| Project/Area Number |
23659049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHUTO Satoshi 北海道大学, 大学院・薬学研究院, 教授 (70241346)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAWAKI Ken 北海道大学, 大学院・薬学研究院, 特任助教 (60451407)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 医薬分子設計 / cADPR / β細胞 / ラジカル反応 / Huisegen反応 / 光反応 |
|---|
| Research Abstract |
As the key molecule to develop effective biological tools for theidentification of target proteins of cADPR in cells, 4” α-aziceethyl-cADPcR (3) was designedand successfully synthesized. 4” α-Azidoethyl-cADPcR (3) was shown to be biologically activeas we expected.
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