Origin of the polarity during mouse development

• Project/Area Number: 23657148
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Osaka University
• Principal Investigator: TAKAOKA Katsuyoshi 大阪大学, 生命機能研究科, 助教 (90551044)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 極性 / 着床前胚 / 転写 / エピジェネティクス / インプリンティング / 卵割 / 受精

Research Abstract

It is thought that human and mouse embryos acquire the first polarity of body axes during early development. In this study, a new knowledge will be acquired during early mouse embryo development, and be showed the detail of the mechanism. As a results, I showedthat (1) Ac
(1) Activity of LFE were shown in some blastomeres of 4-16 cell stage embryos.
(2) LFE positive cells contributed to extra-embryonic tissues.

Research Products

• [Journal Article] Fluid Flow and Interlinked Feedback Loops Establish Left-Right Asymmetric Decay of Cerl2 mRNA in the Mouse Embryo (2012)
  • Author(s): *Tetsuya Nakamura, Daisuke Saito, Aiko Kawasumi, Kyosuke Shinohara, Yasuko Asai, Katsuyoshi Takaoka, Henglan Dong, Atsuko Takamatsu, Jese Antonio Belo, *Atsushi Mochizuki and Hiroshi Hamada
  • Journal Title: Nature communications Volume: 1322
  • Peer Reviewed
• [Journal Article] Cell fate decisions and axis determination in the early mouse embryo (2012)
  • Author(s): *Katsuyoshi Takaoka, *Hiroshi Hamada
  • Journal Title: Development Volume: 3
  • Peer Reviewed
• [Journal Article] Cell specification and axis formation in the mouse embryo (2012)
  • Author(s): Katsuyoshi Takaoka
  • Journal Title: Development Volume: 139 Issue: 1 Pages: 3-14
  • DOI: 10.1242/dev.060095
  • Peer Reviewed
• [Journal Article] Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA in the mouse embryo (2012)
  • Author(s): Nakamura, T., Saito, D., Kawasumi, A., Shinohara, K., Asai, Y., Takaoka, K., Dong, F., Takamatsu, A., Belo, J.A., Mochizuki, A., and Hamada, H.
  • Journal Title: Nat.Communic Volume: 3 Issue: 1 Pages: 1322-1322
  • DOI: 10.1038/ncomms2319
  • Peer Reviewed
• [Journal Article] Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo (2011)
  • Author(s): *Katsuyoshi Takaoka, Masamichi Yamamoto and *Hiroshi Hamada
  • Journal Title: Nature Cell Biology Volume: vol.13(7) Pages: 743-52
  • Peer Reviewed
• [Journal Article] Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo (2011)
  • Author(s): Katsuyoshi Takaoka
  • Journal Title: Nat. Cell Biol. Volume: 13 Issue: 7 Pages: 743-752
  • DOI: 10.1038/ncb2251
  • Peer Reviewed
• [Presentation] マウス胚における前後軸の起源 (2013)
  • Author(s): 高岡勝吉
  • Organizer: CRESTシンポジウム
  • Place of Presentation: 秋葉原
  • Year and Date: 2013-02-25
• [Presentation] マウス胚における前後軸の起源 (2012)
  • Author(s): 高岡勝吉
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 博多
  • Year and Date: 2012-12-11
• [Presentation] Origin of Anterior-posterior axis formation in the mouse embryos (2012)
  • Author(s): Katsuyoshi Takaoka
  • Organizer: Hong Kong Society for Developmental Biology Symposium
  • Place of Presentation: 香港
  • Year and Date: 2012-11-26
• [Presentation] マウス胚における前後軸の起源 (2012)
  • Author(s): 高岡勝吉
  • Organizer: 新学術領域研究 細胞コミュニティー
  • Place of Presentation: 葉山、神奈川県
  • Year and Date: 2012-11-19
• [Presentation] Origin of Anterior-posterior axis formation in the mouse embryos (2012)
  • Author(s): Katsuyoshi Takaoka
  • Organizer: 第45回日本発生学会・第64回日本細胞生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-05-28
• [Presentation] マウス胚における前後軸の起源 (2011)
  • Author(s): 高岡勝吉
  • Organizer: 新学術領域研究 細胞コミュニティー
  • Place of Presentation: 愛知
  • Year and Date: 2011-11-25
• [Presentation] Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo (2011)
  • Author(s): Katsuyoshi Takaoka, Masamichi Yamamoto, Hiroshi Hamada
  • Organizer: 第44回発生生物学会
  • Place of Presentation: 沖縄
• [Presentation] 「マウス胚における前後軸の起源」 (2011)
  • Author(s): 高岡勝吉
  • Organizer: 新学術領域研究、細胞コミュニティー
  • Place of Presentation: あいち健康プラザ宿泊館
• [Presentation] 「Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo」 (2011)
  • Author(s): Katsuyoshi Takaoka
  • Organizer: 第４４回発生生物学会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] マウス胚における前後軸の起源
  • Author(s): 高岡勝吉
  • Organizer: 新学術領域研究、細胞コミュニティー
  • Place of Presentation: 神奈川県三浦郡葉山町
• [Presentation] Origin of Anterior-posterior axis formation in the mouse embryos
  • Author(s): Katsuyoshi Takaoka
  • Organizer: Hong Kong Society for Developmental Biology Symposium
  • Place of Presentation: 香港,中国
• [Presentation] 「マウス胚における前後軸の起源」
  • Author(s): 高岡勝吉
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 博多
• [Presentation] 「マウス胚における前後軸の起源」
  • Author(s): 高岡勝吉
  • Organizer: CRESTシンポジウム
  • Place of Presentation: 秋葉原
• [Book] ライフサイエンス新着論文レビュー First author's (2011)
  • Author(s): 高岡勝吉、濱田博司
  • Publisher: マウス胚の前後方向を決定する遠位臓側内胚葉の起源と役割
• [Book] マウス胚の前後方向を決定する遠位臓側内胚葉の起源と役割 (2011)
  • Author(s): *高岡勝吉、濱田博司
  • Total Pages: 1
  • Publisher: ライフサイエンス新着論文レビュー First author’s (ウェブ総説)