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Extinction of constitutive heterochromatin blocks in humans: structural analysis for clarification of mechanisms

Research Project

Project/Area Number 23657165
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical anthropology
Research InstitutionKyoto University

Principal Investigator

KOGA Akihiko  京都大学, 霊長類研究所, 教授 (80192574)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords染色体 / 反復配列 / ヘテロクロマチン / セントロメア / テロメア / ヒト科 / テナガザル科
Research Abstract

This study deals with rapid changes in the amount of constitutive heterochromatin, including emergence, amplification, reduction and extinction. These changes are frequently observed in many primate groups, such as hominids and gibbons. Cloning, sequencing and hybridization experiments revealed that such rapid changes are associated with integration of repetitive sequencesinto the centromere or telomere and the speed of change depends on their nucleotide sequences.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Heterochromatin blocks constituting the entire short arms of acrocentric chromosomes of Azara's owl monkey: formation processes inferred from chromosomal locations(ヨザルのアクロセントリック染色体短腕を構成するヘテロクロマチン:染色体上の配置から推測される形成過程)2013

    • Author(s)
      Prakhongcheep O, Chaiprasertsri N, Terada S, Hirai Y, Srikulnath K, Hirai H, *Koga A
    • Journal Title

      DNA Research

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ hybridization analysis of gibbon chromosomes suggests that amplification of alpha satellite DNA in the telomere region is confined to two of the four genera2012

    • Author(s)
      Baicharoen S, Arsaithamkul V, Hirai Y, Hara T, Koga A, Hirai H
    • Journal Title

      Genome

      Volume: 55 Issue: 11 Pages: 809-812

    • DOI

      10.1139/gen-2012-0123

    • NAID

      120005054806

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] repeat sequences evolutionarily related to SVA-type retrotransposons are expanded in the centromere region of the western hoolock gibbon, a small ape2012

    • Author(s)
      Hara T, Hirai Y, Jahan I, Hirai H, Koga A
    • Journal Title

      Journal of Human Genetics

      Volume: 57 Issue: 12 Pages: 760-765

    • DOI

      10.1038/jhg.2012.107

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Under-representation of repetitive sequences in whole-genome shotgun sequence databases: an illustration using a recently acquired transposable element.2012

    • Author(s)
      Koga A
    • Journal Title

      Genome

      Volume: 55 Issue: 2 Pages: 172-175

    • DOI

      10.1139/g11-088

    • NAID

      120003988291

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repetitive sequences originating from the centromere constitute large-scale heterochromatin in the telomere region in the siamang, a small ape2012

    • Author(s)
      Koga A, Hirai Y, Hara T, Hirai H
    • Journal Title

      Heredity

      Volume: 109 Issue: 3 Pages: 180-187

    • DOI

      10.1038/hdy.2012.28

    • NAID

      120005243749

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repetitive sequences originating from the centromere constitute large-scale heterochromatin in the telomere region in the siamang, a small ape2012

    • Author(s)
      Koga A, Hirai Y, Hara T, Hirai H
    • Journal Title

      Heredity

      Volume: 印刷中

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] テナガザルにみられるトランスポゾンのゲノムへの影響:セントロメアへのヘテロクロマチンの供給2012

    • Author(s)
      古賀章彦・原暢・イスラト ジャハン・平井百合子・平井啓久
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      椙山女学園大学(名古屋市)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] テナガザルの染色体端部にある大規模ヘテロクロマチンの主成分2012

    • Author(s)
      平井啓久・原暢・平井百合子・古賀章彦
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      椙山女学園大学(名古屋市)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] テナガザルにみられるトランスポゾンのゲノムへの影響:セントロメアへのヘテロクロマチンの供給2012

    • Author(s)
      古賀章彦・原暢・イスラト ジャハン・平井百合子・平井啓久
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      椙山女学園大学(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] テナガザルの染色体端部にある大規模ヘテロクロマチンの主成分2012

    • Author(s)
      平井啓久・原暢・平井百合子・古賀章彦
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      椙山女学園大学(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] チンパンジーにあってヒトにない染色体端部ゲノム不毛地帯:(2) 培養細胞を用いた組換えの検出2011

    • Author(s)
      古賀章彦・平井百合子・平井啓久
    • Organizer
      第27回日本霊長類学会大会
    • Place of Presentation
      犬山国際観光センター(愛知県犬山市)
    • Year and Date
      2011-07-18
    • Related Report
      2012 Final Research Report
  • [Presentation] チンパンジーにあってヒトにない染色体端部ゲノム不毛地帯:(1) 存在様式変異から推測される非相同染色体間末端組換え2011

    • Author(s)
      平井啓久・平井百合子・古賀章彦・鵜殿俊史
    • Organizer
      第27回日本霊長類学会大会
    • Place of Presentation
      犬山国際観光センター(愛知県犬山市)
    • Year and Date
      2011-07-18
    • Related Report
      2012 Final Research Report
  • [Presentation] チンパンジーにあってヒトにない染色体端部ゲノム不毛地帯:(1) 存在様式変異から推測される非相同染色体間末端組換え

    • Author(s)
      平井啓久・平井百合子・古賀章彦・鵜殿俊史
    • Organizer
      第27回日本霊長類学会大会
    • Place of Presentation
      犬山国際観光センター
    • Related Report
      2011 Research-status Report
  • [Presentation] チンパンジーにあってヒトにない染色体端部ゲノム不毛地帯:(2) 培養細胞を用いた組換えの検出

    • Author(s)
      古賀章彦・平井百合子・平井啓久
    • Organizer
      第27回日本霊長類学会大会
    • Place of Presentation
      犬山国際観光センター
    • Related Report
      2011 Research-status Report
  • [Remarks] 京都大学霊長類研究所

    • URL

      http://www.pri.kyoto-u.ac.jp/index-j.html

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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