The effect of IL-22 on biological activity of periodontal ligament cells
| Project/Area Number |
23593076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
OHYAMA hideki 兵庫医科大学, 医学部, 准教授 (90280685)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Nobuyuki 兵庫医科大学, 医学部, 名誉教授 (50150339)
NAKASHO Keiji 兵庫医科大学, 医学部, 教授 (00217712)
YAMADA Naoko 兵庫医科大学, 医学部, 講師 (10319858)
YAMANEGI Koji 兵庫医科大学, 医学部, 講師 (00434944)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯根膜細胞 / IL-22 / 石灰化誘導 / 歯根膜由来細胞 / ＩＬ－２２ / ヒト歯根膜由来細胞 |
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| Research Abstract |
This study focused on the biological effects of IL-22 on periodontal ligament (PDL) cells as part of studies to assess the involvement of IL-22 in periodontal disease. We found that IL-22 treatment had no effect on the proliferative response in PDL cells. Meanwhile, IL-22 precipitated mineralized nodule formation and induced gene expressions of RUNX2, MSX2 and osteocalcin in PDL cells, suggesting that IL-22 enhances the mineralized matrix-forming activities of PDL cells. In addition, the production of several cytokines including IL-11, IL-8 and CCL2 was upregulated by IL-22 treatment of PDL cells in a dose-dependent manner.IL-22 has the potential to promote mineralizing activity in PDL cells and to develop appropriate regenerative therapy.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Decreased expression of VE-cadherin and claudin-5 and increased phosphorylation of VE-cadherin in vascular endothelium in nasal polyps.2013
Author(s)
Yukitatsu Y, Hata M, Yamanegi K, Yamada N, Ohyama H, Nakasho K, Kojima Y, Oka H, Tsuzuki K, Sakagami M, Terada N.
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Journal Title
Cell Tissue Res
Volume: 352
Issue: 3
Pages: 647-657
DOI
Related Report
Peer Reviewed
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[Journal Article] The promotional effect of IL-22 on mineralization activity of periodontal ligament cells2012
Author(s)
Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H
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Journal Title
Cytokine
Volume: 59(1)
Issue: 1
Pages: 41-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma2012
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, YamadaN, Hata M, Fukunaga S, Futani H, Okamura H, Terada N.
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Journal Title
cells to Fas- and NK cell-mediated cell death.Int J Oncol.
Volume: 41(1)
Pages: 83-91
DOI
Related Report
Peer Reviewed
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[Journal Article] Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.2012
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N.
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Journal Title
Oncol Rep.
Volume: 28(5)
Issue: 5
Pages: 1585-1590
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation : Potential link with metabolic complications2011
Author(s)
Nakarai, H, Yamashita, A, Nagayasu, S, Iwashita, M, Kumamoto, S, Ohyama, H, Hata, M, Soga, Y, Kushiyama, A, Asano, T, Abiko, Y, Nishimura, F
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Journal Title
Innate Immunity
Volume: 18
Issue: 1
Pages: 164-170
DOI
Related Report
Peer Reviewed
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