Fabrication of a tailor-made and heat generating bio-nanoparticle for DDS
| Project/Area Number |
23651112
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
IWAHORI Kenji 奈良先端科学技術大学院大学, 物質創成科学研究科, 研究員 (90467689)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノ粒子・ナノチューブ / フェリチン / 発熱 / 磁性 / ハイパーサーミア / ナノ粒子 / 磁性ナノ粒子 / 温熱効果 / バイオテンプレート |
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| Research Abstract |
I succeeded to synthesize iron oxide nano-particles (NPs) in a bio-template,apoferritin by some detail investigation of reaction conditions. A diameter of the synthesized NP in the apoferritin is about 5-6 nm and it can bind to Neodymium magnets. It is clear that the synthesized NP consist of Fe3O4 by the XRD, EDX analysis and HR-TEM observation. This NP is expected to generate heat for a hyperthermia effect. In addition, I also succeeded to synthesized CuS, FeS, and Ta NPs in the apoferritin cavity. The diameter of CuS NPs in the apoferritin cavity is 5 nm and it consists of Cu2S by the XRD, EDX analysis. I perform an elemental analysis of the other cores and magnetic observation. Recently, I constructed a plasmid of another apoferritin protein from human heart and I synthesized iron oxide NPs in this apoferritin. Since this apoferritin included NP and is suitable for our DDS and various nanotechnology applications, I continue to elucidate the magnetic character and some improvement of these NPs in the apoferritin.
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Report
(3 results)
Research Products
(14 results)
