Neuroprotection of experimental autoimmune optic neuritis by retinoid
Project/Area Number |
23592615
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Kyorin University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 視神経炎 / レチノイド / 自己免疫 |
Research Abstract |
In the present study, we investigated whether all trans-retinoic acid (ATRA) can reduce the degree of experimental autoimmune optic neuritis (EAON) in mice. Optic neuritis was induced in C57BL/6 mice by immunizing them with myelin oligodendrocyte glycoprotein35-55. ATRA (350 ug/mouse/time point) was administered every other day from day 0 to day 20. ATRA treatment significantly reduced the clinical score of EAE and the severity of the optic neuritis by histopathological analysis. The production of IFN-g and IL-17 by draining lymph node cells was significantly reduced in ATRA-treated mice. The degree of demyelination in the optic nerve of mice with EAE was significantly reduced after ATRA treatment. These findings demonstrate that ATRA treatment was able to reduce the severity of optic neuritis in mice with EAE.
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Report
(4 results)
Research Products
(51 results)