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A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

Research Project

Project/Area Number 23659432
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionOkayama University

Principal Investigator

KIURA Katsuyuki  岡山大学, 岡山大学病院, 教授 (10243502)

Co-Investigator(Kenkyū-buntansha) TAKIGAWA Nagio  川崎医科大学, 医学部, 教授 (60325107)
ICHIHARA Eiki  岡山大学, 大学院・医歯薬学総合研究科, 講師 (40549705)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA Eizo  岡山大学, 地球物質科学研究センター, 教授 (80201672)
YOSHINO Tadashi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70183704)
TAKATA Minoru  京都大学, 放射線生物研究センター, 教授 (30281728)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords非閉塞性肺疾患癌 / 悪性中皮腫 / ラジウム / 生体内被曝 / 鉄 / 発癌 / プリミティブマントル正規化微量原素パターン / ラット / 含鉄蛋白 / 体内被曝 / (1)含鉄蛋白質
Research Abstract

Ten healthy male Slc: Wistar rats were repeatedly injected (i.p.) with a chelating agent and iron. Five of 10 rats showed a malignant peritoneal mesothelioma, but no rats showed it in the control and the chelating agent administration group. The tumor cells were positively stained by Calretinin and CEA. The results of immunostaining and the findings by electron microscope indicated epithelial mesothelioma. In addition, immunostaining with 8-hydroxy-2-deoxyguanosine is a DNA oxidative damage marker was positive. Thus, the conventional theoriy was confirmed. The final analysis of trace elements including radium is ongoing.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.2012

    • Author(s)
      Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T..
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 3 Pages: 510-4

    • DOI

      10.1111/j.1349-7006.2011.02180.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer2012

    • Author(s)
      Ueno T, Tsukuda K, Toyooka S, Ando M, Takaoka M, Soh J, Asano H, Maki Y, Muraoka T, Tanaka N, Shien K, Furukawa M, Yamatsuji T, Kiura K, Naomoto Y, Miyoshi S.
    • Journal Title

      Lung Cancer

      Volume: 76 Issue: 1 Pages: 26-31

    • DOI

      10.1016/j.lungcan.2011.09.011

    • NAID

      120005311966

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.2012

    • Author(s)
      Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T.
    • Journal Title

      Cancer Sci.

      Volume: 103 Pages: 510-514

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Is adenosine deaminase in pleural fluid a useful marker for differentiating tuberculosis from lung cancer or mesothelioma in Japan, a country with intermediate incidence of tuberculosis?2011

    • Author(s)
      Ogata Y, Aoe K, Hiraki A, Murakami K, Kishino D, Chikamori K, Maeda T, Ueoka H, Kiura K, Tanimoto M.
    • Journal Title

      Acta Med Okayama

      Volume: 65 Pages: 259-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Medical treatment of mesothelioma: anything new?2011

    • Author(s)
      Takigawa N, Kiura K, Kishimoto T
    • Journal Title

      Curr Oncol Rep

      Volume: 13 Issue: 4 Pages: 265-71

    • DOI

      10.1007/s11912-011-0172-1

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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