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Human application of in vivo EPR Dosimetry

Research Project

Project/Area Number 23592769
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKagawa University

Principal Investigator

MIYAKE Minoru  香川大学, 医学部, 准教授 (20239370)

Co-Investigator(Kenkyū-buntansha) MATSUI Yoshiro  香川大学, 医学部歯科口腔外科学講座, 教授 (10181687)
IWASAKI Akinori  香川大学, 医学部附属病院, 助教 (10437676)
YAMAGUCHI Ichiro  国立保健医療科学院, 上席主任研究官 (50311395)
KUNUGIDA Naoki  国立保健医療科学院, 部長 (90178020)
Co-Investigator(Renkei-kenkyūsha) HIRATA Hiroshi  北海道大学, 情報科学研究科, 教授 (60250958)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsEPR / Dosimetry / 被ばく線量測定 / 歯エナメル質 / Dosiemtry
Research Abstract

The measuring device for the radiation exposure dose in human teeth enamel using L-band in vivo Electron Paramagnetic Resonace (EPR) was newly developed. The loop-resonator designed for human upper central incisor were specially made, the S / N ratio with this new resonator, it was improved of 2.7 times that of the conventional apparatus. 95.0% sensitivity and 90.0% specificity in 1Gy irradiated specimen as the detection sensitivity were achieved. Further, the structure of the measuring setting was modified which can be measured in a sitting position, it can be reduced the measurement noise due to moving of the subjects. The measurement from 35 volunteers was performed, and the data of the background EPR signals in existing in enamel were obtained.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (18 results) Remarks (4 results)

  • [Journal Article] Four-channel surface coil array for 300-MHz pulsed EPR imaging : proof of concept experimets2014

    • Author(s)
      A. Enomoto, H.Hirata, S.Matsumoto, K. Sato, S. Subramanian, M.C. Krishna
    • Journal Title

      Magnetic Resonace in Medicine

      Volume: 71 Pages: 853-854

    • Related Report
      2013 Final Research Report
  • [Journal Article] Four-channel surface coil array for sequential CW-EPR imaging acquisition2013

    • Author(s)
      A.Enomoto, M.Enomoto, H.Fujii, H.Hirata
    • Journal Title

      J. Magnetic Resonance

      Volume: 234 Pages: 21-29

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four-channel surface coil array for sequential CW-EPR image acquisition2013

    • Author(s)
      A. Enomoto, M. Emoto, H. Fujii, H. Hirata
    • Journal Title

      Journal of Magnetic Resonance

      Volume: 234 Pages: 21-29

    • DOI

      10.1016/j.jmr.2013.06.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four-Channel Surface Coil Array for 300-MHz : Proof-of-concept experiments2013

    • Author(s)
      Ayano Enomoto, Hiroshi Hirata, Shingo Matsumoto, Keita Saito, Sankaran Subramanian, Murali C. Krishna, and Nallthamby Devasahayam
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: 71 Issue: 2 Pages: 853-854

    • DOI

      10.1002/mrm.24702

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo radiation dosimetry using L band EPR- The measurement from volunteers in FUKUSHIMA Prefecture, Japan2013

    • Author(s)
      M. Miyake, I.Yamaguchi , M.Umakoshi , H. Hirata, N.Kunugita, Y. Matsui, B. Williams, H. Swartz
    • Organizer
      The 41^<st> Meeting of the International Society on Oxygen Transport to Tissue and the International EPR Conference
    • Place of Presentation
      NH, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The detection of radiation induced radicals from teeth enamel by in vivo EPR ( Electron paramagnetic Resonance) Dosimetry2013

    • Author(s)
      M. Miyake, I.Yamaguchi , M.Umakoshi , H. Hirata , N.Kunugita, Y. Matsui, A.Iwasaki
    • Organizer
      J-RAPID Symposium
    • Place of Presentation
      Katahira Sakura Hall, Tohoku University, Katahira Campus,2-1-1, Katahira, Aoba-ku, Sendai 980-8577, JAPAN
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体EPRを用いた放射線被ばく線量測定-福島在住のボランティアからの計測2013

    • Author(s)
      三宅実、馬越通崇、山口一郎、岩崎昭憲、澤井史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体EPR (Electron Paramagnetic Resonance:電子常磁性体共鳴法)を用いた放射線被ばく線量測定ー福島在住のボランティアからの計測―2013

    • Author(s)
      三宅 実、馬越通崇、山口一郎、岩崎昭憲、澤井 史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] EPR(Electron Paramagnetic Resonance:電子常磁性共鳴法)線量推計に用いる口腔内新規共振器の感度評価2013

    • Author(s)
      馬越 通崇、三宅 実、岩崎 昭憲、澤井 史、三木 武寛、川畑 知広、今川 尚子、小川 尊明、大林 由美子、松井 義郎、平田 拓、山口 一郎
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] In-vivo radiation dosimetry using L band EPR- The measurement from volunteers in FUKUSHIMA Prefecture, Japan -2013

    • Author(s)
      Minoru Miyake, Ichiro Yamaguchi, Michitaka Umakoshi, Hiroshi Hirata, Naoki Kunugita, Yoshiro Matsui, Benjamin Williams and Harold Swartz
    • Organizer
      The 41st Meeting of the Internal Society on Oxygen Transport to Tissue and the International EPR Conference
    • Place of Presentation
      Dartmouth College, NH, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Radiation induced signal dependence on measurement position and enamel thickness forhuman incisor teeth2013

    • Author(s)
      Michitaka Umakoshi, Minoru Miyake, IchiroYamaguchi, Hiroshi Hirata, Naoki Kunugita, Yoshiro Matsui, Benjamin Williams, Harold Swartz
    • Organizer
      The 41st Meeting of the Internal Society on Oxygen Transport to Tissue and the International EPR Conference
    • Place of Presentation
      Dartmouth College, NH, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Preliminary Trial of Neuron Dosimetry of ExtractedTooth Using L-Band EPR2013

    • Author(s)
      Ichiro Yamagushi, Hitoshi Sato, Hiroshi Yoshii, Tsuyoshi Hamano
    • Organizer
      The 41st Meeting of the Internal Society on Oxygen Transport to Tissue and the International EPR Conference
    • Place of Presentation
      Dartmouth College, NH, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] The detection of radiation induced radicals from teeth enamel by in vivo EPR ( Electron paramagnetic Resonance) Dosimetry2013

    • Author(s)
      Minoru Miyake, Ichiro Yamaguchi , Michitaka Umakoshi , Hiroshi Hirata, Naoki Kunugita, Yoshiro Matsui , Akinori Iwasaki, Harold M. Swartz
    • Organizer
      J-RAPID Symposium
    • Place of Presentation
      Sendai , Miyagi, JAPAN
    • Related Report
      2012 Research-status Report
  • [Presentation] In-vivo radiation dosimetry using L band EPR - The measurement from volunteers in FUKUSHIMA Prefecture, Japan -2013

    • Author(s)
      Minoru Miyake, Ichiro Yamaguchi, Michitaka Umakoshi , Hiroshi Hirata, Naoki Kunugita, Yoshiro Matsui, Benjamin Williams and Harold Swartz
    • Organizer
      41st Annual ISOTT Meeting & EPR 2013
    • Place of Presentation
      NH, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Radiation induced signal dependence on measurement position and enamel thickness for human incisor teeth2013

    • Author(s)
      Michitaka Umakoshi, Minoru Miyake, IchiroYamaguchi, Hiroshi Hirata, Naoki Kunugita, Yoshiro Matsui , Benjamin Williams , Harold Swartz
    • Organizer
      41st Annual ISOTT Meeting & EPR 2013
    • Place of Presentation
      NH, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Preliminary Trial of neuron dosimetry of extracted tooth using L band EPR2013

    • Author(s)
      Ichiro Yamaguchi, Minoru Miyake, Michitaka Umakoshi, Hiroshi Hirata, Naoki Kunugita,Benjamin Williams and Harold Swartz
    • Organizer
      41st Annual ISOTT Meeting & EPR 2013
    • Place of Presentation
      NH, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体EPR (Electron Paramagnetic Resonance :電子常磁性体共鳴法)を用いた前歯からの被ばく線量測定2012

    • Author(s)
      三宅実、馬越通崇、岩崎昭憲、今川尚子、澤井史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎、山口一郎
    • Organizer
      第66回日本口腔科学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体EPR (Electron Paramagnetic Resonance:電子常磁性体共鳴法)を用いた前歯からの被ばく線量測定2012

    • Author(s)
      三宅 実、馬越通崇、岩崎昭憲、今川尚子、澤井 史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎、山口一郎
    • Organizer
      第66回日本口腔科学会総会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Preliminary results on in-vivo radiation dose dosimetry using L band EPR at NIPH - The research involving human subjects supported by J-RAPID has been started in JAPAN-2012

    • Author(s)
      Ichiro Yamaguchi, Minoru Miyake, Michitaka Umakoshi, Hiroshi Hirata, Naoki Kunugita, Yoshiro Matsui, Benjamin Williams and Harold Swartz
    • Organizer
      The 2nd International Symposium on Electron Spin Resonace
    • Place of Presentation
      Sendai , Miyagi, JAPAN
    • Related Report
      2012 Research-status Report
  • [Presentation] EPR Dosimetry for Response to a Large-scale Radiation Incident2012

    • Author(s)
      Ann Barry Flood, Hiroshi Hirata, Ichiro Yamaguchi, Minoru Miyake, Harold M. Swartz
    • Organizer
      The 2nd International Symposium on Electron Spin Resonace
    • Place of Presentation
      Sendai , Miyagi, JAPAN
    • Related Report
      2012 Research-status Report
  • [Presentation] EPR(Electron Paramagnetic Resonace :電子常磁性体共鳴法)を用いた生体被爆線量測定2011

    • Author(s)
      三宅実、山口一郎、岩崎昭憲、馬越通崇、今川尚子、澤井史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎
    • Organizer
      日本口腔科学会中国四国地方会
    • Place of Presentation
      松山市
    • Year and Date
      2011-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] EPR (Electron Paramagnetic Resonance:電子常磁性体共鳴法)を用いた生体被曝線量測定

    • Author(s)
      三宅 実、山口一郎、岩崎昭憲、馬越通崇、今川尚子、澤井 史、南佑子、三木武寛、小川尊明、大林由美子、松井義郎
    • Organizer
      日本口腔科学会中国四国地方会
    • Place of Presentation
      松山市、愛媛県
    • Related Report
      2011 Research-status Report
  • [Remarks] EPR線量測定研究結果

    • URL

      http://trustrad.sixcore.jp/invivo_EPR/

    • Related Report
      2013 Final Research Report
  • [Remarks] EPR線量測定研究結果

    • URL

      http://trustrad.sixcore.jp/invivo_EPR/

    • Related Report
      2013 Annual Research Report
  • [Remarks] EPR線量測定研究成果

    • URL

      http://trustrad.sixcore.jp/invivo_EPR/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://trustrad.sixcore.jp/invivo_EPR/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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