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Comprhensive examination for serum autoantigens in endogenous uveitis patients

Research Project

Project/Area Number 23592602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

OHNO Shigeaki  北海道大学, -, 名誉教授 (50002382)

Co-Investigator(Kenkyū-buntansha) ISHIDA Susumu  北海道大学, 大学院研究科, 教授 (10245558)
NAMBA Kenichi  北海道大学, 大学病院, 講師 (70333599)
KITAICHI Nobuyoshi  北海道大学, 医学研究科, 客員准教授 (40431366)
MEGURO Akira  横浜市立大学, 医学研究科, 特任助教 (60508802)
Co-Investigator(Renkei-kenkyūsha) MIZUKI Nobuhisa  横浜市立大学, 医学研究科, 教授 (90336579)
SAWASAKI Tatsuya  愛媛大学, 無細胞生命科学工学研究 センター, 准教授 (50314969)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsぶどう膜炎 / ベーチェット病 / 原田病 / 自己抗体 / 内因性ぶどう膜炎 / 難治性内因性ぶどう膜炎 / 網羅的解析 / バイオインフォマティクス解析 / バイオマーカー
Research Abstract

In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.
Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.
We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (106 results)

All 2013 2012 2011

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (65 results) (of which Invited: 13 results) Book (3 results)

  • [Journal Article] Clinical features of human T lymphotropic virus type-1 associated uveitis in Hokkaido, Japan2013

    • Author(s)
      Kase S, Namba K, Kitaichi N, Iwata D, Ohno S, Ishida S
    • Journal Title

      Jpn J Ophthalmo

      Volume: Vol.57 Issue: 4 Pages: 379-384

    • DOI

      10.1007/s10384-013-0244-x

    • NAID

      10031189427

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease2013

    • Author(s)
      Meguro A, Mizuki N(他18名)
    • Journal Title

      Ann Rheum Dis

      Volume: 72(9) Issue: 9 Pages: 1510-1516

    • DOI

      10.1136/annrheumdis-2011-200288

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.2013

    • Author(s)
      Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S, Ishida S
    • Journal Title

      Int J Mol Sci

      Volume: 14 Issue: 1 Pages: 2175-2189

    • DOI

      10.3390/ijms14012175

    • NAID

      120005228266

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease.2013

    • Author(s)
      Mizuuchi K, Kitaichi N, Namba K, Horie Y, Ishida S, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57 Issue: 3 Pages: 245-251

    • DOI

      10.1007/s10384-012-0229-1

    • NAID

      10031176278

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis (TINU) syndrome.2013

    • Author(s)
      Takemoto Y, Namba K, Mizuuchi K, Ohno S, Ishida S.
    • Journal Title

      Eur J Ophthalmol

      Volume: 23 Issue: 2 Pages: 255-257

    • DOI

      10.5301/ejo.5000240

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of contamination in the American Type Culture Collection stock of human adenovirus type 8 by whole genome sequencing.2013

    • Author(s)
      Yamane S, Lee A, Hanaoka N, Gonzalez G, Kaneko H, Ishida S, Kitaichi N, Ohno S, Koyanagi K, Aoki K, Fujimoto T, Yawata N, Watanabe H.
    • Journal Title

      J Virol

      Volume: 87 Issue: 2 Pages: 1285-1286

    • DOI

      10.1128/jvi.02875-12

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of intraocular pressure using a modified 360-degree suture trabeculotomy technique in primary and secondary open-angle glaucoma: A pilot study2012

    • Author(s)
      Chin S, Nitta T, Shinmei Y, Aoyagi M, Nitta A, Ohno S, Ishida S, Yoshida K.
    • Journal Title

      J Glaucoma

      Volume: 21 Issue: 6 Pages: 401-407

    • DOI

      10.1097/ijg.0b013e318218240c

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population2012

    • Author(s)
      Horie Y, et al
    • Journal Title

      Rheumatology

      Volume: (印刷中) Issue: 6 Pages: 983-6

    • DOI

      10.1093/rheumatology/ker444

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab in a case of occlusive retinal vasculitis accompanied with syphilitic intraocular inflammation.2012

    • Author(s)
      Ishijima K, Namba K, Ohno S, Mochizuki K, Ishida S.
    • Journal Title

      Case Report Ophthalmol.

      Volume: 3 Issue: 3 Pages: 434-437

    • DOI

      10.1159/000346046

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between elevation of serum antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behçet’s disease with infliximab.2012

    • Author(s)
      Iwata D, Namba K, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 250 Issue: 7 Pages: 1081-1087

    • DOI

      10.1007/s00417-011-1908-1

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chickenpox chorioretinitis with retinal exudates and periphlebitis.2012

    • Author(s)
      Kitamei H, Namba K, Kitaichi N, Wakayama A, Ohno S, Ishida S.
    • Journal Title

      Case Report Ophthalmol.

      Volume: 3 Issue: 2 Pages: 180-184

    • DOI

      10.1159/000339128

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops2012

    • Author(s)
      Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S
    • Journal Title

      Mol Vis

      Volume: Vol.18 Pages: 455-464

    • NAID

      120005372293

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinaseβinhibitor in rats2012

    • Author(s)
      Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S
    • Journal Title

      Mol Vis

      Volume: Vol.18 Pages: 2586-2597

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease2012

    • Author(s)
      Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N
    • Journal Title

      Arch Ophthalmol

      Volume: Vol.130 Pages: 592-598

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Astaxanthin increases choroidal blood flow velocity.2012

    • Author(s)
      Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 250 Issue: 2 Pages: 239-245

    • DOI

      10.1007/s00417-011-1843-1

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients2012

    • Author(s)
      Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Mol Vis

      Volume: Vol. 18 Pages: 512-518

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles2012

    • Author(s)
      Ota M, Meguro A, Kawagoe T, Mizuki N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 11 Pages: 7109-15

    • DOI

      10.1167/iovs.12-10491

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops.2012

    • Author(s)
      Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 18 Pages: 455-464

    • NAID

      120005372293

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.2012

    • Author(s)
      Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 18 Pages: 2586-2597

    • NAID

      120005372294

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicenter study of infliximab for refractory uveoretinitis in Behcet disease.2012

    • Author(s)
      Okada AA, Goto H, Ohno S, Mochizuki M, Kitaichi N, Namba K, Keino H, Watanabe T, Ishibashi T, Ito T, Sonoda K, Nakai K, Ohguro N, Sugita S, Kezuka T, Kaburaki T, Takamoto M, Mizuki N.
    • Journal Title

      Arch Ophthalmol.

      Volume: 130 Pages: 592-598

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients.2012

    • Author(s)
      Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H, Okada E, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Yuasa T, Ohno S, Inoko H, Mizuki N.
    • Journal Title

      Mol Vis.

      Volume: 18 Pages: 512-518

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 白金-金コロイド標識抗体を用いたアデノウイルス迅速診断検査キットの評価2011

    • Author(s)
      北市伸義、明尾潔、熊埜御堂隆、三島宣彦、三宅瑞絵、大塚宏之、高橋弘毅、溝口晋弘、東真千子、日隈陸太郎、安里良隆、青木功喜、石田晋、大野重昭
    • Journal Title

      医学のあゆみ

      Volume: 237巻 Pages: 214-215

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toward an integrated human adenovirus designation system that utilizes molecular and serological data and serves both clinical and fundamental virology2011

    • Author(s)
      Aoki K, Benko M, Davison JA, Echavarria M, Erdman D D, Kitaichi N, Ohno S, 他24名
    • Journal Title

      J Viol

      Volume: Vol.85 Issue: 11 Pages: 5703-5704

    • DOI

      10.1128/jvi.00491-11

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features of adenoviral conjunctivitis at the early stage of infection2011

    • Author(s)
      Aoki K, Kaneko H, Kitaichi N, Ohguchi T, Tagawa Y, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: Vol. 55 Issue: 1 Pages: 11-15

    • DOI

      10.1007/s10384-010-0894-x

    • NAID

      10029020444

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of NLRP1 gene polymorphisms in Vogt-Koyanagi-Harada disease2011

    • Author(s)
      Horie Y, Saito W, Kitaichi N, Miura T, Ishida S, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Issue: 1 Pages: 57-61

    • DOI

      10.1007/s10384-010-0887-9

    • NAID

      10029020610

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Investigation of Association between TLR9 Gene Polymorphisms and VKH in Japanese Patients2011

    • Author(s)
      Ito Ryuta; Ota Masao; Meguro Akira, et al
    • Journal Title

      OCULAR IMMUNOLOGY AND INFLAMMATION

      Volume: 19:3 Issue: 3 Pages: 202-205

    • DOI

      10.3109/09273948.2011.553981

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan2011

    • Author(s)
      Jin XH, Aoki K, Kitaichi N, Ariga T, Ishida S, Ohno S
    • Journal Title

      Mol Vis

      Volume: Vol.17 Pages: 3121-3127

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of human adenovirus hexon antigen using carbon nanotube sensors2011

    • Author(s)
      Jin XH, Ishii A, Aoki K, Ishida S, Mukasa K, Ohno S
    • Journal Title

      J Virol Methods

      Volume: Vol.171 Issue: 2 Pages: 405-407

    • DOI

      10.1016/j.jviromet.2010.12.004

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recombination analysis of intermediate human adenovirus type 53 in Japan by complete genome sequence2011

    • Author(s)
      Hisatoshi Kaneko, Koki Aoki, Susumu Ishida, Shigeaki Ohno, Nobuyoshi Kitaichi, Hiroaki Ishiko, Tsuguto Fujimoto, Yoshifumi Ikeda, Masako Nakamura, Gabriel Gonzalez, Kanako O.Koyanagi, Hidemi Watanabe, Tatsuo Suzutani
    • Journal Title

      Journal of General Virology

      Volume: 92 Issue: 6 Pages: 1251-1259

    • DOI

      10.1099/vir.0.030361-0

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan2011

    • Author(s)
      Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S.
    • Journal Title

      Br J Ophthalmol

      Volume: 95 Issue: 1 Pages: 32-36

    • DOI

      10.1136/bjo.2009.178772

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diffuse infiltrating retinoblastoma invading subarachnoid space2011

    • Author(s)
      Kase S, Yoshida K, Suzuki S, Ohshima KI, Ohno S, Ishida S
    • Journal Title

      Clin Ophthalmol

      Volume: Vol. 5 Pages: 861-863

    • DOI

      10.2147/opth.s20913

    • NAID

      120005372299

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese2011

    • Author(s)
      Sada T, et al
    • Journal Title

      Human Immunology

      Volume: 72 Issue: 3 Pages: 269-272

    • DOI

      10.1016/j.humimm.2010.12.007

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population2011

    • Author(s)
      Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Mol Vis

      Volume: Vol. 17 Pages: 731-736

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Guideline for Allergic Conjunctival Diseases2011

    • Author(s)
      Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H
    • Journal Title

      Allergology International

      Volume: 60 Issue: 2 Pages: 191-203

    • DOI

      10.2332/allergolint.11-RAI-0335

    • NAID

      130004477096

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 白金-金コロイド標識抗体を用いたアデノウイルス迅速診断検査キットの評価2011

    • Author(s)
      北市伸義、明尾 潔、熊埜御堂隆、三島宣彦、三宅瑞絵、大塚宏之、高橋弘毅、溝口晋弘、東真千子、日隈陸太郎、安里良隆、青木功喜、石田 晋、大野重昭
    • Journal Title

      医学のあゆみ

      Volume: 237 Pages: 210-214

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features of adenoviral conjunctivitis at the early stage of infection.2011

    • Author(s)
      Aoki K, Kaneko H, Kitaichi N, Ohguchi T, Tagawa Y, Ohno S
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Pages: 11-15

    • NAID

      10029020444

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan.2011

    • Author(s)
      Jin XH, Aoki K, Kitaichi N, Ariga T, Ishida S, Ohno S
    • Journal Title

      Mol Vis

      Volume: 17 Pages: 3121-3127

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.2011

    • Author(s)
      Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
    • Journal Title

      Mol Vis

      Volume: 17 Pages: 731-736

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical features of Vogt-Koyanagi-Harada's disease2013

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      7th Korean Uveitis Conference
    • Place of Presentation
      Seoul, Korea, Seoul National University
    • Year and Date
      2013-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Disease mechanisms and tretment of Behcet's disease2013

    • Author(s)
      Ohno S
    • Organizer
      14th Behcet's Disease
    • Place of Presentation
      Seoul, Korea, Seoul National University
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice.2013

    • Author(s)
      Kitaichi N, Lennikov A, Kase S, Noda K, Horie Y, Ohno S, Ishida S.
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Seattle, USA, Washington State Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Case of tuberculous endophthalmitis2013

    • Author(s)
      Hase K, Namba K, Saito W, Takemoto Y, Mizuuchi K, Ohno S, Ishida S.
    • Organizer
      International Workshop on Granulomatous Uveitis and Ocular Behcet's disease and Asia-Pacific Intraocular Inflammation Study Group
    • Place of Presentation
      Kaohsiung, Taiwan, Han-Hsien International Hotel
    • Related Report
      2013 Annual Research Report
  • [Presentation] Outcome of a modified 360-degree trabeculotomy for uveitic glaucoma with peripheral anterior synechiae2013

    • Author(s)
      Shinmei Y, Chin S, Yamamoto M, Nitta T, Namba K, Ohno S, Ishida S.
    • Organizer
      International Workshop on Granulomatous Uveitis and Ocular Behcet's disease and Asia-Pacific Intraocular Inflammation Study Group
    • Place of Presentation
      Kaohsiung, Taiwan, Han-Hsien International Hotel
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脈絡膜新生血管を合併しベバシズマブ硝子体注射を要した小児原田病の1例2013

    • Author(s)
      田川義晃、南場研一、齋藤 航、水内一臣、北市伸義、大野重昭、石田 晋
    • Organizer
      フォーサム2013大阪
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 周辺虹彩前癒着を伴うぶどう膜炎に続発した緑内障に対するsuture-trabeculotomyの成績2013

    • Author(s)
      大口剛司、新明康弘、新田卓也、山本麻梨亜、南場研一、大野重昭、陳 進輝、石田 晋
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ぶどう膜炎における網羅的糖差解析2013

    • Author(s)
      南場研一、北市伸義、安藤 亮、竹本裕子、水内一臣、堀江幸弘、大野重昭、天野麻穂、西村紳一郎、石田 晋
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ベーチェット病眼炎症発作とインフリキシマブトラフ値・サイトカイン血中濃度との相関2013

    • Author(s)
      水内一臣、竹本裕子、南場研一、宇野友絵、大野重昭、石田 晋
    • Organizer
      第117回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical features of Vogt-Koyanagi-Harada’s disease2013

    • Author(s)
      Ohno S, Namba K, Kitaichi N.
    • Organizer
      7th Korean Uveitis Conference
    • Place of Presentation
      Seoul, Korea, Seoul National University
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Disease mechanisms and tretment of Behcet’s disease2013

    • Author(s)
      Ohno S
    • Organizer
      14th Behcet’s Disease
    • Place of Presentation
      Seoul, Korea, Seoul National University
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Management dilemmas in uveitis2012

    • Author(s)
      Ohno S, Chin S
    • Organizer
      Second Biennial National Conference
    • Place of Presentation
      Bangladesh Uvea Society, Dhaka, Bang ladesh
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Presentation perspectives in Vogt-Koyanagi-Harada disease2012

    • Author(s)
      Ohno S
    • Organizer
      Second Biennial National Conference
    • Place of Presentation
      Bangladesh Uvea Society, Dhaka, Bangladesh
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Corticosteroid therapy in uveitis2012

    • Author(s)
      Ohno S
    • Organizer
      Ophthalmology Seminar
    • Place of Presentation
      Thimpu National Referral Hospital, Thimpu, Bhutan
    • Year and Date
      2012-12-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Management of second ry glaucoma in uveitis2012

    • Author(s)
      Ohno S, Chin S
    • Organizer
      Ophthalmology Seminar
    • Place of Presentation
      Thimpu National Referral Hospital : Thimpu, Bhutan
    • Year and Date
      2012-12-12
    • Related Report
      2013 Final Research Report
  • [Presentation] From autoimmunity to autoinf lammation in the immunopathogenesis of Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      2012 Seoul National University-Hokkaido University Joint Symposium in Ophthalmology
    • Place of Presentation
      Sapporo(Hokkaido University), Japan
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Epidemiology and genetics of Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      Bechet's Disease Symposium; How to differentiate Behcet's disease from other types of uveitis
    • Place of Presentation
      Sani(Sani Beach Resort), Greece
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Silk route disease : epidemio logy and genetics2012

    • Author(s)
      Ohno S
    • Organizer
      International meeting of collaborative studies on Behcet's disease and other uveitis entities
    • Place of Presentation
      Rome(ローマ大学), Italy
    • Year and Date
      2012-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti-TNFαtherapy for intractable uveoreti nitis in Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      Yokohama(パシフィコ横浜), Japan
    • Year and Date
      2012-07-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Diagnosis and treatment of a llergic conjuctivitis2012

    • Author(s)
      Ohno S
    • Organizer
      16th Afro Asian Congress of Ophthal mology
    • Place of Presentation
      Istanabul(HARBIYE MILITARY MUSEUM), Turkey
    • Year and Date
      2012-06-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Ocular lesions in Behcet's disease2012

    • Author(s)
      Ohno S
    • Organizer
      16th Afro Asian Congress of Ophthalmology
    • Place of Presentation
      Istanabul(HARBIYE MILITARY MUSEUM), Turkey
    • Year and Date
      2012-06-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Epidemiology of allergic con junctival diseases in Japan2012

    • Author(s)
      Ohno S
    • Organizer
      1st Conference on the Tear Film and Ocular Surface in Asia
    • Place of Presentation
      Kamakura(Kenchoji), Japan
    • Year and Date
      2012-04-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Amelioration of endotoxin-induced uveitis treated with an IkappaB kinase beta inhibitor2012

    • Author(s)
      Kitaichi N, Lennikov A, Namba K, Noda K, Kanda A, Ando R, Dong Z, Fukuhara J, Kinoshita S, Ohno S, Ishida S.
    • Organizer
      8th International Symposium on Uveitis
    • Place of Presentation
      Sani(Sani Beach Resort), Greece
    • Related Report
      2012 Research-status Report
  • [Presentation] Amelioration of experimental autoimmune uveoretinitis by inhibiton of Glyceraldehide-derived AGEs formation2012

    • Author(s)
      Kitaichi N, Dong Z, Iwata D, Takeuchi M, Namba K, Noda K, Kanda A, Iwabuchi K, Yamagishi S, Ohno S, Ishida S.
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      パシフィコ横浜、 Yokohama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Amelioration of endotoxin-induced uveitis treated with IMD-0354, an IkappaB inhibitor2012

    • Author(s)
      Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Namba K, Ohno S, Ishida S.
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      パシフィコ横浜、 Yokohama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Correlation between development of antinuclear antibody titre and decreased therapeutic efficacy in the treatment of Behçet’s disease with infliximab2012

    • Author(s)
      Namba K, Iwata D, Mizuuchi K, Kitaichi N, Kase S, Takemoto Y, Ohno S, Ishida S.
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      パシフィコ横浜、 Yokohama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of Infliximab Therapy in Behcet's disease2012

    • Author(s)
      Takemoto Y, Namba K, Kitaichi N, Mizuuchi K, Ohno S,
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      パシフィコ横浜、 Yokohama, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis in Japan2012

    • Author(s)
      Kitaichi N, Aoki K, Jin XH, Kaneko H, Gonzalez G, Yawata N, Koyanagi KO, Watanabe H, Ishida S, Ohno S.
    • Organizer
      10th International Adenovirus Meeting
    • Place of Presentation
      Umea University, Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] Epidemic keratoconjunctivitis (EKC) caused by human adenovirus in Hungary2012

    • Author(s)
      Pantó L, Gonzalez G, Koyanagi KO, Pankovics P, Reuter G, Kitaichi N, Ishida S, Ohno S, Aoki K, Watanabe H.
    • Organizer
      10th International Adenovirus Meeting
    • Place of Presentation
      Umea University, Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] Serum and salivary levels of bioactive antimicrobial peptide LL-37 in Behçet's disease and other ocular inflammatory diseases2012

    • Author(s)
      Isogai E, Kuroda K, Seki S, Kitaichi N, Namba K, Ohno S, Yoneyama H, Isogi H.
    • Organizer
      3rd International Symposium on Antimicrobial Peptides
    • Place of Presentation
      Lille(Villeneuve d'Ascq), France
    • Related Report
      2012 Research-status Report
  • [Presentation] Amelioration of experimental autoimmune uveoretinitis by inhibiton of toxic AGEs formation2012

    • Author(s)
      Dong Z, Kitaichi N, Iwata D, Ando R, Fukuhara J, Lennikov A, Kanda A, Noda K, Ohno S, Ishida S.
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Greater Fort Lauderdale/Broward County convention Center, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Amelioration of endotoxin-induced uveitis treated with an IKB kinase inhibitor, IMD-0354 in rats2012

    • Author(s)
      Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Namba K, Ohno S, Ishida S.
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Greater Fort Lauderdale/Broward County convention Center, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Management dilemmas in uveitis.2012

    • Author(s)
      Ohno S, Chin S.
    • Organizer
      Second Biennial National Conference,
    • Place of Presentation
      Bangladesh Uvea Society:Dhaka, Bangladesh
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Presentation perspectives in Vogt-Koyanagi-Harada disease.2012

    • Author(s)
      Ohno S.
    • Organizer
      Second Biennial National Conference,
    • Place of Presentation
      Bangladesh Uvea Society:Dhaka, Bangladesh
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Corticosteroid therapy in uveitis.2012

    • Author(s)
      Ohno S.
    • Organizer
      Ophthalmology Seminar
    • Place of Presentation
      Thimpu National Referral Hospital: Thimpu, Bhutan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Management of secondry glaucoma in uveitis.2012

    • Author(s)
      Ohno S, Chin S.
    • Organizer
      Ophthalmology Seminar
    • Place of Presentation
      Thimpu National Referral Hospital: Thimpu, Bhutan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] From autoimmunity to autoinflammation in the immunopathogenesis of Behcet's disease.2012

    • Author(s)
      Ohno S.
    • Organizer
      2012 Seoul National University-Hokkaido University Joint Symposium in Ophthalmology
    • Place of Presentation
      Sapporo(Hokkaido University), Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Epidemiology and genetics of Behcet's disease.2012

    • Author(s)
      Ohno S.
    • Organizer
      Bechet’s Disease Symposium; How to differentiate Behcet's disease from other types of uveitis.
    • Place of Presentation
      Sani(Sani Beach Resort), Greece
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Silk route disease: epidemiology and genetics.2012

    • Author(s)
      Ohno S.
    • Organizer
      International meeting of collaborative studies on Behcet’s disease and other uveitis entities
    • Place of Presentation
      Rome(ローマ大学), Italy
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Anti-TNFα therapy for intractable uveoretinitis in Behcet's disease.2012

    • Author(s)
      Ohno S.
    • Organizer
      15th International Conference on Behcet's Disease
    • Place of Presentation
      Yokohama(パシフィコ横浜), Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Diagnosis and treatment of allergic conjuctivitis.2012

    • Author(s)
      Ohno S.
    • Organizer
      16th Afro Asian Congress of Ophthalmology
    • Place of Presentation
      Istanabul(HARBIYE MILITARY MUSEUM), Turkey
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Ocular lesions in Behcet’s disease.2012

    • Author(s)
      Ohno S.
    • Organizer
      16th Afro Asian Congress of Ophthalmology
    • Place of Presentation
      Istanabul(HARBIYE MILITARY MUSEUM), Turkey
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Epidemiology of allergic conjunctival diseases in Japan.2012

    • Author(s)
      Ohno S.
    • Organizer
      1st Conference on the Tear Film and Ocular Surface in Asia:
    • Place of Presentation
      Kamakura(Kenchoji), Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Treatment of Behcet's disease with infliximab.3rd Japan-Korea Symposium on Behcet's Disease2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Mizuki N
    • Organizer
      Behcet's Disease Study Group, Ministry of Health. Labour and Welfare, Japan
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Infliximab therapy of Behcet's disease2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Mizuki N
    • Organizer
      3rd International Uveitis Symposium
    • Place of Presentation
      重慶カールトンホテル(中国)
    • Year and Date
      2011-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular genetics of uveitis2011

    • Author(s)
      Ohno S, Mizuki N
    • Organizer
      International Symposium on Recent Trends in Uveitis
    • Place of Presentation
      LV Prasad Eye Institue (India)
    • Year and Date
      2011-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Corticosteroid therapy of uveitis and intraocular inflammation2011

    • Author(s)
      Ohno S, Namba K
    • Organizer
      International Symposium on Recent Trends in Uveitis
    • Place of Presentation
      LV Prasad Eye Institue (India)
    • Year and Date
      2011-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Epidemiology of Behcet's disease. Session; Behcet's Disease : An Update and Future Prospects2011

    • Author(s)
      Ohno S, Kitaichi N, Meguro A, Mizuki N, Isogai E
    • Organizer
      11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Update of anti-TNF alpha therapy in Behcet's disease2011

    • Author(s)
      Ohno S, Namba K, Iwata D, Kitaichi N, Mizuki N
    • Organizer
      Italian Society of Uveitis and Inflammatory Ocular Diseases, (SIUMIO) / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Introduction, Conclusions and Future, Workshop on Epidemiology and Diagnosis of Behcet's Disease2011

    • Author(s)
      Ohno S
    • Organizer
      First Workshop of (IOBDSG) / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Panel Discussion with Chee SP, Goto H, Rao NA, Future studies and conclusions2011

    • Author(s)
      Ohno S, Panel Discussion with Chee SP, Goto H, Rao NA
    • Organizer
      The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Trabecular depigmentation in convalescent stage of VKH disease2011

    • Author(s)
      Ohno S, Mizuuchi K, Namba K, Kitaichi N, Horie Y
    • Organizer
      The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Classification and diagnostic criteria for Behcet's disease2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Managing ocular manifestations of systemic diseases with local therapy : Is it possible?2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      11th IOIS Congress and International Assembly of Ocular Inflammation Societies
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Year and Date
      2011-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Treatment of Behcet’s disease with infliximab.2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Mizuki N
    • Organizer
      3rd Japan-Korea Symposium on Behcet’s Disease, Behcet’s Disease Study Group, Ministry of Health. Labour and Welfare, Japan(招待講演)
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Research-status Report
  • [Presentation] Infliximab therapy of Behcet’s disease.2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N, Mizuki N
    • Organizer
      3rd International Uveitis Symposium.(招待講演)
    • Place of Presentation
      重慶カールトンホテル(中国)
    • Related Report
      2011 Research-status Report
  • [Presentation] Epidemiology of Behcet’s disease. Session; Behcet’s Disease : An Update and Future Prospects.2011

    • Author(s)
      Ohno S, Kitaichi N, Meguro A, Mizuki N, Isogai E
    • Organizer
      11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Update of anti-TNF alpha therapy in Behcet’s disease.2011

    • Author(s)
      Ohno S, Namba K, Iwata D, Kitaichi N, Mizuki N
    • Organizer
      Italian Society of Uveitis and Inflammatory Ocular Diseases (SIUMIO) / 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Introduction, Conclusions and Future. Workshop on Epidemiology and Diagnosis of Behcet's Disease.2011

    • Author(s)
      Ohno S
    • Organizer
      First Workshop of (IOBDSG) / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Panel Discussion with Chee SP, Goto H, Rao NA, Future studies and conclusions.2011

    • Author(s)
      Ohno S
    • Organizer
      The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Trabecular depigmentation in convalescent stage of VKH disease.2011

    • Author(s)
      Ohno S, Mizuuchi K, Namba K, Kitaichi N, Horie Y
    • Organizer
      The 7th International Workshop of Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia / 11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Classification and diagnostic criteria for Behcet’s disease.2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Managing ocular manifestations of systemic diseases with local therapy: Is it possible?2011

    • Author(s)
      Ohno S, Namba K, Kitaichi N
    • Organizer
      11th IOIS Congress and International Assembly of Ocular Inflammation Societies(招待講演)
    • Place of Presentation
      Hotel Taj Exotica (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Molecular genetics of uveitis.2011

    • Author(s)
      Ohno S, Mizuki N
    • Organizer
      International Symposium on Recent Trends in Uveitis(招待講演)
    • Place of Presentation
      LV Prasad Eye Institue (India)
    • Related Report
      2011 Research-status Report
  • [Presentation] Corticosteroid therapy of uveitis and intraocular inflammation.2011

    • Author(s)
      Ohno S, Namba K
    • Organizer
      International Symposium on Recent Trends in Uveitis(招待講演)
    • Place of Presentation
      LV Prasad Eye Institue (India)
    • Related Report
      2011 Research-status Report
  • [Book] 小児感染症学2011

    • Author(s)
      北市伸義, 大野重昭
    • Total Pages
      396
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 治療薬ハンドブック20112011

    • Author(s)
      北市伸義, 大野重昭
    • Total Pages
      1427
    • Publisher
      じほう
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Book] 小児感染症学2011

    • Author(s)
      北市伸義, 大野重昭.
    • Total Pages
      396
    • Publisher
      診断と治療社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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