A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

• Project/Area Number: 23659432
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Okayama University
• Principal Investigator: KIURA Katsuyuki 岡山大学, 岡山大学病院, 教授 (10243502)
• Co-Investigator(Kenkyū-buntansha): TAKIGAWA Nagio 川崎医科大学, 医学部, 教授 (60325107) ; ICHIHARA Eiki 岡山大学, 大学院・医歯薬学総合研究科, 講師 (40549705)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Eizo 岡山大学, 地球物質科学研究センター, 教授 (80201672) ; YOSHINO Tadashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70183704) ; TAKATA Minoru 京都大学, 放射線生物研究センター, 教授 (30281728)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 非閉塞性肺疾患癌 / 悪性中皮腫 / ラジウム / 生体内被曝 / 鉄 / 発癌 / プリミティブマントル正規化微量原素パターン / ラット / 含鉄蛋白 / 体内被曝 / (1)含鉄蛋白質

Research Abstract

Ten healthy male Slc: Wistar rats were repeatedly injected (i.p.) with a chelating agent and iron. Five of 10 rats showed a malignant peritoneal mesothelioma, but no rats showed it in the control and the chelating agent administration group. The tumor cells were positively stained by Calretinin and CEA. The results of immunostaining and the findings by electron microscope indicated epithelial mesothelioma. In addition, immunostaining with 8-hydroxy-2-deoxyguanosine is a DNA oxidative damage marker was positive. Thus, the conventional theoriy was confirmed. The final analysis of trace elements including radium is ongoing.

Research Products

• [Journal Article] Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma. (2012)
  • Author(s): Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T..
  • Journal Title: Cancer Sci Volume: 103 Issue: 3 Pages: 510-4
  • DOI: 10.1111/j.1349-7006.2011.02180.x
  • Peer Reviewed
• [Journal Article] Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer (2012)
  • Author(s): Ueno T, Tsukuda K, Toyooka S, Ando M, Takaoka M, Soh J, Asano H, Maki Y, Muraoka T, Tanaka N, Shien K, Furukawa M, Yamatsuji T, Kiura K, Naomoto Y, Miyoshi S.
  • Journal Title: Lung Cancer Volume: 76 Issue: 1 Pages: 26-31
  • DOI: 10.1016/j.lungcan.2011.09.011
  • NAID: 120005311966
  • Peer Reviewed
• [Journal Article] Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma. (2012)
  • Author(s): Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T.
  • Journal Title: Cancer Sci. Volume: 103 Pages: 510-514
  • Peer Reviewed
• [Journal Article] Is adenosine deaminase in pleural fluid a useful marker for differentiating tuberculosis from lung cancer or mesothelioma in Japan, a country with intermediate incidence of tuberculosis? (2011)
  • Author(s): Ogata Y, Aoe K, Hiraki A, Murakami K, Kishino D, Chikamori K, Maeda T, Ueoka H, Kiura K, Tanimoto M.
  • Journal Title: Acta Med Okayama Volume: 65 Pages: 259-63
  • Peer Reviewed
• [Journal Article] Medical treatment of mesothelioma: anything new? (2011)
  • Author(s): Takigawa N, Kiura K, Kishimoto T
  • Journal Title: Curr Oncol Rep Volume: 13 Issue: 4 Pages: 265-71
  • DOI: 10.1007/s11912-011-0172-1
  • Peer Reviewed