| Project/Area Number |
23658088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATAOKA Hiroshi 東京大学, 新領域創成科学研究科, 教授 (60202008)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂肪細胞 / 膜タンパク質 / GHITM / ミトコンドリア / ペルオキシソーム / Ghitm / ノックアウトマウス / 脂質代謝 |
|---|
| Research Abstract |
To elucidate the regulation of energy metabolism by PGDR/GHITM, which is conserved from mammalian to insect, we analyzed 1) Cellular localization of PGDR/GHITM, 2) Lipid content and composition of tissues in the presence or absence of PGDR/GHITM, 3) The adipocyte differentiation and regulation of gene expression through PGDR/GHITM.
As a result, 1) GDR/GHITM is localization in mitochondria compare to peroxisome, 2) PGDR/GHITM may mediate to maintain mitochondrial morphology, 3) Fatty acid composition is different between wild-type and Ghitm knockout mouse.
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