| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Non-muscle myosin II (NMII) is known to regulate cell shapes through the contraction of actin filaments, major components of the cytoskeleton. In muscle cells, NMII is known to form a complex which alined alternately with actin filaments and to provide force by contracting this "sarcomere" structure. On the other hand, the mechanism for providing NMII-based contraction force in the epithelial cells is still unclear. In this research, we demonstrated that NMII localized to the apical cell junction in the inner ear sensory epithelia, forming sarcomeric structures with the apical actin ring to provide string-like contraction force to the apical surface of the cells.
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