Molecular basis for regulation of the cellular life span
Project/Area Number |
23659155
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Hiroshi 群馬大学, 生体調節研究所, 准教授 (70334125)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 遺伝子 / シグナル伝達 / 生体分子 / マイクロアレイ / 老化 |
Research Abstract |
Cells constituting organs in the mammals have cell-type-specific life span after their terminal differentiation. The differences in cellular life span are though to be dependent on cell characteristics and functions. However, the molecular basis underlying the regulation of the life span of terminally differentiated cells is not fully elucidated. Moreover, the biological significance of cell-type-specific life span still remains unclear. To clarify the mechanism of the regulation of cellular life span, we performed approaches using mouse intestinal epithelial cells as a model.
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Report
(3 results)
Research Products
(59 results)
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[Journal Article] Dendritic cell-specific ablation of the protein tyrosine phosphatase shp1 promotes Th1 cell differentiation and induces autoimmunity.2012
Author(s)
Kaneko T., Saito Y., Kotani T., Okazawa H., Iwamura H., Sato-Hashimoto M., Kanazawa Y., Takahashi S., Hiromura K., Kusakari S.Kaneko Y., Murata Y., Ohnishi H., Nojima Y., Takagishi K., and Matozaki T.
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Journal Title
J. Immunol
Volume: 188
Issue: 11
Pages: 5397-5407
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain2012
Author(s)
Maruyama T., Kusakari S., Sato-Hashimoto M., Hayashi Y., Kotani T., Murata Y., Okazawa H., Oldenborg P.-A., Kishi S., Matozaki T., and Ohnishi H.
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Journal Title
J. Neurochem
Volume: 121
Issue: 6
Pages: 891-902
DOI
Related Report
Peer Reviewed
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[Journal Article] CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction2011
Author(s)
Zhao XW, van Beek EM, Schornagel K, Van der Maaden H, Van Houdt M, Otten MA, Finetti P, Van Egmond M, Matozaki T, Kraal G, Birnbaum D, van Elsas A, Kuijpers TW, Bertucci F, van den Berg TK
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Journal Title
Proc Natl Acad Sci USA
Volume: 108
Issue: 45
Pages: 18342-7
DOI
Related Report
Peer Reviewed
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[Journal Article] SIRPα /CD172a regulates eosinophil homeostasis2011
Author(s)
Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ, Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M
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Journal Title
J Immunol
Volume: 187
Issue: 5
Pages: 2268-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.2011
Author(s)
Sato-Hashimoto M., Saito Y., Ohnishi H., Iwamura H., Kanazawa Y., Kusakari S., Kotani T., Mori M., Murata Y., Okazawa H., Ware CF., Olodenbrg PA., Nojima Y., and Matozaki T.
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Journal Title
J. Immunol
Volume: 187
Issue: 1
Pages: 291-297
DOI
Related Report
Peer Reviewed
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