• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Involvement of the metabolism pathway of S-Adenosyl methionine in epileptics

Research Project

Project/Area Number 23616007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field epigenetics
Research InstitutionNational Institute of Agrobiological Sciences

Principal Investigator

YOSHIKAWA Manabu  独立行政法人農業生物資源研究所, 植物・微生物間相互作用研究ユニット, 主任研究員 (80391564)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsエピジェネティク制御 / S-アデノシルメチオニン / メチオニン代謝
Research Abstract

In epigenetics, cytosines, histones and siRNAs are methylated. S-Adenosyl methionine (SAM) is used as a donor of methyl grope to them. However, it is unknown whether SAM is related to epigenetics in plants. To address this point, I performed this study using Arabidopsis mutants that are defective in SAM metabolisms. I explore transposons that are up-regulated in SAM metabolism defective mutants. I found that a few transposons are up-regulated in the mutants among some transposons. Next I analyzed the status of DNA methylation of up-regulated transposons. These results showed that DNA methylation at a locus is affected in SAM metabolism defective mutants and some epigenetic mutants. This observation implies that SAM metabolism is related to epigenetic regulation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Locus-specific requirements of DDR complexes for gene-body methylation of TAS genes in Arabidopsis thaliana2013

    • Author(s)
      Kanno T, Yoshikawa M, Habu Y
    • Journal Title

      Plant Molecular Biology Reporter

      Volume: 31 Pages: 1048-1052

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Biogenesis of trans-acting siRNAs: endogenous secondary siRNAs in plants2013

    • Author(s)
      Yoshikawa M
    • Journal Title

      Genes & Genetic Systems

      Volume: 88 Pages: 77-84

    • NAID

      10031183173

    • Related Report
      2013 Final Research Report
  • [Journal Article] Biogenesis of <i>trans</i>-acting siRNAs, endogenous secondary siRNAs in plants2013

    • Author(s)
      Yoshikawa M
    • Journal Title

      Genes & Genetic Systems

      Volume: 88 Issue: 2 Pages: 77-84

    • DOI

      10.1266/ggs.88.77

    • NAID

      10031183173

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 土生芳樹植物におけるRNAサイレンシング機構転写後型ジーンサイレンシング(PTGS)と転写型ジーンサイレンシング(TGS)2011

    • Author(s)
      吉川学, 菅野達夫
    • Journal Title

      細胞工学

      Volume: 30 Pages: 706-711

    • Related Report
      2013 Final Research Report
  • [Journal Article] 植物におけるRNAサイレンシング機構 転写後型ジーンサイレンシング(PTGS)と転写型ジーンサイレンシング(TGS)2011

    • Author(s)
      吉川 学, 菅野 達夫, 土生 芳樹
    • Journal Title

      細胞工学

      Volume: 30 Pages: 706-711

    • Related Report
      2011 Research-status Report
  • [Presentation] シロイヌナズナにおけるRNA scilencingを介した遺伝子発現抑制機構の解析2013

    • Author(s)
      菅野達夫, 吉川学, 土生芳樹
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      (3PW11-4 [ID :10373])
    • Related Report
      2013 Final Research Report
  • [Presentation] シロイヌナズナTAS遺伝子領域に見られるDNAのメチル化に関与するタンパク因子の解析2012

    • Author(s)
      菅野達夫, 不動寺晶子, 保坂アエニ, 吉川学, 土生芳樹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      (2P-153 [ID :9248])
    • Related Report
      2013 Final Research Report
  • [Presentation] シロイヌナズナTAS遺伝子領域に見られるDNAのメチル化に関与するタンパク因子の解析2012

    • Author(s)
      菅野達夫, 不動寺晶子, 保坂アエニ, 吉川学, 土生芳樹
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi