The elucidation of the impaired glucose tolerance mechanism to occur frequently in a thin youth woman

• Project/Area Number: 23617031
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Nagoya University of Arts and Sciences
• Principal Investigator: TSUKAHARA Takayoshi 名古屋学芸大学, 管理栄養学部, 教授 (00387911)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病 / インクレチン / インスリン分泌 / 食習慣 / 耐糖能異常 / やせ型 / インクレチン分泌

Research Abstract

We investigated the situation of impaired glucose tolerance (IGT) in young Japanese women and examined whether adoption of optimal carbohydrate intake could lead to improved IGT. We conducted a 75-g oral glucose tolerance test with 412 women enrolled at N University in Aichi Japan. IGT was found in 30.3% of the participants despite their young age. An open intervention study was conducted for 3 months with 26 of the women found to have IGT. The intervention was optimal carbohydrate intake based on body height 3 times per day.
After the intervention, Glucagon-like peptide-1 level at 30 min and insulinogenic index was significantly increased, and plasma glucose level at 30 and 60 min and HbA1c were significantly decreased. These data suggest that the adoption of optimal carbohydrate intake could lead to increased insulin secretion and improve IGT in young women.