第21回腎と妊娠研究会ワークショップ
  • Place of Presentation: 埼玉
  • Year and Date: 2011-03-01