The transport of polyunsaturated fatty acids across the placenta to the fetus and the subsequent growth and development of the infant
| Project/Area Number |
23617025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Kagawa Nutrition University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Kunihiko 東北大学, 大学院医学系研究科, 教授 (00291336)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | n-3系多価不飽和脂肪酸 / 母児間移行 / n-6系多価不飽和脂肪酸 / 臍帯血 / 母体血 / ω3多価不飽和脂肪酸 / 妊産婦栄養 / 出生コホート / 神経行動学的発達 |
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| Research Abstract |
We analyzed the polyunsaturated fatty acid (PUFA) compositions in maternal and cord blood erythrocytes of 523 pregnant women living along the shore of the Miyagi prefecture and determined the transport of arachidonic acid (ARA) and docosahexaenoic acid (DHA) across the placenta to the fetus. The PUFA levels of infants reflected those of their mothers, indicating that PUFA transport across the placenta to the fetus determined the PUFA compositions in cord blood erythrocytes. In the third trimester, the ARA level in maternal erythrocytes decreased compared with that in the second trimester, but no change in maternal DHA was observed. This finding suggested that the DHA in maternal blood satisfied the increasing demand of the fetus in the third trimester.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women.2011
Author(s)
Kawabata T, Hirota S, Hirayama T, Adachi N, Hagiwara C, Iwama N, Kamachi K, Araki E, Kawashima H, Kiso Y.
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Journal Title
Prostaglandins Leukot Essent Fatty Acids.
Volume: 84
Pages: 131-137
Related Report
Peer Reviewed
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