| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Human studies have shown a direct relationship between obesity and infertility in men and women. In the present study, we examined the mechanism of infertility by high fat diet-induced obesity in male mice. In addition, we examined whether L-carnitine can improve male infertility with diet-induced obesity. High fat diet-obesity resulted in decreased sperm motility and reduction in pregnancies of female partners. L-carntine supplementation itself did not seem to improve obesity-associated male infertility in male mice. Gene expression analysis of cauda epididymides suggested that DNA damage is increased in the sperm cells during spermatogenesis and/or sperm maturation in diet-induced obesity male mice and decreased expression of piRNA might be involved in the increased DNA damage in sperm.
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