| Project/Area Number |
23593066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Fukuoka Dental College (2014)
Nagasaki University (2011-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARA Yoshitaka 長崎大学, 大学院医歯薬学総合研究科, 教授 (60159100)
YOSHIMURA Atsutoshi 長崎大学, 大学院石薬学総合研究科, 准教授 (70253680)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周病原細菌 / インフラマソーム / NLRP3 / カスパーゼ１ / NALP3 / カスパーゼ-1 / 歯周病源細菌 / IL-1β / NLRP1 / NLRC4 / ペプチドグリカン / IL-18 |
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| Outline of Final Research Achievements |
TInterleukin (IL)-1 is an inflammatory cytokine associated with periodontal break down and alveolar bone resorption, therefore the regulation of IL-1is important to inhibit onset/progression of periodontal disease. IL-1 secretion induced with periodontal pathogens (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum) is inhibited by the pretreatment with both Ac-YVAD-CMK and glyburide, indicating that IL-1 activation is dependent on both caspase-1 and NLRP3. These results indicate that the possibility of novel periodontal treatment that is targeted for caspase-1 and NLRP3.
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