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Photodynamic diagnosis of malignant brain tumor: analysis of molecular mechanisms and application to clinical diagnosis

Research Project

Project/Area Number 23650619
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor diagnosis
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ISHIKAWA Toshihisa  独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (60193281)

Co-Investigator(Kenkyū-buntansha) KUROIWA Toshihiko  大阪医科大学, 医学部, 教授 (30178115)
Co-Investigator(Renkei-kenkyūsha) OGURA Shun-ichiro  東京工業大学, フロンティア研究機構, 特任准教授 (90343160)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords悪性脳腫瘍 / 光線力学診断 / 光線力学治療 / 5-アミノレブリン酸(ALA) / ポルフィリン / ABCG2 / Nrf2 / 5-アミノレブリン酸( ALA) / 癌幹細胞 / 脳腫瘍 / トランスポーター / アミノレブリン酸 / メタボローム解析 / 遺伝子発現 / 代謝 / 光線力学診断法 / 転写制御 / バイオマーカー / 臨床応用
Research Abstract

Fluorescence-guided gross-total resection has recently been developed, where 5-aminolevulinic acid (ALA) is administered as the precursor of protoporphyrin IX (PpIX). This study has been undertaken to gain insight into the molecular mechanism underlying ALA-induced PpIX accumulation in malignant brain tumors. By comparing gene expression profiles, PpIX accumulation in brain tumor was found to be regulated by two transporters PEPT and ABCG2 that transport ALA and PpIX, respectively. Transcription factor Nrf2 plays a significant role in regulating ABCG2 gene expression, where one SNP (-617C>A) in the Nrf2 gene is suggested to be critically involved. We therefore developed a rapid and simple method to detect that SNP allele. Furthermore, we identified one drug that is potent for ABCG2-inhibition and may significantly enhance the efficacy of ALA-based photodynamic diagnosis and therapy.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (71 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (45 results) (of which Invited: 8 results) Book (7 results) Remarks (4 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 2 results)

  • [Journal Article] Inhibition of human ABC transporter ABCG2 by gefitinib to enhance the efficacy of ALA-photodynamic therapy of brain tumor: learning from in vitro and in vivo experiments.2014

    • Author(s)
      Inoue Y, Ikegami Y, Kajimoto Y, Kuroiwa T, Ishikawa T.
    • Journal Title

      ALA-Porphyrin Science

      Volume: 1 Pages: 27-35

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gefitinib enhances the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells.2013

    • Author(s)
      Sun Wei
    • Journal Title

      Photodiagnosis Photodyn Ther

      Volume: 10 Issue: 1 Pages: 42-50

    • DOI

      10.1016/j.pdpdt.2012.06.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of Nrf2 in cancer photodynamic therapy: regulation of human ABC transporter ABCG22013

    • Author(s)
      Ishikawa Toshihisa, Kajimoto Yoshinaga, Sun Wei, Nakagawa Hiroshi, Inoue Yoji, Ikegami Yutaka, Miyatake Shin-Ichi, Kuroiwa Toshihiko
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 102 Issue: 9 Pages: 3058-3069

    • DOI

      10.1002/jps.23563

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical SNP detection by SmartAmp method.2013

    • Author(s)
      Ishikawa T, Hayashizaki Y.
    • Journal Title

      Methods in Molecular Biology

      Volume: 1015 Pages: 55-69

    • DOI

      10.1007/978-1-62703-435-7_3

    • ISBN
      9781627034340, 9781627034357
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gefitinb Enhances the Antitumor Activity of CPT-11 in vitro and in vivo by Inhibiting ABCG2 but not ABCB12013

    • Author(s)
      Inoue Y, Ikegami Y, Sano K, Suzuki T, Yoshida H, Nakamura Y, Nakagawa H, Ishikawa T.
    • Journal Title

      Chemotherapy

      Volume: 59 Issue: 4 Pages: 260-271

    • DOI

      10.1159/000357772

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of human ABC transporter ABCG2 by gefitinib to enhanc e the efficacy of ALA-photodynamic thera py of brain tumor : learning from in vitro and in vivo experiments2013

    • Author(s)
      Inoue Y, Ikegami Y, Kajimoto Y, Kuroiwa T, Ishikawa T
    • Journal Title

      ALA-Porphyrin Science

      Volume: vol.1 Pages: 27-35

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro2012

    • Author(s)
      Hagiya Y, Endo Y, Yonemura Y, Takahashi K, Ishizuka M, Abe F, Tanaka T, Okura I, Nakajima M, Ishikawa T, Ogura S
    • Journal Title

      Photodiagnosis Photodyn Ther

      Volume: 9(3) Issue: 3 Pages: 204-214

    • DOI

      10.1016/j.pdpdt.2011.12.004

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transporter-mediated drug interaction strategy for ALA-based photodynamic diagnosis of malignant brain tumor : Molecular design of ABCG2 inhibitors2011

    • Author(s)
      Ishikawa T, Takahashi K, Ikeda N, Kajimoto Y, Hagiya Y, Ogura S, Miyatake S, Kuroiwa T
    • Journal Title

      Pharmaceutics

      Volume: vol.2 Pages: 615-635

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: the mechanism underlying 5-ALA-induced fluorescence in photodynamic diagnosis2011

    • Author(s)
      Takahashi K, Ikeda N, Nonoguchi N, Kajimoto Y, Miyatake S, Hagiya Y, Ogura S, Nakagawa H, Ishikawa T, Kuroiwa T.
    • Journal Title

      Neuro-Oncology

      Volume: 13 Pages: 1234-1243

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transporter-mediated drug interaction strategy for ALA-based photodynamic diagnosis of malignant brain tumor: Molecular design of ABCG2 inhibitors.2011

    • Author(s)
      Ishikawa T, Takahashi K, Ikeda N, Kajimoto Y, Hagiya Y, Ogura S, Miyatake S, Kuroiwa T.
    • Journal Title

      Pharmaceutics

      Volume: 3 Pages: 615-635

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 5-Aminolevulinic Acid (ALA)-Based Photodynamic Therapy of Malignant Brain Tumors and Glioma Stem Cells : From Basic Research to Clinical Applications of an ABCG2 Inhibitor2014

    • Author(s)
      Ishikawa T, Fujishiro T, Kajimoto Y, Inoue Y, Ikegami Y, Kuroiwa T
    • Organizer
      FEBS ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      オーストリア Innsbruck
    • Year and Date
      2014-03-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性脳腫瘍のALA 光線力学診断・治療に向けて : In silico 創薬分子デザインから臨床応用へ2014

    • Author(s)
      石川智久
    • Organizer
      第347回CBI 学会研究講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-02-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性脳腫瘍の光線力学診断と治療をめざしたABCG2阻害剤のデザイン2013

    • Author(s)
      井上裕貴, 池上洋二, 佐野和美, 黒岩敏彦, 石川智久
    • Organizer
      日本薬物動態学会2013年総会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 癌の光線力学治療におけるNrf2 の役割 : ABCG2 遺伝子発現の制御2013

    • Author(s)
      石川智久, 井上裕貴, 池上洋二, 中川大, 黒岩敏彦
    • Organizer
      日本薬物動態学会2013年総会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性脳腫瘍の光線力学診断と治療をめざしたABCG2阻害剤のデザイン2013

    • Author(s)
      井上裕貴, 池上洋二, 佐野和美, 黒岩敏彦, 石川智久
    • Organizer
      日本癌学会2013年総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2013-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of Nrf2 in photodynamic therapy : Regulation of ABCG2 gene expression2013

    • Author(s)
      Ishikawa T, Kajimoto Y, Inoue Y, Ikegami Y, Nakagawa Y, Kuroiwa T
    • Organizer
      日本生化学会2013年次大会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2013-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] New challenges in human ABC transporters research : From bench to clinical practice (Keynote lecture)2013

    • Author(s)
      Ishikawa T
    • Organizer
      International Conference on Role of MDR proteins in pharmacokinetics and toxicology
    • Place of Presentation
      ポーランド, Ryn, Zamek Ryn Hotel
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacogenomics of Drug Transporters and Clinical Applications2013

    • Author(s)
      Ishikawa T
    • Organizer
      The 2nd International Conference on Translational & Personalized Medicine
    • Place of Presentation
      米国シカゴHoliday Inn Chicago-North Shore
    • Year and Date
      2013-08-07
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 癌の多剤耐性トランスポーターのファーマコゲノミクス : 基礎研究から個別化医療に向けた新たな挑戦2013

    • Author(s)
      石川智久
    • Organizer
      愛媛大学医学部セミナー
    • Place of Presentation
      愛媛大学医学部
    • Year and Date
      2013-07-26
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Point-of-Care Technology for Personalized Medicine2013

    • Author(s)
      Ishikawa T
    • Organizer
      Bio-IT World & Molecular Med TRI-CON ASIA
    • Place of Presentation
      シンガポール
    • Year and Date
      2013-05-30
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 悪性脳腫瘍の光線力学診断と治療をめざしたABCG2 阻害剤のデザイン2013

    • Author(s)
      井上裕貴, 池上洋二, 佐野和美, 小金井美穂, 吉田久博, 藤城高広, 木村誠吾, 深見竹広, 梶本宜永, 宮武伸一, 黒岩敏彦, 石川智久
    • Organizer
      ポルフィリンALA 学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳腫瘍幹細胞様細胞に対する5-ALA PDT 感受性の評価2013

    • Author(s)
      藤城高広, 梶本宜永, 木村誠吾, 宮武伸一, 石川智久, 黒岩敏彦
    • Organizer
      ポルフィリンALA 学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 癌の光線力学治療におけるNrf2の役割 : ABCG2遺伝子の発現調節2013

    • Author(s)
      石川智久, 梶本宜永, Wei Sun , 井上裕貴, 池上洋二, 萩谷祐一郎, 小倉俊一郎, 宮武伸一, 黒岩敏彦
    • Organizer
      ポルフィリンALA学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Transporter-mediated drug interaction strategy for ALA-based photodynamic diagnosis of malignant brain tumor : molecular design of ABCG2 inhibitors2012

    • Author(s)
      Takahashi, K., Ikeda, N., Kajimoto, Y., Hagiya, Y., Ogura, S., Miyatake, S., Kuroiwa, T., Ishikawa, T
    • Organizer
      International Forum "Patients and Medicines"
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 5-Aminolevulinic Acid (ALA)-based photodynamic diagnosis of malignant brain tumor : Molecular design of ABCG2 inhibitors2012

    • Author(s)
      Ishikawa T., Kuroiwa T
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacogenomics of Human ABC Transporters : From Bench to Bedside2012

    • Author(s)
      Ishikawa T
    • Organizer
      Personalized Medicine in Cancer Treatment
    • Place of Presentation
      中国 Shenzhen
    • Year and Date
      2012-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] ポルフィリンを輸送するヒトABC トランスポーターABCG2 の遺伝子多型 : 迅速SNP 検出法の開発2012

    • Author(s)
      櫻井亜季, Alexander Lezhava, 林崎良英, 石川智久
    • Organizer
      第2回ポルフィリンALA 学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Transporter-mediated drug interaction strategy for ALA-based photodynamic diagnosis of malignant brain tumor : Molecular design of ABCG2 inhibitors2012

    • Author(s)
      Ishikawa T, Takahashi K, Ikeda N, Kajimoto Y, Hagiya Y, Ogura S, Saito H, Miyatake S-I, Kuroiwa T
    • Organizer
      薬物動態国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-01-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Transporter-mediated drug interaction strategy for ALA-based photodynamic diagnosis of malignant brain tumor: molecular design of ABCG2 inhibitors2012

    • Author(s)
      Takahashi, K., Ikeda, N., Kajimoto, Y., Hagiya, Y., Ogura, S., Miyatake, S., Kuroiwa, T., Ishikawa, T.
    • Organizer
      International Forum “Patients and Medicines"
    • Place of Presentation
      理化学研究所(横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] Transporter-mediated drug interaction strategy for ALA-based photodynamic diagnosis of malignant brain tumor: Molecular design of ABCG2 inhibitors2012

    • Author(s)
      Toshihisa Ishikawa, Kenkichi Takahashi, Naokado Ikeda, Yoshinaga Kajimoto, Yuichiro Hagiya, Shun-ichiro Ogura, Hikaru Saito, Shin-ichi Miyatake, and Toshihiko Kuroiwa
    • Organizer
      International Symposium on PPF Molecular Pharmacokinetics
    • Place of Presentation
      一橋記念講堂(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Recent Advances in the Human ABC Transporters Research : From Bench to Bedside2011

    • Author(s)
      Ishikawa T
    • Organizer
      ABC Symposium 2011
    • Place of Presentation
      京都
    • Year and Date
      2011-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] The Pivotal Role of PEPT1 and ABCG2 on 5-Aminolevulinic Acid (ALA)-based Photodynamic Sensitization of Cancer Cells in Vitro2011

    • Author(s)
      Hagiya Y, Endo Y, Yonemura Y, Takahashi K, Ishizuka M, Abe F, Nakajima M, Ishikawa T, Ogura S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular fluorescence imaging to assist neurosurgery of malignant brain tumors in humans : from bench to bedside2011

    • Author(s)
      Ishikawa, T., Takahashi, K., Ikeda, N., Kajimoto, Y., Hagiya, Y., Ogura, S., Miyatake, S., Kuroiwa, T
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Screening of transporters involved in porphyrin accumulation after administration of 5-aminolevulinic acid in vitro2011

    • Author(s)
      Matsumoto K, Hagiya Y, Nakagawa H, Ishikawa T, Ogura S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Recent Advances in the Human ABC Transporters Research: From Bench to Bedside2011

    • Author(s)
      Ishikawa T
    • Organizer
      ABC 2011 in Kyoto (招待講演)
    • Place of Presentation
      京都大学(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Molecular fluorescence imaging to assist neurosurgery of malignant brain tumors in humans: from bench to bedside2011

    • Author(s)
      Ishikawa, T., Takahashi, K., Ikeda, N., Kajimoto, Y., Hagiya, Y., Ogura, S., Miyatake, S., Kuroiwa, T.
    • Organizer
      13th Japanese-German Cancer Workshop(招待講演)
    • Place of Presentation
      グランドプリンスホテル広島(広島)
    • Related Report
      2011 Research-status Report
  • [Presentation] The Pivotal Role of PEPT1 and ABCG2 on 5-Aminolevulinic Acid (ALA)-based Photodynamic Sensitization of Cancer Cells in Vitro2011

    • Author(s)
      Yuichiro Hagiya, Yoshio Endo, Yutaka Yonemura, Kiwamu Takahashi, Masahiro Ishizuka, Fuminori Abe, Motowo Nakajima, Toshihisa Ishikawa, Shun-ichiro Ogura
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] Screening of transporters involved in porphyrin accumulation after administration of 5-aminolevulinic acid in vitro2011

    • Author(s)
      Kentaro Matsumoto, Yuichiro Hagiya, Hiroshi Nakagawa, Toshihisa Ishikawa, Shun-ichiro Ogura
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 癌の光線力学治療におけるNrf2の役割:ABCG2遺伝子の発現調節

    • Author(s)
      石川智久、梶本宜永、Wei Sun 、井上裕貴、池上洋二、萩谷祐一郎、小倉俊一郎、宮武伸一、黒岩敏彦
    • Organizer
      ポルフィリンALA学会
    • Place of Presentation
      東京工業大学すずかけ台キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性脳腫瘍の光線力学診断と治療をめざしたABCG2阻害剤のデザイン

    • Author(s)
      井上裕貴、池上洋二、佐野和美、小金井美穂、吉田久博、藤城高広、木村誠吾、深見竹広、梶本宜永、宮武伸一、黒岩敏彦、石川智久
    • Organizer
      ポルフィリンALA学会
    • Place of Presentation
      東京工業大学すずかけ台キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳腫瘍幹細胞様細胞に対する5-ALA PDT感受性の評価

    • Author(s)
      藤城高広、梶本宜永、木村誠吾、宮武伸一、石川智久、黒岩敏彦
    • Organizer
      ポルフィリンALA学会
    • Place of Presentation
      東京工業大学すずかけ台キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Point-of-Care Technology for Personalized Medicine

    • Author(s)
      Ishikawa T
    • Organizer
      Bio-IT World & Molecular Med TRI-CON ASIA
    • Place of Presentation
      Marina Bay Sands, Singapore, Singapore
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 癌の多剤耐性トランスポーターのファーマコゲノミクス:基礎研究から個別化医療に向けた新たな挑戦

    • Author(s)
      石川智久
    • Organizer
      愛媛大学医学部セミナー
    • Place of Presentation
      愛媛大学医学部
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pharmacogenomics of Drug Transporters and Clinical Applications

    • Author(s)
      Ishikawa T
    • Organizer
      The 2nd International Conference on Translational & Personalized Medicine
    • Place of Presentation
      Holiday Inn Chicago-North Shore, Chicago, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New challenges in human ABC transporters research: From bench to clinical practice

    • Author(s)
      Ishikawa T
    • Organizer
      International Conference on Role of MDR proteins in pharmacokinetics and toxicology
    • Place of Presentation
      Hotel Zamek Ryn, Ryn, Poland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The role of Nrf2 in photodynamic therapy: Regulation of ABCG2 gene expression

    • Author(s)
      Ishikawa T, Kajimoto Y, Inoue Y, Ikegami Y, Nakagawa Y, Kuroiwa Y
    • Organizer
      日本生化学会 2013年次大会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌の光線力学治療におけるNrf2の役割:ABCG2遺伝子発現の制御

    • Author(s)
      石川智久、井上裕貴、池上洋二、中川大、黒岩敏彦
    • Organizer
      日本癌学会2013年総会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性脳腫瘍の光線力学診断と治療をめざしたABCG2阻害剤のデザイン

    • Author(s)
      井上裕貴、池上洋二、佐野和美、黒岩敏彦、石川智久
    • Organizer
      日本癌学会2013年総会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌の光線力学治療におけるNrf2の役割:ABCG2遺伝子発現の制御

    • Author(s)
      石川智久、井上裕貴、池上洋二、中川大、黒岩敏彦
    • Organizer
      日本薬物動態学会2013年総会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性脳腫瘍の光線力学診断と治療をめざしたABCG2阻害剤のデザイン

    • Author(s)
      井上裕貴、池上洋二、佐野和美、黒岩敏彦、石川智久
    • Organizer
      日本薬物動態学会2013年総会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性脳腫瘍のALA光線力学診断・治療に向けて: In silico創薬分子デザインから臨床応用へ

    • Author(s)
      石川智久
    • Organizer
      第347回CBI学会研究講演会
    • Place of Presentation
      東京大学本郷キャンパス・山上会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5-Aminolevulinic Acid (ALA)-Based Photodynamic Therapy of Malignant Brain Tumors and Glioma Stem Cells: From Basic Research to Clinical Applications of an ABCG2 Inhibitor

    • Author(s)
      Ishikawa T, Fujishiro T, Kajimoto Y, Inoue Y, Ikegami Y, Kuroiwa T.
    • Organizer
      FEBS ATP-Binding Cassette (ABC) Proteins
    • Place of Presentation
      Hotel Grauer Baer, Innsbruck, Austria
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポルフィリンを輸送するヒトABCトランスポーターABCG2の遺伝子多型:迅速SNP検出法の開発

    • Author(s)
      櫻井亜季、Alexander Lezhava、林崎良英、石川智久
    • Organizer
      第2回ポルフィリンALA学会
    • Place of Presentation
      東京工業大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Pharmacogenomics of Human ABC Transporters: From Bench to Bedside

    • Author(s)
      Toshihisa Ishikawa
    • Organizer
      Personalized Medicine in Cancer Treatment
    • Place of Presentation
      中国Shenzhen
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 5-Aminolevulinic Acid (ALA)-based photodynamic diagnosis of malignant brain tumor: Molecular design of ABCG2 inhibitors

    • Author(s)
      Ishikawa T., Kuroiwa T.
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2012 Research-status Report
  • [Book] Pharmacogenomics of Human Drug Transporters : Clinical Impacts2013

    • Author(s)
      Ishikawa T, Konig J, Kim R. (本の編集)
    • Total Pages
      480
    • Publisher
      John-Willey & Sons, Hoboken, NJ, USA
    • Related Report
      2013 Final Research Report
  • [Book] Human ABC Transporter ABCC11. Ishikawa T, Konig J, Kim R. (eds.), Pharmacogenomics of Human Drug Transporters : Clinical Impacts2013

    • Author(s)
      Ishikawa T, Toyoda Y
    • Publisher
      John-Willey & Sons
    • Related Report
      2013 Final Research Report
  • [Book] Emerging new technology of SNP typing. Ishikawa T, Konig J, Kim R. (eds.), Pharmacogenomics of Human Drug Transporters : Clinical Impacts2013

    • Author(s)
      Ishikawa T, Hayashizaki Y
    • Publisher
      John-Willey & Sons
    • Related Report
      2013 Final Research Report
  • [Book] Future perspectives. Ishikawa T, Konig J, Kim R. (eds.), Pharmacogenomics of Human Drug Transporters : Clinical Impacts2013

    • Author(s)
      Ishikawa T, Ware J
    • Publisher
      John-Willey & Sons
    • Related Report
      2013 Final Research Report
  • [Book] Pharmacogenomics of Human Drug Transporters: Clinical Impacts2013

    • Author(s)
      Ishikawa T, Kim RB, Koenig J.
    • Total Pages
      422
    • Publisher
      Wiley, Hoboken, NJ, USA
    • Related Report
      2013 Annual Research Report
  • [Book] Pharmacogenomics of Human Drug Transporters: Clinical Impacts2013

    • Author(s)
      Ishikawa T, Kim R., Konig J, (編集)
    • Total Pages
      433
    • Publisher
      John-Welley & Sons, Hoboken, NJ, USA
    • Related Report
      2012 Research-status Report
  • [Book] Recent advances in pharmacogenomic technology for personalized medicine. In : Drug Metabolism2011

    • Author(s)
      Ishikawa T, Hayashizaki Y
    • Publisher
      InTech Open Access Publisher
    • Related Report
      2013 Final Research Report
  • [Remarks] 理化学研究所サイエンスアゴラ : 悪性脳腫瘍ALA 光線治療に関するムービー石川智久, 黒岩敏彦, 深見竹広(ホームページ等)

    • URL

      http://www.youtube.com/watch?v=IwO99s_0eUE

    • Related Report
      2013 Final Research Report
  • [Remarks] 文部科学省新学術領域研究「がん研究分野の特性等をふまえた支援活動」 ホームページ 石川智久(ホームページ等)

    • URL

      http://ganshien.umin.jp/public/research/spotlight/ishikawa/

    • Related Report
      2013 Final Research Report
  • [Remarks] 理化学研究所サイエンスアゴラ

    • URL

      http://www.youtube.com/watch?v=IwO99s_0eUE

    • Related Report
      2013 Annual Research Report
  • [Remarks] がん研究分野の特性等を踏まえた支援活動

    • URL

      http://ganshien.umin.jp/public/research/spotlight/ishikawa/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 治療抵抗性がんの予防又は治療用組成物2014

    • Inventor(s)
      石川智久, 黒岩敏彦, 梶本宜永, 藤城高広, 木村誠吾, 宮武伸一, 田中徹
    • Industrial Property Rights Holder
      理化学研究所, 大阪医科大学, SBIファーマ株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-031220
    • Filing Date
      2014-02-21
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 治療抵抗性がんの予防用又は治療用組成物2014

    • Inventor(s)
      石川智久、黒岩敏彦、梶本宜永 他
    • Industrial Property Rights Holder
      理化学研究所、大阪医科大学、SBIファーマ株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-031220
    • Filing Date
      2014-02-21
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 化合物の生理活性の定量的予測方法2012

    • Inventor(s)
      平野弘之, 辻川登, 石川智久
    • Industrial Property Rights Holder
      石川智久, 辻川登
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-08-31
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 化合物の生理活性の定量的予測方法2012

    • Inventor(s)
      平野弘之, 辻川登, 石川智久
    • Industrial Property Rights Holder
      石川智久, 辻川登(すべての指定国)平野弘之(米国のみ)
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-08-31
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Photodynamic treatment of brain tumor2012

    • Inventor(s)
      Toshihisa Ishikawa
    • Industrial Property Rights Holder
      Toshihisa Ishikawa
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-09-11
    • Related Report
      2012 Research-status Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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