• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of methodology forchemical synthesis of proteins based on kinetically controlled peptide bond formation

Research Project

Project/Area Number 23659055
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research InstitutionThe University of Tokushima

Principal Investigator

OTAKA Akira  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20201973)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsペプチド / チオエステル / 速度論的支配 / Native Chemical Ligation / タンパク質合成 / アシル転移 / 速度論的反応 / NCL / 速度論支配 / ペプチド合成
Research Abstract

N-Sulfanylethylanilide (SEAlide) peptides were developed with the aim of achieving facile synthesis of peptide thioesters. The SEAlide moiety was proved to function as a thioester in the presence of phosphate salts and to participate in native chemical ligation (NCL) with N-terminal cysteinyl peptides, and this has served as a powerful protein synthesis methodology. The reactivity of a SEAlide peptide (anilide vs thioester) can be easily tuned with or without the use of phosphate salts. This interesting property of SEAlide peptides allows sequential three-fragment or unprecedented four-fragment ligation for efficient one-pot peptide/protein synthesis. Chemical synthesis of 162-residue GM2AP was achieved using the kinetically controlled ligation based on the SEAlide chemistry.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (80 results)

All 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (54 results) (of which Invited: 5 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Chemical synthesis of biologically active monoglycosylated GM2-activator protein analog using N-sulfanylethylanilide peptide2013

    • Author(s)
      K. Sato, A. Shigenaga, K. Kitakaze, K. Sakamoto, D. Tsuji, K. Itoh, A. Otaka
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: vol.52 Issue: 30 Pages: 7855-7859

    • DOI

      10.1002/anie.201303390

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis2013

    • Author(s)
      K. Tanegashima, K. Suzukia, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. tiara
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 12 Pages: 1731-1735

    • DOI

      10.1016/j.febslet.2013.04.046

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells2012

    • Author(s)
      Shigenaga, A., et al.
    • Journal Title

      ChemBioChem

      Volume: 13 Issue: 7 Pages: 968-971

    • DOI

      10.1002/cbic.201200141

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthetic Procedure for N-Fmoc Amino Acyl-N-Sulfanylethylaniline Linker as Crypto-Peptide Thioester Precursor with Application to Native Chemical Ligation2012

    • Author(s)
      Sakamoto K, et al.
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 77 Issue: 16 Pages: 6948-6958

    • DOI

      10.1021/jo3011107

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide2012

    • Author(s)
      Otaka A
    • Journal Title

      Chemical Record

      Volume: 12 Issue: 5 Pages: 479-490

    • DOI

      10.1002/tcr.201200007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fmoc-based solid phase synthesis of adenylylated peptides using diester-type adenylylated amino acid derivatives2012

    • Author(s)
      Ogura, K.; Shigenaga, A.; Ebisuno, K.; Hirakawa, H.; Otaka, A
    • Journal Title

      Tetrahedron Lett

      Volume: (in press) Issue: 27 Pages: 3429-3432

    • DOI

      10.1016/j.tetlet.2012.04.063

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Organic and Bio-organic Methodologies for the Synthesis of Proteins2012

    • Author(s)
      大高 章
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 70 Issue: 10 Pages: 1054-1068

    • DOI

      10.5059/yukigoseikyokaishi.70.1054

    • NAID

      10031124010

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer2012

    • Author(s)
      Shigenaga, A.
    • Journal Title

      Peptide Science 2011

      Volume: - Pages: 385-386

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Doubly-kinetically controlled proline ligation2012

    • Author(s)
      Ding, H.
    • Journal Title

      Peptide Science 2011

      Volume: - Pages: 133-134

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation2012

    • Author(s)
      Sato, K.
    • Journal Title

      Peptide Science 2011

      Volume: - Pages: 13-14

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2011

    • Author(s)
      Yamamoto, J.; Tanaka, T.; Denda, M.; Shigenaga, A.; Nomura, W.; Tamamura, H.; Otaka, A
    • Journal Title

      Biopolymers

      Volume: 96 Pages: 492-492

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
    • Journal Title

      Biopolymers

      Volume: 96 Pages: 447-447

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of N-C-or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation2011

    • Author(s)
      Tsuji, K.; Shigenaga, A.; Sumikawa, Y.; Tanegashima, K.; Sato, K.; Aihara, K.; Hara, T.; Otaka, A
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Issue: 13 Pages: 4014-4020

    • DOI

      10.1016/j.bmc.2011.05.018

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer2011

    • Author(s)
      Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Tsuji, D.; Itoh, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 3984-3990

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-sulfanylethylanilide derivative as a peptide thioester equivalent2011

    • Author(s)
      Sato, K.; Tsuda, S.; Tsuji, K.; Sakamoto, K.; Shigenaga, A.; Otaka, A
    • Journal Title

      Biopolymers

      Volume: 96 Pages: 445-445

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Sulfanylethylanilide peptide as a crypto-thioester peptide2011

    • Author(s)
      Sato, K.; Shigenaga, A.; Tsuji, K.; Tsuda, S.; Sumikawa, Y.; Sakamoto, K.; Otaka, A
    • Journal Title

      ChemBioChem

      Volume: 12 Issue: 12 Pages: 1840-1844

    • DOI

      10.1002/cbic.201100241

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dual kinetically-controlled native chemical ligation using a combi-nation of sulfanylproline and sulfanyl-ethylanilide peptide2011

    • Author(s)
      Ding, H.; Shigenaga, A.; Sato, K.; Morishita, K.; Otaka, A
    • Journal Title

      Org. Lett

      Volume: 13 Issue: 20 Pages: 5588-5591

    • DOI

      10.1021/ol202316v

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of UV-responsive catch-and-release system of a cysteine protease model peptide2011

    • Author(s)
      Shigenaga, A.; Morishita, K.; Yamaguchi, K.; Ding, H.; Ebisuno, K.; Sato, K.; Yamamoto, J.; Akaji, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 46 Pages: 8879-8886

    • DOI

      10.1016/j.tet.2011.09.062

    • NAID

      120006493356

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation2011

    • Author(s)
      Sato, K.
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Volume: - Pages: 72-73

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      Tsuji, K.
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Volume: - Pages: 74-75

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 標的タンパク質の精製・選択的ラベル化ツール『トレーサブルリンカー』の開発2013

    • Author(s)
      山本 純
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 過酸化水素応答型アミノ酸の開発研究2013

    • Author(s)
      北 未来
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid.2012

    • Author(s)
      Otaka, A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      北海道
    • Year and Date
      2012-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム 2012 年【春】
    • Place of Presentation
      慶應義塾大学、東京都
    • Year and Date
      2012-06-06
    • Related Report
      2012 Final Research Report
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka, A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル大学, Seoul, Korea
    • Year and Date
      2012-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル国立大学薬学部 (Seoul, Korea)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム2012年【春】
    • Place of Presentation
      慶應義塾大学薬学部マルチメディア講堂(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製法の開発2012

    • Author(s)
      山本 純
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学国際交流ホール(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究2012

    • Author(s)
      傳田 将也
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都大学国際交流ホール(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] タンパク質完全化学合成-ケミストによるタンパク質医薬品開発を目指して-2012

    • Author(s)
      佐藤 浩平
    • Organizer
      第44回若手ペプチド夏の勉強会
    • Place of Presentation
      ロッジ舞洲(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 4-チオプロリンを用いたDual-kinetic NCL法の開発2012

    • Author(s)
      丁 昊
    • Organizer
      第44回若手ペプチド夏の勉強会
    • Place of Presentation
      ロッジ舞洲(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      アステラス製薬シンポジウム
    • Place of Presentation
      アステラスつくば研究センター(茨城県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] "化学"でペプチド・タンパク質をあやつる2012

    • Author(s)
      重永 章
    • Organizer
      第28回若手化学者のための化学道場
    • Place of Presentation
      島根県青少年の家 (島根県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012

    • Author(s)
      Otaka A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Development of novel antagonistic peptide for CXCL14 receptor2012

    • Author(s)
      Tsuji K
    • Organizer
      The 6th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      武田薬品研究所 (大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemical synthesis of human GM2 activator protein analog using SEAlide peptide-mediated one-pot multi-fragment condensation2012

    • Author(s)
      Sato K
    • Organizer
      The 6th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      武田薬品研究所 (大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012

    • Author(s)
      Otaka A
    • Organizer
      The Sixth Peptide Engineering Meeting
    • Place of Presentation
      Emory大学コンファレンスセンター (Atlanta, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of antagonistic peptide for putative CXCL14 receptor proteins and their identification2012

    • Author(s)
      Tsuji K
    • Organizer
      第49回ペプチド討論会
    • Place of Presentation
      かごしま県民交流センター (鹿児島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Convergent chemical synthesis of human GM2 activator protein analog using SEAlide chemistry2012

    • Author(s)
      Sato K
    • Organizer
      第49回ペプチド討論会
    • Place of Presentation
      かごしま県民交流センター (鹿児島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of efficient synthetic protocol for Fmoc amino acid-incorporated N-sulfanylethyl-aniline linker as peptide thioester precursor2012

    • Author(s)
      Sakamoto K
    • Organizer
      第49回ペプチド討論会
    • Place of Presentation
      かごしま県民交流センター (鹿児島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Design and synthesis of hypoxia-responsive amino acid which causes peptide bond cleavage in hypoxic cells2012

    • Author(s)
      Shigenaga A
    • Organizer
      第49回ペプチド討論会
    • Place of Presentation
      かごしま県民交流センター (鹿児島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 酸化ストレス応答型アミノ酸の開発研究2012

    • Author(s)
      北 未来
    • Organizer
      第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンラポーむらくも (島根県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] タンパク質選択的ラベル化法の開発研究2012

    • Author(s)
      傳田 将也
    • Organizer
      第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンラポーむらくも (島根県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ケージド非水解性リン酸化アミノ酸含有ペプチドの合成とタンパク質結合能の評価2012

    • Author(s)
      戎野 紘司
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      タワーホール船堀 (東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リソソーム病治療薬を指向したヒトGM2活性化タンパク質誘導体の化学合成と活性評価2012

    • Author(s)
      佐藤 浩平
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      タワーホール船堀 (東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] CXCL14受容体の同定とそのアンタゴニストペプチドの合成2012

    • Author(s)
      辻 耕平
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      タワーホール船堀 (東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製実験2012

    • Author(s)
      山本 純
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      タワーホール船堀 (東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] フッ化物イオン応答型アミノ酸の開発と標的タンパク質精製ツールへの応用2012

    • Author(s)
      山本 純
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 4-チオプロリンを用いたNative Chemical Ligation2012

    • Author(s)
      丁 昊
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] リン酸化タンパク質の機能解明に向けたケージド非水解性リン酸化アミノ酸含有ペプチドの合成研究2012

    • Author(s)
      傳田将也
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] CXCL14・CXCL12デュアルアンタゴニストペプチドの創製2012

    • Author(s)
      粟飯原圭佑
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規チオール応答型アミノ酸の合成とDNA放出システムへの展開2012

    • Author(s)
      戎野紘司
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] タンパク質化学合成を指向したN-アミノアシルN-置換アニリンリンカーの効率的合成法の開発2012

    • Author(s)
      坂本 健
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高 章、重永 章
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県立大学、兵庫県
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Native chemical ligation (NCL) without using peptide thioester2011

    • Author(s)
      佐藤浩平
    • Organizer
      14th Peptide Forum(招待講演)
    • Place of Presentation
      鹿児島大学(鹿児島市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Application of Stimulus-responsive Amino Acid to Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2011

    • Author(s)
      山本 純
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] The First Accomplishment of Development of CXCL14 Antagonistic Peptide by Dimerization of CXCL14 Fragment2011

    • Author(s)
      辻 耕平
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] AMP化タンパク質の機能解明を指向したペプチド性分子ツールの開発2011

    • Author(s)
      小倉圭司
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Related Report
      2011 Research-status Report
  • [Presentation] CXCL14およびその誘導体の効率的合成法の開発と活性評価2011

    • Author(s)
      辻 耕平
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Related Report
      2011 Research-status Report
  • [Presentation] リン酸化タンパク質の機能解明に向けた紫外線応答型リン酸化アミノ酸誘導体の合成研究2011

    • Author(s)
      傳田将也
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Related Report
      2011 Research-status Report
  • [Presentation] ペプチドチオエステル合成用アニリン型補助基への効率的アミノ酸導入法の開発2011

    • Author(s)
      坂本 健
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Related Report
      2011 Research-status Report
  • [Presentation] タンパク質AMP化の生理学的意義解明を指向した新規分子ツールの開発2011

    • Author(s)
      小倉圭司
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 4-メルカプトプロリンを用いたペプチドフラグメント縮合法の開発2011

    • Author(s)
      丁 昊
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島市)
    • Related Report
      2011 Research-status Report
  • [Presentation] タンパク質化学合成を指向したワンポット4成分連続縮合法の開発2011

    • Author(s)
      佐藤浩平
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高 章
    • Organizer
      日本生物物理学会第49回年会(招待講演)
    • Place of Presentation
      兵庫県立大学(姫路市)
    • Related Report
      2011 Research-status Report
  • [Presentation] N-Sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation2011

    • Author(s)
      佐藤浩平
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer2011

    • Author(s)
      重永 章
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Double-kinetically controlled proline ligation2011

    • Author(s)
      丁 昊
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] タンパク質AMP化の生理学的意義解明に向けたAMP化アミノ酸誘導体の創製2011

    • Author(s)
      小倉圭司
    • Organizer
      創薬懇話会2011
    • Place of Presentation
      ダイヤモンド瀬戸内マリンホテル(岡山市)
    • Related Report
      2011 Research-status Report
  • [Presentation] タンパク質化学合成を指向したワンポット4成分連続縮合法の開発2011

    • Author(s)
      佐藤浩平
    • Organizer
      創薬懇話会2011
    • Place of Presentation
      ダイヤモンド瀬戸内マリンホテル(岡山市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Design and synthesis of traceable linker for efficient enrichment and specific labeling of target proteins2011

    • Author(s)
      山本 純
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      Sheraton hotel (San Diego USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] N-sulfanylethylanilide derivative as a peptide thioester equivalent2011

    • Author(s)
      佐藤浩平
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      Sheraton hotel (San Diego USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      辻 耕平
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      Sheraton hotel (San Diego USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] AMP化タンパク質の機能解明に向けたAMP化アミノ酸誘導体の創製2011

    • Author(s)
      小倉圭司
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学(東京都)
    • Related Report
      2011 Research-status Report
  • [Book] 「第12 章 生理活性ペプチドホルモン」生体有機化学2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Related Report
      2012 Final Research Report
  • [Book] 刺激応答型アミノ酸の開発と生命科学分野への応用」遺伝子医学 MOOK 21 号 最新ペプチド合成技術とその創薬研究への応用2012

    • Author(s)
      重永 章、山本 純、大高 章
    • Publisher
      メディカルドゥ
    • Related Report
      2012 Final Research Report
  • [Book] 生体有機化学・12章 生理活性ペプチドホルモン2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Related Report
      2012 Annual Research Report
  • [Book] 遺伝子医学MOOK 21号 最新ペプチド合成技術とその創薬研究への応用・刺激応答型アミノ酸の開発と生命科学分野への応用2012

    • Author(s)
      重永 章
    • Publisher
      メディカルドゥ
    • Related Report
      2012 Annual Research Report
  • [Book] 遺伝子医学MOOK 21号 最新ペプチド合成技術とその創薬研究への応用「刺激応答型アミノ酸の開発と生命科学分野への応用」2012

    • Author(s)
      重永 章
    • Publisher
      メディカルドゥ
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.tokushima-u.ac.jp/ph/faculty/labo/otaka/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi