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Effects of butyric acid producing bacteria on epigenetic gene regulation and systemic diseases

Research Project

Project/Area Number 23592714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionNihon University

Principal Investigator

OCHIAI Kuniyasu  日本大学, 歯学部, 教授 (50095444)

Co-Investigator(Kenkyū-buntansha) IMAI Kenichi  日本大学, 歯学部, 准教授 (60381810)
TAMURA Muneaki  日本大学, 歯学部, 助教 (30227293)
TSUDA Hiromasa  日本大学, 歯学部, 助教 (60325470)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords酪酸 / エピジェネティクス / EBV / 酸化ストレス / HDAC / ウイルス / 微生物間相互作用 / 歯周病 / 短鎖脂肪酸 / n-酪酸 / エピジェネティク制御 / HIV / 腸内細菌叢 / 膣内細菌
Research Abstract

The EBV BZLF1 gene product ZEBRA is a master regulator of the transition from latency to the lytic replication cycle. We found that P. gingivalis induced expression of ZEBRA. This activity was associated with supernatant from bacterial culture. We demonstrated that culture supernatant from P. gingivalis, which contained high concentrations of butyric acid, inhibited HDACs, thus increasing histone acetylation and the transcriptional activity of the BZLF1 gene. These findings suggests that periodontal disease is a risk factor for EBV reactivation in infected individuals. In addition, we determined the effects of butyric acid retention in the gingival tissues on oxidative stress induction in the jugular blood mitochondria. We found that BA injected in the rat gingival tissue has prolonged retention in gingival tissues and H2O2 and CAT levels all increased after BA injection. This would insinuate that mitochondrial oxidative stress was induced ascribable to BA.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (78 results)

All 2014 2013 2012 2011 Other

All Journal Article (30 results) (of which Peer Reviewed: 28 results,  Open Access: 1 results) Presentation (42 results) (of which Invited: 3 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease.2014

    • Author(s)
      Cueno ME, Imai K, Tamura M, Ochiai K
    • Journal Title

      Cell Stress Chaperon

      Volume: 19 Issue: 2 Pages: 295-298

    • DOI

      10.1007/s12192-013-0462-7

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells2013

    • Author(s)
      Tsuda H,Zhao N,Imai K,Ochiai K,Yang P,Suzuki N
    • Journal Title

      Bosn J Basic Med Sci

      Volume: vol.13 Pages: 271-275

    • URL

      http://www.bjbms.org/archives/2013-4/11-Tsuda.pdf#search

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orally supplemented catechin increases heme amounts and catalase activities in rat heart blood mitochondoria: A comparison between middle-aged and young rats2013

    • Author(s)
      Cueno ME, Tamura M, Imai K, Ochiai K
    • Journal Title

      Experimental Gerontology

      Volume: 48 Issue: 11 Pages: 1319-1322

    • DOI

      10.1016/j.exger.2013.08.014

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overlapping glycosylation sequon influences the glycosylation pattern of a chimeric protein expressed in tomato leaf and callus2013

    • Author(s)
      Cueno ME, Imai K, Okamoto T, Ochiai K
    • Journal Title

      J Biotechnol

      Volume: 164 Issue: 1 Pages: 9-12

    • DOI

      10.1016/j.jbiotec.2012.12.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of microbial coinfection with HIV-1 and butyric acid-producing anaerobic bacteria on AIDS progression2013

    • Author(s)
      Imai K,Ochiai K
    • Journal Title

      J 0ral Biosci

      Volume: vol.55 Issue: 2 Pages: 55-60

    • DOI

      10.1016/j.job.2013.03.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Butyric acid retension in gingival tissue induces oxidative stress in jugular blood mitochondria2013

    • Author(s)
      Marni E. Cueno
    • Journal Title

      Cell Stress and Chaperones

      Volume: 18 Issue: 5 Pages: 661-665

    • DOI

      10.1007/s12192-013-0409-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher prevalence of Epstein-Barr virus DNA in deeper periodontal pockets of chronic periodontitis in Japanese patients2013

    • Author(s)
      Kato A, Imai K, Ochiai K, Ogata Y
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 8 Pages: 1-5

    • DOI

      10.1371/journal.pone.0071990

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells2013

    • Author(s)
      Tsuda H, Zhao N, Imai K, Ochiai K, Yang P, Suzuki N
    • Journal Title

      Bosn J Basic Med Sci

      Volume: 13 Pages: 271-275

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病原細菌の産生する短鎖脂肪酸と難治性全身疾患2013

    • Author(s)
      落合邦康
    • Journal Title

      静脈経腸栄養

      Volume: 28 Pages: 945-952

    • NAID

      130004487314

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病の潜伏感染ウイルスの再活性化とがん細胞転移への影響2013

    • Author(s)
      落合邦康
    • Journal Title

      日大医学雑誌

      Volume: 72 Pages: 178-179

    • NAID

      10031190212

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周疾患の発症と進展におけるウイルスの関与 第1回:歯周疾患の病因論におけるウイルスの意義.2013

    • Author(s)
      今井健一,落合邦康
    • Journal Title

      日本歯科評論

      Volume: 73 Pages: 151-153

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周疾患の発症と発展におけるウイルスの関与 第2回:根尖性歯周炎とヘルペスウイルス感染2013

    • Author(s)
      武市 収, 小木曽文内, 今井健一, 落合邦康
    • Journal Title

      日本歯科評論

      Volume: 73 Pages: 130-132

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周疾患の発症と進展におけるウイルスの関与 第3回:ウイルスと歯周病との関連2013

    • Author(s)
      小方頼昌, 加藤彩子, 今井健一, 落合邦康
    • Journal Title

      日本歯科評論

      Volume: 73 Pages: 143-145

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbial interaction between HIV-1 and anaerobic bacteria producing butyric acid: its potential implication in AIDS progression.2012

    • Author(s)
      Imai K et al.
    • Journal Title

      Future virology

      Volume: 7(10) Issue: 10 Pages: 1005-1014

    • DOI

      10.2217/fvl.12.92

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria.2012

    • Author(s)
      Imai K et al.
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: 69(15) Issue: 15 Pages: 2583-2592

    • DOI

      10.1007/s00018-012-0936-2

    • NAID

      10029976312

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exploring the possible application of catechin (gel) for oral care of the elderly and disabled individuals.2012

    • Author(s)
      Tamura M et al.
    • Journal Title

      JDSR

      Volume: 48 Issue: 2 Pages: 126-134

    • DOI

      10.1016/j.jdsr.2012.02.004

    • NAID

      10030957811

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytokinin dehydrogenase differentially regulates cytokinin and indirectly affects hydrogen peroxidase accumulation in tomato leaf.2012

    • Author(s)
      Cueno ME et al.
    • Journal Title

      J. plant. physi

      Volume: 169(8) Issue: 8 Pages: 834-838

    • DOI

      10.1016/j.jplph.2012.01.008

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microbial Interaction of Periodontopathic Bacterium Porphyromonas gingivalis and HIV -Possible Causal Link of Periodontal Diseases to AIDS Progression-2012

    • Author(s)
      Imai K et al.
    • Journal Title

      Current HIV Research

      Volume: 10 Issue: 3 Pages: 213-220

    • DOI

      10.2174/157016212800618183

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microbial interaction of periodontopathic bacteria and Epstein–Barr virus and their implication of periodontal diseases.2012

    • Author(s)
      Imai K et al.
    • Journal Title

      J. Oral Biosci.

      Volume: 54(3) Issue: 3 Pages: 164-168

    • DOI

      10.1016/j.job.2012.07.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「歯学的医学」の実践を目指して-.2012

    • Author(s)
      今井健一 他
    • Journal Title

      日本歯科評論

      Volume: 72(10) Pages: 9-11

    • Related Report
      2012 Research-status Report
  • [Journal Article] 新開発口腔ケア剤によるCandida albicans病原性の抑制効果とその機序の解明.2012

    • Author(s)
      田村宗明 他
    • Journal Title

      無菌生物 J Germfree Life gnotobiol

      Volume: 42 Pages: 85-90

    • NAID

      10031131377

    • Related Report
      2012 Research-status Report
  • [Journal Article] Microbial Interaction of Periodontopathic Bacterium Porphyromonas gingivalis and HIV -Possible Causal Link of Periodontal Diseases to AIDS Progression2011

    • Author(s)
      Imai K,Victriano AF,Ochiai K,Okamoto T
    • Journal Title

      J. 0ral Biosci

      Volume: vol.53(3) Issue: 3 Pages: 213-220

    • DOI

      10.1016/s1349-0079(11)80004-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression2011

    • Author(s)
      Ann Florence B
    • Journal Title

      Fed.Eur.Biochem.Soc.Lett

      Volume: 585 Issue: 7 Pages: 1103-1111

    • DOI

      10.1016/j.febslet.2011.03.017

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of histone modification on transcriptional regulation and HIV-1 gene expression: possible mechanisms of periodontal diseases in AIDS progression2011

    • Author(s)
      Imai K,Ochiai K
    • Journal Title

      Journal of Oral Science

      Volume: 53 Issue: 1 Pages: 1-13

    • DOI

      10.2334/josnusd.53.1

    • NAID

      130000659030

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression.2011

    • Author(s)
      Victoriano AF
    • Journal Title

      FEBS Lett.

      Volume: 585 Pages: 1103-1111

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of human cyclin T1 N-terminal region for human immunodeficiency virus-1 Tat transcriptional activation.2011

    • Author(s)
      Asamitsu K
    • Journal Title

      J Mol Biol.

      Volume: 410 Pages: 887-895

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Butyric acid effects in the development of periodontitis and systemic diseases.2011

    • Author(s)
      Ochiai K
    • Journal Title

      J Oral Biosci.

      Volume: 53 Pages: 213-220

    • NAID

      10029494848

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of histone modification on transcriptional regulation and HIV-1 gene expression: possible mechanisms of periodontal diseases in AIDS progression.2011

    • Author(s)
      Imai K
    • Journal Title

      J Oral Sci.

      Volume: 53 Pages: 1-13

    • NAID

      130000659030

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite不織布を用いたラット歯周病実験モデルの開発2011

    • Author(s)
      田村宗明
    • Journal Title

      日大歯学

      Volume: 85 Pages: 125-128

    • NAID

      10031146278

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 感染症における微生物間相互作用 -酪酸産生常在菌による潜伏感染HIV-1賦活化-2011

    • Author(s)
      今井健一
    • Journal Title

      無菌生物

      Volume: 41 Pages: 117-122

    • NAID

      10029976312

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Periodontal bacterial metabolite induces rat blood apoptotic and pyroptotic caspase activities2014

    • Author(s)
      Marni E. Cueno,Kuniyasu 0chiai
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] A possible correlation between oral butyric acid and aging2014

    • Author(s)
      落合邦康、Marni Cueno
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔細菌はインフルエンザウィルス感染を促進する2014

    • Author(s)
      神尾宜目、今井健一、田村宗明、Marni Cueno、粛藤夕子、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔細菌のウイルス感染症促進作用ーEBVおよびインフルエンザ感染に及ぼす影響ー2014

    • Author(s)
      今井健一、神尾宜目、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔細菌のウィルス感染症促進作用 -EBVおよびインフルエンザ感染に及ぼす影響-2014

    • Author(s)
      今井健一、神尾宜昌、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hemin濃度がPorphyromonas gingivalis増殖に及ぼす影響2014

    • Author(s)
      大屋学、田村宗明、Marni Cueno、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] A possible correlation between oral butyric acid and aging2014

    • Author(s)
      落合邦康、Marni Cueno
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Periodontal bacterial metabolite induces rat blood apoptotic and pyroptotic caspase activities2014

    • Author(s)
      Marni Cueno、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔細菌はインフルエンザウィルス感染を促進する2014

    • Author(s)
      神尾宜昌、今井健一、田村宗明、Marni Cueno、齋藤夕子、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structural significance of the beta1k396 residue found in the Porphyromonas gingivalis sialidase2014

    • Author(s)
      齋藤夕子、Marni Cueno、神尾宜昌、今井健一、田村宗明、落合邦康
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周病を誘因とする全身疾患2013

    • Author(s)
      落合邦康
    • Organizer
      第17回日本腸内細菌学会
    • Place of Presentation
      北里大学コンベンションホール,東京
    • Year and Date
      2013-06-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病原細菌代謝産物・酪酸の歯周組織に及ぼす影響と潜伏感染ウイルスの再活性化2013

    • Author(s)
      落合邦康、今井健一、落合智子
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ国際会議場、千葉
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] P. gingivalis EBV相互作用による潜伏感染EBVの再活性化と病態への関与.2013

    • Author(s)
      今井健一 他
    • Organizer
      第86回 日本細菌学会総会
    • Place of Presentation
      幕張メッセ (千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] EBV-歯周病原細菌間相互作用による潜伏感染EBVの再活性化と病態への関与2012

    • Author(s)
      今井健一、落合邦康
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2012-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Influenza A H1N1 Pathogenesis And Transmissibility Are Structurally Correlated To The Salt Bridge Between The HA1 110-helix And HA2 B-loop2012

    • Author(s)
      Cueno,M.E. K. Imai,and K. 0chiai
    • Organizer
      Second isirv AVG conference
    • Place of Presentation
      Melia Hotel,Vietnam
    • Year and Date
      2012-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病原細菌による潜伏感感染EBVの再活性化と病態への関与2012

    • Author(s)
      落合邦康
    • Organizer
      第55回日本歯周病学会秋季学術大会
    • Place of Presentation
      つくば国際会議場、茨城
    • Year and Date
      2012-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗菌ジェルによる要介護者口腔微生物数のコントロール効果2012

    • Author(s)
      田村宗明、落合邦康
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      奥羽大学、福島
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Butyric acid-induced mitochondrial oxidative stress is correlated to HEME accumulation.2012

    • Author(s)
      Cueno, M.E 他
    • Organizer
      Keystone Symposia (S2): Aging and Diseases of Aging
    • Place of Presentation
      シェラトン都ホテル東京 (東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] BIX01294はRAW264.7細胞のRANKL誘導破骨細胞分化を抑制する2011

    • Author(s)
      津田啓方、今井健一、落合邦康、鈴木直人
    • Organizer
      第53回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      長良川国際会議場、岐阜
    • Year and Date
      2011-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Reactivation of latent HIV-1 infection by butyric acid-producing bacteria involves histone modification2011

    • Author(s)
      K Imai,M Tamura,K Yamada,T 0kamoto,K 0chiai
    • Organizer
      国際微生物学連合
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2011-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 歯周病を誘因とする全身疾患

    • Author(s)
      落合邦康
    • Organizer
      第17回日本腸内細菌学会
    • Place of Presentation
      北里大学コンベンションホール,東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯周病原細菌代謝産物・酪酸の歯周組織に及ぼす影響と潜伏感染ウイルスの再活性化

    • Author(s)
      落合邦康 他
    • Organizer
      第86回 日本細菌学会総会
    • Place of Presentation
      幕張メッセ (千葉)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] EBV-歯周病原細菌間相互作用による潜伏感染EBVの再活性化と病態への関与.

    • Author(s)
      今井健一 他
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] 口腔カンジダの病原性に対する抗菌ジェルの抑制効果と臨床応用.

    • Author(s)
      田村宗明 他
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] Influenza A H1N1 Pathogenesis And Transmissibility Are Structurally Correlated To The Salt Bridge Between The HA1 110-helix And HA2 B-loop

    • Author(s)
      Cueno, M.E 他
    • Organizer
      Second isirv AVG conference
    • Place of Presentation
      Melia Hotel (Vietnam)
    • Related Report
      2012 Research-status Report
  • [Presentation] 新たな視点から歯周病原菌に対するリスクマネージメントを考える-歯周病研究における嫌気性菌代謝産物の意義-

    • Author(s)
      落合邦康
    • Organizer
      第55回日本歯周病学会学術大会
    • Place of Presentation
      つくば国際会議場 (茨城)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 抗菌ジェルによる要介護者口腔微生物数のコントロール効果.

    • Author(s)
      田村宗明 他
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学 (福島)
    • Related Report
      2012 Research-status Report
  • [Presentation] 高齢者の口腔ケア用抗菌ジェルの臨床応用実用化に向けての検討.

    • Author(s)
      田村宗明 他
    • Organizer
      第17・18回日本摂食・嚥下リハビリテーション学会・共催学術大会
    • Place of Presentation
      札幌市教育文化会館 (北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] P.gingivalis-produced butryic acid: effects on periodontal tissue and reactivation of latently infected viruses

    • Author(s)
      落合邦康 他
    • Organizer
      First International Conference on Porphyromonas gingivalis and Related Bacterial Species.
    • Place of Presentation
      長崎大学 (長崎)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Microbial interaction of periodontopathic bacteria and Epstein Barr virus in periodontal diseases -Porphyromonas gingivalis induces the EBV lytic switch transactivator ZEBRA by histone modification-.

    • Author(s)
      今井健一 他
    • Organizer
      First International Conference on Porphyromonas gingivalis and Related Bacterial Species.
    • Place of Presentation
      長崎大学 (長崎)
    • Related Report
      2012 Research-status Report
  • [Presentation] Epidemiological significance of non-glycosylated Asn residues found in the hemagglutinin protein of the H1N1 influenza virus from 1918 to 2012.

    • Author(s)
      Cueno, M.E 他
    • Organizer
      15th International Congress on Infectious Diseases.
    • Place of Presentation
      Centara Grand & Bangkok Convention Centre at Central World (Thailand)
    • Related Report
      2012 Research-status Report
  • [Presentation] The Role of the Influenza Hemagglutinin Overlapping Glycosylation Sequon (Asn-Asj-Ser-Thr) In Antibody Escape and Glycoform Formation.

    • Author(s)
      Cueno M. E.
    • Organizer
      第40回日本本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Extracellular HIV-1 TAT(ExTat) Regulates Bacterial Superoxide Discutase (SOD) Allowing Upregulation of Reactive Oxygen Specied (ROS) in Porphorymonas gingivalis and Fusobacterium uncleatum

    • Author(s)
      Cueno M. E.
    • Organizer
      第17回国際無菌生物シンポジウム/第34回国際医学微生物生態学会合同会議
    • Place of Presentation
      ナビイオス横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] BIX01294はRAW264.7細胞のRANKL誘導破骨細胞分化を抑制する

    • Author(s)
      津田啓方
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 口腔扁平上皮癌進展に及ぼす酪酸の影響

    • Author(s)
      宮崎裕司
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 歯周病原菌の酸化ストレス応答に及ぼすHIV Tatの影響

    • Author(s)
      M. Cueno
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] ウィルス感染症における口腔細菌学の影響 -歯周病原菌による潜伏感染EBVの再活性化機構-

    • Author(s)
      今井健一
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Reactivation of latent HIV-1 infection by butyric acid-producing bacteria involves histone modification.

    • Author(s)
      Imai K.
    • Organizer
      国際微生物学連合
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Human immunodeficiency virus-1 Tat induces oxidative stress in tomato plants.

    • Author(s)
      Cueno M. E.
    • Organizer
      国際微生物学連合
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Aproposed Mechanism by which oxidative stress is induced by human immunodeficiency virus-1(HIV) TAT: Cellular Heme Accumulation.

    • Author(s)
      Cueno M. E.
    • Organizer
      アジアフリーラジカル学会・アジア&日本ミトコンドリア学会,5th SFRR-ASIA, 8th ASMRM, 11th J-MIT
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 口腔内細菌によるHPV の活性化および癌進展への関与

    • Author(s)
      宮崎裕司
    • Organizer
      第48回日本消化器免疫学会総会
    • Place of Presentation
      エクセルホテル東急(石川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] A plant-based approach towards understanding host-dependent variations in the Influenza A hemagglutinin

    • Author(s)
      Cueno M. E.
    • Organizer
      Keystone Symposium
    • Place of Presentation
      香港(中華人民共和国)
    • Related Report
      2011 Research-status Report
  • [Book] 腸内共生系のバイオサイエンス(財団法人日本ピフィズス菌センター編)2011

    • Author(s)
      落合邦康
    • Publisher
      丸善出版社株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 腸内共生系のバイオサイエンス(財団法人日本ビフィズス菌センター編)2011

    • Author(s)
      落合邦康
    • Publisher
      丸善出版社株式会社
    • Related Report
      2011 Research-status Report
  • [Book] 化学療法の領域 「 序 口腔感染症の意味論 -口腔内細菌による全身疾患と口腔ケア-」2011

    • Author(s)
      落合邦康
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Research-status Report
  • [Book] 化学療法の領域 「口腔内細菌とウイルス感染症 -歯周病原菌によるエピジェネティック制御を介する潜伏HIVの再活性化機構-」2011

    • Author(s)
      今井健一
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Research-status Report
  • [Remarks] ホームページ

    • URL

      http://www2.dent.nihon-u.ac.jp/microbiology/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.nihon-u.ac.jp/bact/index.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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