Reversible photoregulaton of microtubule dynamics and development of artificial bio-molecular machines
| Project/Area Number |
23655111
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional materials chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAMEI Takashi 北海道大学, 電子科学研究所, 助教 (90450650)
TAMAOKI Nobuyuki 北海道大学, 電子科学研究所, 教授 (00344218)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | フォトクロミズム / 微小管 / 重合阻害剤 / アゾベンゼン / 生体機能 / 分子マシン / モータータンパク |
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| Research Abstract |
In this study, we tried to synthesize novel azobenzene derivatives, which can reversibly regulate the microtubule depolymerization-polymerization dynamics with external light stimuli, and attempted to develop artificial bio-molecular machines. For such purpose, we prepared several azobenzene derivatives having different kinds of substituent with different positions and rigorously investigated the effect on the microtubule polymerization dynamics. From detailed investigations, it was revealed that the amphiphilic structure of azobenzene was essential to achieve the reversible photoregulation of microtubule polymerization dynamics.
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Report
(3 results)
Research Products
(36 results)
