Tracheoplasty by combined growth factor and injectable cell therapy

• Project/Area Number: 23592625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Saitama Medical University (2012-2013); The University of Tokyo (2011)
• Principal Investigator: KOMURA Makoto 埼玉医科大学, 医学部, 教授 (10422289)
• Co-Investigator(Kenkyū-buntansha): TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371) ; IWANAKA Tadashi 東京大学, 医学部附属病院, 教授 (90193755) ; 星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 再生医療 / 気道再建 / 成長因子 / 軟骨再生 / b-FGF / 徐放化製剤

Research Abstract

A gelatin sponge with slowly releasing basic fibroblast growth factor (b-FGF) enhances chondrogenesis. This study investigated the optimal amount of basic fibroblast growth factor (b-FGF) in gelatin sponges to fabricate engineered cartilage. Gelatin sponges impregnated with more than 100micrpg/ml b-FGF incorporating beta-TCP with chondrocytes (10x10e6cells/ml) can fabricate engineered cartilage at 4 weeks after implantation. We devised a new tracheoplasty using a cartilage graft engineered outside the esophagus. This study investigated the feasibility of fabricating cartilage engineered outside the esophagus and using it to perform tracheoplasty in a rabbit model. Tracheoplasty with cartilage engineered outside the esophagus may be useful for developing reconstructed airways.

Research Products

• [Presentation] Tracheoplasty with cartilage engineered outside the esophagus (2014)
  • Author(s): Makoto Komura, Keisuke Suzuki, Ryousuke Satake, Tetsuro Kodaka, Kan Terawaki, Hiroaki Komuro, Tadashi Iwanaka
  • Organizer: PAPS2014 Banff
  • Place of Presentation: Canada
• [Presentation] 気管狭窄症に対する低侵襲術式開発のための食道壁軟骨再生の為の研究 (2014)
  • Author(s): 古村眞,古村浩子,大谷裕之,石丸哲也,小西健一郎,岩中督,星和人,高戸毅,田畑泰彦
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都
• [Presentation] 塩基性線維芽細胞増殖因子(b-FGF)の徐放化による軟骨再生過程の検討 (2014)
  • Author(s): 古村眞,古村浩子,大谷裕之,星和人,高戸毅,田畑泰彦,岩中督
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都
• [Presentation] ゼラチン多孔体による軟骨再生の為の塩基性線維芽細胞増殖因子(b-FGF)徐放量の検討 (2013)
  • Author(s): 古村浩子, 大谷裕之, 古村眞, 小室広昭, 田畑泰彦, 岩中督
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] Tracheoplasty with cartilage engineered outside the esophagus
  • Author(s): Komura Makoto
  • Organizer: PAPS2014
  • Place of Presentation: Canada
• [Presentation] 塩基性線維芽細胞増殖因子(b-FGF)の徐放化による軟骨再生過程の検討
  • Author(s): 古村 眞
  • Organizer: 第13回再生医療学会
  • Place of Presentation: 京都
• [Presentation] Optimal mount of basic fibroblast growth factor with gelatin sponges
  • Author(s): Makoto Komura ,Hiroko Komura, Yushi Otani, Yasuhiko Tabata
  • Organizer: 2nd Biotechnology World Congress
  • Place of Presentation: Dubai UAE
• [Presentation] ゼラチン多孔体による軟骨再生の為の塩基性線維芽細胞増殖因子（b‐FGF）徐放量の検討
  • Author(s): 古村浩子 大谷祐之 古村眞 小室広昭 田畑泰彦 岩中督
  • Organizer: 第12回再生医療学会
  • Place of Presentation: 横浜