Application of RAGE inhibitor inhalation for COPD
Project/Area Number |
23659430
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
WATANABE Takuo 金沢学院短期大学, 教授 (40303268)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 閉塞性肺疾患 / RAGE / cAMP / MMP9 / MMP / シェディング / A594 / BEAS-2B / 定量的RT-PCR |
Research Abstract |
(1) We found that ligand-dependent RAGE signal was suppressed by cAMP-dependent signaling pathway, using mouse macrophage culture system. (2) We showed that cAMP-dependent signal caused activation of MMP9 that accelerated shedding of membrane-bound form RAGE, which resulted in decrease of membrane-bound form RAGE and increase of soluble form RAGE. (3) The mechanism of the suppression of ligand-dependent RAGE signal by cAMP-dependent signal was supposed that the acceleration of shedding of membrane-bound form RAGE via cAMP-dependent signal resulted in decrease of membrane-bound form RAGE functioning signal transducer and increase of soluble form RAGE functioning decoy receptor.
|
Report
(3 results)
Research Products
(92 results)
-
-
-
-
-
[Journal Article] Receptor for advanced glycation end-products (RAGE) regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 22013
Author(s)
Monden M, Koyama H, Otsuka Y, Morioka T, Mori K, Shoji T, Mima Y, Motoyama K, Fukumoto S, Shioi A, Emoto M, Yamamoto H, Nishizawa Y, Kurajoh M, Tetsuya Yamamoto T, Inaba M
-
Journal Title
Diabetes
Volume: 62
Issue: 2
Pages: 478-489
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status2012
Author(s)
Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, Ota T
-
Journal Title
Diabetes IN PRESS
Volume: 61(7)
Issue: 7
Pages: 1680-90
DOI
Related Report
Peer Reviewed
-
[Journal Article] Endogenous Secretory Receptor for Advanced Glycation End-Products Inhibits Amyloid-beta1-42 Uptake into Mouse Brain2012
Author(s)
Sugihara T., Munesue S., Yamamoto Y., Sakurai S., Akhter N., Kitamura Y., Shiba K., Watanabe T., Yonekura H., Hayashi Y., Hamada J. I. and Yamamoto H.
-
Journal Title
J Alzheimers Dis
Volume: 28
Issue: 3
Pages: 709-720
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Anti-high mobility group box-1 antibody therapy for traumatic brain injury2012
Author(s)
Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, Yamamoto Y, Yamamoto H, Takahashi H K, Mori S, Nishibori M
-
Journal Title
Annals of Neurology
Volume: 72
Issue: 3
Pages: 373-384
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] RAGE binds phosphatidylserine and assists in the clearance of apoptotic cells2011
Author(s)
He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahashi T, Yamada M, Yamaya M, Maekawa T, Yamamoto Y, Yamamoto H.
-
Journal Title
EMBO Reports
Volume: 12
Issue: 4
Pages: 358-364
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-