Tracheoplasty by combined growth factor and injectable cell therapy
| Project/Area Number |
23592625
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Saitama Medical University (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
KOMURA Makoto 埼玉医科大学, 医学部, 教授 (10422289)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
IWANAKA Tadashi 東京大学, 医学部附属病院, 教授 (90193755)
星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医療 / 気道再建 / 成長因子 / 軟骨再生 / b-FGF / 徐放化製剤 |
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| Research Abstract |
A gelatin sponge with slowly releasing basic fibroblast growth factor (b-FGF) enhances chondrogenesis. This study investigated the optimal amount of basic fibroblast growth factor (b-FGF) in gelatin sponges to fabricate engineered cartilage. Gelatin sponges impregnated with more than 100micrpg/ml b-FGF incorporating beta-TCP with chondrocytes (10x10e6cells/ml) can fabricate engineered cartilage at 4 weeks after implantation. We devised a new tracheoplasty using a cartilage graft engineered outside the esophagus. This study investigated the feasibility of fabricating cartilage engineered outside the esophagus and using it to perform tracheoplasty in a rabbit model. Tracheoplasty with cartilage engineered outside the esophagus may be useful for developing reconstructed airways.
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Report
(4 results)
Research Products
(8 results)
