| Project/Area Number |
23659419
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Okayama University |
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Principal Investigator |
OH Hidemasa 岡山大学, 岡山大学病院, 教授 (50372579)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓内幹細胞 / 直接再プログラム化 / 心筋細胞 / 転写因子 / 直接リプログラミング / 人工心筋細胞 / ヘテロカリオン / 心筋分化 / 細胞融合 |
|---|
| Research Abstract |
We employed a heterokaryon-based gene screening approach to identify the crucial transcription factors might be involved in direct cardiac reprogramming. By using this novel technique, we found a series of transcription factors essential for right and left ventricular formation include GATA4, Mef2c, Tbx5, Myocardin, and Hand2 were capable of converting the cardiac progenitor cells toward mature cardiomyocytes directly in vitro.
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