| Project/Area Number |
23659120
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Naoko 東北大学, 医学(系)研究科(研究院), 助教 (40457750)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takashi 東北大学, 大学院医学系研究科, 教授 (10261629)
小澤 信義 独立行政法人国立病院機構(仙台医療センター臨床研究部), その他部局等, その他 (30169289)
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| Research Collaborator |
FUKUDO Shin 東北大学, 大学院医学系研究科, 教授 (80199249)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん / ストレス / CRH / QOL / CRHR1 / CRHR2 / 生存率 |
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| Outline of Final Research Achievements |
Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1
(CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma.In our study results, CRH, CRHR1, and CRHR2 immunoreactivitywas detected in the cytoplasm of endometrial carcinoma cells. And suggest that intratumoral CRH-CRHR1 signaling plays an important role in the progression of endometrial carcinoma and that CRHR1 is a potent prognostic factor in patients with this disease.
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