Development of contrast agents that image tumor-specific protease for Overhauser effect-enhaced MRI
| Project/Area Number |
23650266
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University (2012-2013)
Kyushu University (2011) |
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Principal Investigator |
NIIDOME Takuro 熊本大学, 自然科学研究科, 教授 (20264210)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 医用・生体画像 / バイオイメージング / MRI / オーバーハウザー効果 / 腫瘍 / プロテアーゼ / オーバーハウザー効果MRI / 電子スピン共鳴 / デンドリマー / ニトロキシラジカル / ペプチド / オーバーハウザー効果ＭＲＩ / ＥＳＲ |
|---|
| Research Abstract |
Overhauser-enhanced MRI (OMRI) is a double resonance technique that uses the presence of paramagnetic agents such as nitroxyl radicals to enhance the signal intensity from nuclear spins by a process known as the Overhauser effect. In this study, dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the OMRI signal from the radicals. This system could be the basis of a functional tumor imaging technique by OMRI.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Cancer-specific gene carriers responding to cancer microenvironment : acidosis and hyper-activated protein kinases2013
Author(s)
S. Kushio, A. Tsuchiya, Y. Nakamura, T. Nobori, C. W. Kim, G. X. Zhao, T. Funamoto, E. K. Lee, T. Niidome, T. Mori, Y. Katayama
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Journal Title
Biomed. Eng-App. Bas. C
Volume: 25
Pages: 1340005-1340005
Related Report
Peer Reviewed
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[Journal Article] Stabilization of cancer-specific gene carrier via hydrophobic interaction for a clear-cut response to cancer signaling2013
Author(s)
C. W. Kim, R. Toita, J.-H. Kang, K.Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Nobori, Y. Nakamura, T. Mori, T. Niidome, Y. Katayama
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Journal Title
J. Controlled Release
Volume: 170
Pages: 469-476
Related Report
Peer Reviewed
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[Journal Article] Branched polyethylenimine-based PKCα-responsive gene carriers2013
Author(s)
Y. Nakamura, C. W. Kim, A. Tsuchiya, S. Kushio, T. Nobori, K. Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Niidome, T. Mori, Y. Katayama
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Journal Title
J. Biomater. Sci.-Polym. Ed
Volume: 24
Pages: 1858-1868
Related Report
Peer Reviewed
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[Journal Article] ancer-specific gene carriers responding to cancer microenvironment: acidosis and hyper-activated protein kinases2013
Author(s)
S. Kushio, A. Tsuchiya, Y. Nakamura, T. Nobori, C. W. Kim, G. X. Zhao, T. Funamoto, E. K. Lee, T. Niidome, T. Mori, Y. Katayama
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Journal Title
Biomed. Eng-App. Bas. C.
Volume: 25
Pages: 1340005-1340005
Related Report
Peer Reviewed
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[Journal Article] Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier2012
Author(s)
H. Arima, A. Yoshimatsu, H. Ikeda, A. Ohyama, K. Motoyama, T. Higashi, A. Tsuchiya, T. Niidome, Y. Katayama, K. Hattori, T. Takeuchi
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Journal Title
Mol. Pharmaceutics
Volume: 9
Issue: 9
Pages: 2591-2604
DOI
Related Report
Peer Reviewed
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[Journal Article] Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application2011
Author(s)
Yamashita, S., Fukushima, H., Akiyama, Y., Niidome, Y., Mori, T., Katayama, Y., Niidome, T.
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Journal Title
Bioorganic and Medicinal Chemistry
Volume: 19
Issue: 7
Pages: 2130-2135
DOI
Related Report
Peer Reviewed
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[Journal Article] A solid-in-oil dispersion of gold nanorods can enhance transdermal protein delivery and skin vaccination2011
Author(s)
Pissuwan, D., Nose, K., Kurihara, R., Kaneko, K., Tahara, Y., Kamiya, N., Goto, M., Katayama, Y., Niidome, T.
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Journal Title
Small
Volume: 7
Issue: 2
Pages: 215-220
DOI
Related Report
Peer Reviewed
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