Establishment of protocol for building up monoclonal antibodies targeting cancer stem cells
| Project/Area Number |
23650608
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAOAKA Ken 岡山理科大学, 理学部, 准教授 (10293317)
MURATA Hitoshi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90579096)
HUH Namho 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | がん幹細胞 / 抗体 / 膜タンパク質 / 腫瘍免疫 |
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| Research Abstract |
In this study, we succeeded to establish a cancer stem cell (CSC) clone by the innovative plasmid construct. Now, we are in the process of immunization of functional membrane proteins derived from the established CSC clone to generate a panel of monoclonal antibodies against CSCs.
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011
Author(s)
Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H
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Journal Title
Biochem Biophys Res Commun
Volume: 412
Pages: 391-395
Related Report
Peer Reviewed
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[Journal Article] TIRAP, an Adaptor Protein for TLR2/4, Transduces a signal from RAGE Phosphorylated upon Ligand Binding2011
Author(s)
Sakaguchi M, Murata M, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma2011
Author(s)
Kubo T, Toyooka S, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Ueno T, Muraoka T, Yamamoto H, Nasu Y, Kishimoto T, Pass HI, Matsui H, Huh NH, Miyoshi S
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Journal Title
Clin Cancer Res
Volume: 17
Pages: 4965-4974
Related Report
Peer Reviewed
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[Journal Article] Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma2011
Author(s)
Than SS, Kataoka K, Sakaguchi M, Murata H, Abarzua F, Taketa C, Du G, Yashiro M, Yanagihara K, Nasu Y, Kumon H, Huh NH
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Journal Title
Oncol Rep
Volume: 25
Pages: 989-995
Related Report
Peer Reviewed
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