Understanding of molecular mechanisms regulating leukemia stem cell behavior by multi-omics analysis
Project/Area Number |
23650593
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Kanazawa University |
Principal Investigator |
HIRAO Atsushi 金沢大学, がん進展制御研究所, 教授 (90343350)
|
Project Period (FY) |
2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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Keywords | 白血病幹細胞 / mTOR |
Research Abstract |
mTOR is an evolutionarily conserved kinase in eukaryotes that plays a critical role in sensing and responding to factors such as nutrient availability, energy sufficiency, stress, hormones, and mitogens. Since it was reported that mTOR complex 1(mTORC1) dysregulation promotes leukemogenesis and depletes hematopoietic stem cells, we attempted to understand the pathological roles of mTORC1 in leukemia behavior by multi-omics technology. In this study, we found that there are particular cell population showing obvious resistance to mTORC1 inactivation, and found several candidate molecules that are involved in the regulation of leukemia stem cells.
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Report
(2 results)
Research Products
(19 results)
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[Journal Article] Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer2011
Author(s)
El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.
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Journal Title
PLoS Genet
Volume: 7
Issue: 5
Pages: e1001385-e1001385
DOI
Related Report
Peer Reviewed
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[Journal Article] Invasion precedestumor mass formation in a malignant braintumor model of genetically modified neural stem cells2011
Author(s)
Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka S, Akahata M, Kai K, Sugimoto H, Hirao A, Saya H
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Journal Title
Neoplasia
Volume: 13(9)
Issue: 9
Pages: 784-91
DOI
Related Report
Peer Reviewed
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[Journal Article] Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells2011
Author(s)
Motohara T, Masuko S, Ishimoto T, Yae T, Onishi N, Muraguchi T, Hirao A, Matsuzaki Y, Tashiro H, Katabuchi H, Saya H, Nagano O.
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Journal Title
Carcinogenesis
Volume: 32
Issue: 11
Pages: 1597-606
DOI
Related Report
Peer Reviewed
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