The role of miRNA on the mechanism of metastasis induced by the SDF-1/CXCR4 system in oral cancer
| Project/Area Number |
23592964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
UCHIDA Daisuke 徳島大学, ヘルスバイオサイエンス研究部, 助教 (20335798)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Youji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (20200214)
TAMATANI Tetsuya 徳島大学, 大学病院, 講師 (30274236)
OHE Go 徳島大学, 大学病院, 助教 (60432762)
KURIBAYASHI Nobuyuki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (80617332)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | CXCR4 / miR-518c-5p / 口腔癌 / miRNA / 転移 |
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| Research Abstract |
We examined the microRNA downstream of CXCR4 system that is one of a metastatic system in oral cancer. We identified the upregulation of miR-518c-5p, which is reported as an oncomiR in bladder cancer. A miR-518c-5p inhibitor significantly inhibited the CXCR4 system-dependent migration of oral cancer cells. The growth and migration of B88-518c cells, transfected by the miR-518c expression vector, were significantly enhanced. Furthermore, tumor volume, lymph nodes metastasis, and lung metastasis were significantly increased in the nude mice inoculated with B88-518c cells. These results indicated that miR-518c-5p regulates the metastases of oral cancer as a downstream target of CXCR4 system.
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Report
(4 results)
Research Products
(9 results)
