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Analysis of structural changes in rat retinal layers by optical coherence tomography in glaucoma-related models

Research Project

Project/Area Number 23592557
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKanazawa University

Principal Investigator

HIGASHIDE TOMOMI  金沢大学, 大学病院, 講師 (20291370)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsラット / 網膜 / 光干渉断層計 / 緑内障
Research Abstract

We examined whether our optical coherence tomography (OCT) for rat eyes is useful for quantitative evaluation of structural changes in the retinal layers in a model with intravitreal injection of endothelin-1 (ET-1) and for evaluation of neuroprotective effects of drugs. We found that the minimum dose of ET-1 to cause retinal injuries was 20 pmol, and that the thickness of the inner retinal layer was well correlated with the retinal ganglion cell loss. We further examined the effects of topical tafluprost applied once daily on the retinal injuries by 20 pmol ET-1 in a double blinded manner. Topical tafluprost reduced the thinning of the retinal nerve fiber layer and the inner retinal layer by OCT and retinal ganglion cell loss. These results indicate that our OCT system is useful for evaluation of neuroprotective effects in rat glaucoma –related models.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] OCT evaluation of neuroprotective effects of tafluprost on retinal injury after intravitreal injection of endothelin-1 in the rat eye.2014

    • Author(s)
      Nagata A, Omachi K, Higashide T, Shirae S, Shimazaki A, Nakamura M, Ishida N, Sugiyama K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 55 Issue: 2 Pages: 1040-1047

    • DOI

      10.1167/iovs.13-13056

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma2014

    • Author(s)
      Kawaguchi C, Nakatani Y, Ohkubo S, Higashide T, (他2名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: 58 Issue: 2 Pages: 197-204

    • DOI

      10.1007/s10384-013-0293-1

    • NAID

      210000180148

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cataract and its removal on ganglion cell complex thickness and peripapillary retinal nerve fiber layer thickness measurements by fourier-domain optical coherence tomography2013

    • Author(s)
      Nakatani Y, Higashide T, (他3名)
    • Journal Title

      J Glaucoma

      Volume: 22 Issue: 6 Pages: 447-455

    • DOI

      10.1097/ijg.0b013e3182894a16

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation by imaging of superior segmental optic hypoplasia and normal-tension glaucoma with inferior visual field defects only2013

    • Author(s)
      Yamada M, Ohkubo S, Higashide T, (他3名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57 Issue: 1 Pages: 25-33

    • DOI

      10.1007/s10384-012-0200-1

    • NAID

      10031168351

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between optic disc ovality and horizontal disc tilt in normal young subjects2013

    • Author(s)
      Takasaki H, Higashide T, (他3名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57 Issue: 1 Pages: 34-40

    • DOI

      10.1007/s10384-012-0193-9

    • NAID

      10031168352

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between macular ganglion cell complex parameters and visual field parameters after tumor resection in chiasmal compression2012

    • Author(s)
      Ohkubo S, Higashide T, (他4名)
    • Journal Title

      Jpn J Ophthalmol

      Volume: 56 Issue: 1 Pages: 68-75

    • DOI

      10.1007/s10384-011-0093-4

    • NAID

      10030248441

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Effects of tafluprost on endothelin-1-induced retinal injury in the rat2013

    • Author(s)
      Nagata A, Oomachi K, Higashide T, (他5名)
    • Organizer
      ARVO 2013 Annual Meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2013-05-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットエンドセリン硝子体内投与モデルにおけるタフルプロストの神経保護効果の検討2012

    • Author(s)
      長田敦,大町勝美,東出朋巳,(他5名)
    • Organizer
      第23回日本緑内障学会
    • Place of Presentation
      金沢市
    • Year and Date
      2012-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] モデル動物評価法:小動物の生体眼底観察2012

    • Author(s)
      東出朋巳
    • Organizer
      第32回比較眼科学会年次大会
    • Place of Presentation
      名古屋市(教育講演)
    • Year and Date
      2012-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] モデル動物評価法:小動物の生体眼底観察2012

    • Author(s)
      東出朋巳
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京都(教育セミナー)
    • Year and Date
      2012-04-06
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットエンドセリン硝子体内投与による網膜各層の障害と網膜神経節細胞数との関連2011

    • Author(s)
      長田敦,大町勝美,東出朋巳,(他5名)
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2011-05-13
    • Related Report
      2013 Final Research Report
  • [Presentation] In-vivo evaluation of thickness changes of retinal layers and retinal ganglion cells after intravitreal injection of endothelin-1 in rat eye2011

    • Author(s)
      Nagata A,Omachi K,Higashide T, (他5名
    • Organizer
      World Glaucoma Congress
    • Place of Presentation
      Paris,France
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットエンドセリン硝子体内投与モデルにおけるタフルプロストの神経保護効果の検討

    • Author(s)
      長田 敦、大町勝美、東出朋巳ほか
    • Organizer
      第23回日本緑内障学会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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