| Project/Area Number |
23659114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Chiaki 琉球大学, 大学院・医学研究科, 助教 (00443664)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | TRPM7 / チャネル / キナーゼ / コレステロール代謝 / コレステロール / NASH / 糖尿病 / 代謝疾患 |
|---|
| Research Abstract |
We have made the kinase dead knock-in mouse with replacement of the key residue for ATP binding in kinase domain to investigate a possible role of kinase activity f TRPM7. This mutant mouse grows normally, but show significant abnormality of cholesterol metabolism. In addition, we identified the cholesterol secretion from hepatocyte was severely defect in these mutant mouse.
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