| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
It is known that P450 which is a useful biological catalyst can carry out the monooxigenation of the medicine and chemicals.Especially P450 can carry out metabolic activation of various chemical substances which participate in the generation of cancer cells. We know that the chemical substance with has mutagenicity can increase the cancer cells in our body. In general, these mutagenic chemicals are metabolic activated by P450 monooxygenase. On the other hand, there is a little information about the mechanism for the activation of non-mutagenic chemicals. In this research, we show that the isothiocyanate which is a non-mutagenicity substance of food origin can regulate the total amount of mRNA of P450.
|
