The circadian clocks condition neuronal/endocrine/immune axis
Project/Area Number |
23659499
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | University of Yamanashi |
Principal Investigator |
NAKAO Atsuhito 山梨大学, 大学院・医学工学総合研究部, 教授 (80317445)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 体内時計 / 神経 / 内分泌 / 免疫 / マスト細胞 / アレルギー反応 / アレルギー・ぜんそく / 医療・福祉 |
Research Abstract |
This study showed that the time of day-dependent variation in the skin allergic reaction observed in the sham-operated mice was absent in the mice with the physical ablation of the SCN. In addition, the time of day-dependent variation in the skin allergic reaction was absent in the mice with specific deletion of the Clock gene in mast cells. These results suggest the circadian clocks drive the daily rhythms in the skin allergic reaction by mediating temporal regulation of the nervous/endocrine/immune systems.
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G2013
Author(s)
Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Severe dermatitis with loss of epidermal langerhans cells in human and mouse zinc deficiency2012
Author(s)
Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta T, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S
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Journal Title
J Clin Invest
Volume: 122(2)
Pages: 722-732
Related Report
Peer Reviewed
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[Journal Article] Dietary resveratrol prevents the development of food allergy in mice2012
Author(s)
Okada, Y., K. Oh-oka, Y. Nakamura, K. Ishimaru, S. Matsuoka, K. Okumura, H. Ogawa, M. Hisamoto, T. Okuda, and A. Nakao
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Journal Title
PLoS One
Volume: 7
Issue: 9
Pages: e44338-e44338
DOI
Related Report
Peer Reviewed
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